SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bo5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		4 / 8 ARG A 166
ARG A 167
LEU A 159
GLU A 157
 None
 0.80A 1cmaA-3bo5A:
undetectable
1cmaB-3bo5A:
undetectable		 1cmaA-3bo5A:
14.44
1cmaB-3bo5A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		4 / 8 GLU A 163
ARG A 166
ARG A 167
GLU A 157
 None
 0.70A 1cmaA-3bo5A:
undetectable
1cmaB-3bo5A:
undetectable		 1cmaA-3bo5A:
14.44
1cmaB-3bo5A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 10 GLU A 163
ARG A 166
ARG A 167
GLU A 157
ALA A  49
 None
 1.24A 1cmcA-3bo5A:
undetectable
1cmcB-3bo5A:
undetectable		 1cmcA-3bo5A:
14.44
1cmcB-3bo5A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 10 GLU A 163
ARG A 166
ARG A 167
LEU A 159
GLU A 157
 None
 0.92A 1cmcA-3bo5A:
undetectable
1cmcB-3bo5A:
undetectable		 1cmcA-3bo5A:
14.44
1cmcB-3bo5A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		4 / 8 ASN A 203
GLY A 205
TYR A 246
VAL A 119
 None
 0.84A 1dbbH-3bo5A:
undetectable
1dbbL-3bo5A:
undetectable		 1dbbH-3bo5A:
18.66
1dbbL-3bo5A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		4 / 6 PHE A 150
ILE A 223
LYS A 229
ALA A 231
 None
 1.25A 1hk2A-3bo5A:
undetectable		 1hk2A-3bo5A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 ALA A  49
GLU A 163
ARG A 166
ARG A 167
GLU A 157
 None
 1.23A 1mj2A-3bo5A:
undetectable
1mj2B-3bo5A:
undetectable		 1mj2A-3bo5A:
14.08
1mj2B-3bo5A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLU A 163
ARG A 166
ARG A 167
LEU A 159
GLU A 157
 None
 0.95A 1mj2A-3bo5A:
undetectable
1mj2B-3bo5A:
undetectable		 1mj2A-3bo5A:
14.08
1mj2B-3bo5A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_0
(PROTEIN (METHIONINE
REPRESSOR))		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 9 GLU A 163
ARG A 166
ARG A 167
LEU A 159
GLU A 157
 None
 0.91A 1mj2A-3bo5A:
undetectable		 1mj2A-3bo5A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_0
(PROTEIN (METHIONINE
REPRESSOR))		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 9 GLU A 163
ARG A 166
ARG A 167
LEU A 159
GLU A 157
 None
 0.89A 1mj2C-3bo5A:
undetectable		 1mj2C-3bo5A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 ALA A  49
GLU A 163
ARG A 166
ARG A 167
GLU A 157
 None
 1.24A 1mj2C-3bo5A:
undetectable
1mj2D-3bo5A:
undetectable		 1mj2C-3bo5A:
14.08
1mj2D-3bo5A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLU A 163
ARG A 166
ARG A 167
LEU A 159
GLU A 157
 None
 0.93A 1mj2C-3bo5A:
undetectable
1mj2D-3bo5A:
undetectable		 1mj2C-3bo5A:
14.08
1mj2D-3bo5A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 11 GLU A 163
ARG A 166
ARG A 167
LEU A 159
ALA A  49
 None
 1.31A 1mjlA-3bo5A:
undetectable
1mjlB-3bo5A:
undetectable		 1mjlA-3bo5A:
14.08
1mjlB-3bo5A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 11 GLU A 163
ARG A 166
ARG A 167
LEU A 159
GLU A 157
 None
 0.71A 1mjlA-3bo5A:
undetectable
1mjlB-3bo5A:
undetectable		 1mjlA-3bo5A:
14.08
1mjlB-3bo5A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_0
(METHIONINE REPRESSOR)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 9 GLU A 163
ARG A 166
ARG A 167
LEU A 159
GLU A 157
 None
 0.94A 1mjoA-3bo5A:
undetectable		 1mjoA-3bo5A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_1
(METHIONINE REPRESSOR)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 9 GLU A 163
ARG A 166
ARG A 167
LEU A 159
GLU A 157
 None
 0.93A 1mjoB-3bo5A:
undetectable		 1mjoB-3bo5A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 ALA A  49
GLU A 163
ARG A 166
ARG A 167
GLU A 157
 None
 1.27A 1mjoC-3bo5A:
undetectable
1mjoD-3bo5A:
undetectable		 1mjoC-3bo5A:
14.08
1mjoD-3bo5A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLU A 163
ARG A 166
ARG A 167
LEU A 159
GLU A 157
