SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3blx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 3blx ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 2
(Saccharomyces
cerevisiae) 		4 / 8 ALA B  83
LEU B 133
SER B 267
THR B 265
 None
 0.95A 1dvtA-3blxB:
undetectable
1dvtB-3blxB:
undetectable		 1dvtA-3blxB:
17.85
1dvtB-3blxB:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 3blx ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 2
(Saccharomyces
cerevisiae) 		3 / 3 SER B 324
VAL B 303
LEU B 300
 None
 0.72A 1yajG-3blxB:
undetectable		 1yajG-3blxB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3blx ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 2
(Saccharomyces
cerevisiae) 		4 / 7 ILE B   8
GLY B   9
LEU B 109
PHE B 110
 None
 0.96A 2vctD-3blxB:
undetectable		 2vctD-3blxB:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 3blx ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 2
(Saccharomyces
cerevisiae) 		3 / 3 LEU B 298
GLU B  28
ILE B  27
 None
 0.53A 3czhA-3blxB:
undetectable		 3czhA-3blxB:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3blx ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 2
(Saccharomyces
cerevisiae) 		4 / 6 VAL B 113
ILE B 179
ILE B 134
LEU B 133
 None
 0.57A 3hegA-3blxB:
undetectable		 3hegA-3blxB:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 3blx ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 2
(Saccharomyces
cerevisiae) 		4 / 5 PHE B 110
ILE B 270
GLY B 108
HIS B 272
 None
 1.30A 3r0lD-3blxB:
undetectable		 3r0lD-3blxB:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2C_A_ACTA153_0
(N UTILIZATION
SUBSTANCE PROTEIN B)		 3blx ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 2
(Saccharomyces
cerevisiae) 		4 / 4 ASN B 244
GLY B 140
GLU B 141
LYS B 158
 None
 1.48A 3r2cA-3blxB:
1.5		 3r2cA-3blxB:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 3blx ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 2
(Saccharomyces
cerevisiae) 		3 / 3 HIS B 308
GLY B 271
ILE B 270
 None
 0.51A 4k50A-3blxB:
undetectable		 4k50A-3blxB:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 3blx ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 2
(Saccharomyces
cerevisiae) 		3 / 3 HIS B 308
GLY B 271
ILE B 270
 None
 0.49A 4k50I-3blxB:
undetectable		 4k50I-3blxB:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 3blx ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 2
(Saccharomyces
cerevisiae) 		5 / 12 SER B 302
VAL B 350
LEU B 354
ILE B  43
LEU B 306
 None
 1.11A 4y8wA-3blxB:
undetectable		 4y8wA-3blxB:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 3blx ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 2
(Saccharomyces
cerevisiae) 		5 / 12 SER B 302
VAL B 350
LEU B 354
ILE B  43
LEU B 306
 None
 1.12A 4y8wB-3blxB:
undetectable		 4y8wB-3blxB:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 3blx ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 2
(Saccharomyces
cerevisiae) 		5 / 12 ILE B  32
PRO B 295
SER B 302
GLY B  86
GLY B  33
 None
 1.01A 5l6eA-3blxB:
undetectable		 5l6eA-3blxB:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 3blx ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 2
(Saccharomyces
cerevisiae) 		3 / 3 SER B 258
SER B 255
ALA B 297
 None
 0.72A 6dwnC-3blxB:
undetectable		 6dwnC-3blxB:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 3blx ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 2
(Saccharomyces
cerevisiae) 		5 / 12 GLU B  54
LEU B  99
ALA B  73
SER B  76
LEU B 103
 None
 1.12A 6ew0B-3blxB:
undetectable		 6ew0B-3blxB:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 3blx ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 2
(Saccharomyces
cerevisiae) 		5 / 12 GLU B  54
LEU B  99
ALA B  73
SER B  76
LEU B 103
 None
 1.12A 6ew0D-3blxB:
undetectable		 6ew0D-3blxB:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 3blx ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 2
(Saccharomyces
cerevisiae) 		5 / 12 GLU B  54
LEU B  99
ALA B  73
SER B  76
LEU B 103
 None
 1.12A 6ew0F-3blxB:
undetectable		 6ew0F-3blxB:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 3blx ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 2
(Saccharomyces
cerevisiae) 		5 / 12 GLU B  54
LEU B  99
ALA B  73
SER B  76
LEU B 103
 None
 1.13A 6ew0G-3blxB:
undetectable		 6ew0G-3blxB:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 3blx ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 2
(Saccharomyces
cerevisiae) 		5 / 12 GLU B  54
LEU B  99
ALA B  73
SER B  76
LEU B 103
 None
 1.12A 6ew0H-3blxB:
undetectable		 6ew0H-3blxB:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 3blx ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 2
(Saccharomyces
cerevisiae) 		5 / 12 GLU B  54
LEU B  99
ALA B  73
SER B  76
LEU B 103
 None
 1.12A 6ew0I-3blxB:
undetectable		 6ew0I-3blxB:
13.64