SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bm3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 3bm3 PSPGI RESTRICTION
ENDONUCLEASE
(Pyrococcus
sp.
GI-H) 		5 / 12 LEU A 111
ILE A  66
LEU A  31
LEU A  37
LEU A  40
 None
 1.23A 1errB-3bm3A:
undetectable		 1errB-3bm3A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)		 3bm3 PSPGI RESTRICTION
ENDONUCLEASE
(Pyrococcus
sp.
GI-H) 		4 / 5 ILE A 249
ARG A 211
ARG A 244
ASP A 248
 None
 1.34A 2rhmB-3bm3A:
undetectable		 2rhmB-3bm3A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 3bm3 PSPGI RESTRICTION
ENDONUCLEASE
(Pyrococcus
sp.
GI-H) 		5 / 12 VAL A 159
GLY A 191
ILE A 215
PRO A  52
SER A 247
 None
 1.25A 3bjwF-3bm3A:
undetectable		 3bjwF-3bm3A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 3bm3 PSPGI RESTRICTION
ENDONUCLEASE
(Pyrococcus
sp.
GI-H) 		5 / 9 ILE A 253
LEU A 112
ILE A 140
PHE A 139
LYS A 160
 None
 1.34A 3sj4X-3bm3A:
undetectable		 3sj4X-3bm3A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3bm3 PSPGI RESTRICTION
ENDONUCLEASE
(Pyrococcus
sp.
GI-H) 		4 / 7 PHE A 104
VAL A 159
ILE A 157
GLU A  60
 None
 1.10A 4a97E-3bm3A:
4.4		 4a97E-3bm3A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3bm3 PSPGI RESTRICTION
ENDONUCLEASE
(Pyrococcus
sp.
GI-H) 		4 / 8 PHE A 104
VAL A 159
ILE A 157
GLU A  60
 None
 0.66A 4a97D-3bm3A:
4.4		 4a97D-3bm3A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3bm3 PSPGI RESTRICTION
ENDONUCLEASE
(Pyrococcus
sp.
GI-H) 		4 / 8 PHE A 104
VAL A 159
ILE A 157
GLU A  60
 None
 1.04A 4a97G-3bm3A:
undetectable		 4a97G-3bm3A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3bm3 PSPGI RESTRICTION
ENDONUCLEASE
(Pyrococcus
sp.
GI-H) 		4 / 7 PHE A 104
VAL A 159
ILE A 157
GLU A  60
 None
 0.83A 4a97H-3bm3A:
1.3		 4a97H-3bm3A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3bm3 PSPGI RESTRICTION
ENDONUCLEASE
(Pyrococcus
sp.
GI-H) 		4 / 8 PHE A 104
VAL A 159
ILE A 157
GLU A  60
 None
 0.89A 4a97I-3bm3A:
4.4		 4a97I-3bm3A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3bm3 PSPGI RESTRICTION
ENDONUCLEASE
(Pyrococcus
sp.
GI-H) 		5 / 11 SER A  53
VAL A 214
GLU A 194
SER A 247
ASP A 248
 None
 1.27A 4d9hA-3bm3A:
undetectable		 4d9hA-3bm3A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3bm3 PSPGI RESTRICTION
ENDONUCLEASE
(Pyrococcus
sp.
GI-H) 		4 / 6 LYS A 126
ILE A 127
LYS A 136
LEU A 177
 None
 1.11A 4em2A-3bm3A:
undetectable		 4em2A-3bm3A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3bm3 PSPGI RESTRICTION
ENDONUCLEASE
(Pyrococcus
sp.
GI-H) 		4 / 6 ILE A  55
PRO A  52
PHE A 246
PHE A 192
 None
 1.23A 4fgkA-3bm3A:
undetectable		 4fgkA-3bm3A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3bm3 PSPGI RESTRICTION
ENDONUCLEASE
(Pyrococcus
sp.
GI-H) 		4 / 6 GLU A 105
PHE A 108
TYR A 119
HIS A 121
 None
 1.27A 4uciA-3bm3A:
undetectable		 4uciA-3bm3A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3bm3 PSPGI RESTRICTION
ENDONUCLEASE
(Pyrococcus
sp.
GI-H) 		4 / 7 GLU A 105
PHE A 108
TYR A 119
HIS A 121
 None
 1.35A 4uciB-3bm3A:
undetectable		 4uciB-3bm3A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3bm3 PSPGI RESTRICTION
ENDONUCLEASE
(Pyrococcus
sp.
GI-H) 		4 / 5 GLY A 217
TYR A 213
GLU A 194
ASP A 216
 None
 1.10A 4xueA-3bm3A:
undetectable		 4xueA-3bm3A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 3bm3 PSPGI RESTRICTION
ENDONUCLEASE
(Pyrococcus
sp.
GI-H) 		4 / 8 ASN A 186
PHE A 256
PHE A 187
TRP A 188
 None
 1.41A 5amkA-3bm3A:
undetectable		 5amkA-3bm3A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 3bm3 PSPGI RESTRICTION
ENDONUCLEASE
(Pyrococcus
sp.
GI-H) 		4 / 8 ASN A 186
PHE A 256
PHE A 187
TYR A 213
 None
 1.44A 5amkA-3bm3A:
undetectable		 5amkA-3bm3A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 3bm3 PSPGI RESTRICTION
ENDONUCLEASE
(Pyrococcus
sp.
GI-H) 		4 / 7 VAL A  74
ARG A  96
TYR A  67
GLU A  71
 None
 1.04A 5umwB-3bm3A:
undetectable
5umwE-3bm3A:
undetectable		 5umwB-3bm3A:
16.08
5umwE-3bm3A:
16.08