 None
 0.92A 1mjoC-3bo5A:
undetectable
1mjoD-3bo5A:
undetectable		 1mjoC-3bo5A:
14.08
1mjoD-3bo5A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_0
(METHIONINE REPRESSOR)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 9 GLU A 163
ARG A 166
ARG A 167
LEU A 159
GLU A 157
 None
 0.92A 1mjoC-3bo5A:
undetectable		 1mjoC-3bo5A:
14.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2R3A_A_SAMA304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.34A 2r3aA-3bo5A:
26.2		 2r3aA-3bo5A:
30.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2R3A_A_SAMA304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 12 GLY A 136
TRP A 137
TYR A 178
HIS A 210
TYR A 248
CYH A 273
CYH A 275
LEU A 284
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
ZN  A 304 ( 2.3A)
SAH  A 305 (-4.5A)
 0.49A 2r3aA-3bo5A:
26.2		 2r3aA-3bo5A:
30.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 136
TRP A 137
ASN A 209
HIS A 210
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-3.4A)
None
ZN  A 304 ( 2.3A)
 1.12A 3ooiA-3bo5A:
20.9		 3ooiA-3bo5A:
30.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		9 / 12 GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
CYH A 273
CYH A 275
LEU A 284
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
ZN  A 304 ( 2.3A)
SAH  A 305 (-4.5A)
 0.64A 3ooiA-3bo5A:
20.9		 3ooiA-3bo5A:
30.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		7 / 12 GLY A 138
TYR A 178
HIS A 210
TYR A 248
CYH A 273
CYH A 275
LEU A 284
 None
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
ZN  A 304 ( 2.3A)
SAH  A 305 (-4.5A)
 1.18A 3ooiA-3bo5A:
20.9		 3ooiA-3bo5A:
30.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 138
TYR A 178
HIS A 210
TYR A 248
CYH A 275
 None
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.06A 3ooiA-3bo5A:
20.9		 3ooiA-3bo5A:
30.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 12 LYS A 135
GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
CYH A 273
 None
SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.41A 3opeA-3bo5A:
19.7		 3opeA-3bo5A:
28.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_B_SAMB8_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 9 GLY A 136
TRP A 137
TYR A 178
ASN A 209
TYR A 248
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
SAH  A 305 (-4.9A)
 0.45A 3opeB-3bo5A:
19.1		 3opeB-3bo5A:
28.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_B_SAMB8_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 9 LYS A 135
GLY A 136
TRP A 137
TYR A 178
ASN A 209
 None
SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
 0.86A 3opeB-3bo5A:
19.1		 3opeB-3bo5A:
28.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 136
TYR A 178
ASN A 209
HIS A 210
TYR A 248
 SAH  A 305 (-3.8A)
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
 0.91A 3qxyA-3bo5A:
6.2		 3qxyA-3bo5A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 136
TYR A 178
ASN A 209
HIS A 210
TYR A 248
 SAH  A 305 (-3.8A)
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
 0.88A 3rc0B-3bo5A:
6.1		 3rc0B-3bo5A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQ4_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 ASN A 209
HIS A 210
TYR A 248
CYH A 273
CYH A 275
 SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
ZN  A 304 ( 2.3A)
 0.48A 3rq4A-3bo5A:
8.9		 3rq4A-3bo5A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 ASN A 209
HIS A 210
TYR A 248
CYH A 273
CYH A 275
 SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
ZN  A 304 ( 2.3A)
 0.49A 3s8pA-3bo5A:
8.5		 3s8pA-3bo5A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 ASN A 209
HIS A 210
TYR A 248
CYH A 273
CYH A 275
 SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
ZN  A 304 ( 2.3A)
 0.51A 4bupA-3bo5A:
8.3		 4bupA-3bo5A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJ8_A_SAMA501_0
(N-LYSINE
METHYLTRANSFERASE
SETD8)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 10 LYS A 135
LEU A 139
ASN A 209
HIS A 210
TYR A 248
 None
None
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
 1.44A 4ij8A-3bo5A:
12.0
4ij8B-3bo5A:
11.8		 4ij8A-3bo5A:
21.16
4ij8B-3bo5A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJ8_A_SAMA501_0
(N-LYSINE
METHYLTRANSFERASE
SETD8)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 10 LYS A 135
TYR A 178
ASN A 209
HIS A 210
TYR A 248
 None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
 0.64A 4ij8A-3bo5A:
12.0
4ij8B-3bo5A:
11.8		 4ij8A-3bo5A:
21.16
4ij8B-3bo5A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJ8_B_SAMB501_0
(N-LYSINE
METHYLTRANSFERASE
SETD8)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 9 LYS A 135
TYR A 178
ASN A 209
HIS A 210
TYR A 248
 None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
 0.63A 4ij8A-3bo5A:
12.0
4ij8B-3bo5A:
11.8		 4ij8A-3bo5A:
21.16
4ij8B-3bo5A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 ILE A 238
THR A 141
LEU A 216
LEU A 208
PHE A 127
 None
 1.35A 4pbhA-3bo5A:
undetectable		 4pbhA-3bo5A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		7 / 12 LYS A 135
GLY A 136
TRP A 137
ASN A 209
HIS A 210
TYR A 248
CYH A 273
 None
SAH  A 305 (-3.8A)
None
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.25A 4ynmA-3bo5A:
20.1		 4ynmA-3bo5A:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		6 / 12 LYS A 135
GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 None
SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.47A 4ynmA-3bo5A:
20.1		 4ynmA-3bo5A:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.31A 4ynmB-3bo5A:
19.9		 4ynmB-3bo5A:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		7 / 12 GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.33A 4ynmB-3bo5A:
19.9		 4ynmB-3bo5A:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 138
TYR A 178
HIS A 210
TYR A 248
CYH A 273
 None
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.24A 4ynmB-3bo5A:
19.9		 4ynmB-3bo5A:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		6 / 12 GLY A 138
TYR A 178
HIS A 210
TYR A 248
CYH A 273
CYH A 275
 None
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
ZN  A 304 ( 2.3A)
 1.31A 4ynpA-3bo5A:
19.9		 4ynpA-3bo5A:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 138
TYR A 178
HIS A 210
TYR A 248
CYH A 275
 None
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.00A 4ynpA-3bo5A:
19.9		 4ynpA-3bo5A:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 12 LYS A 135
GLY A 136
TRP A 137
TYR A 178
HIS A 210
TYR A 248
CYH A 273
CYH A 275
 None
SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
ZN  A 304 ( 2.3A)
 0.45A 4ynpA-3bo5A:
19.9		 4ynpA-3bo5A:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		7 / 10 GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.50A 4ynpB-3bo5A:
19.3		 4ynpB-3bo5A:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		7 / 10 GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
CYH A 275
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.50A 4ynpB-3bo5A:
19.3		 4ynpB-3bo5A:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 10 GLY A 138
TYR A 178
HIS A 210
TYR A 248
CYH A 273
 None
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.26A 4ynpB-3bo5A:
19.3		 4ynpB-3bo5A:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 10 GLY A 138
TYR A 178
HIS A 210
TYR A 248
CYH A 275
 None
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.09A 4ynpB-3bo5A:
19.3		 4ynpB-3bo5A:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 138
TYR A 178
HIS A 210
TYR A 248
CYH A 273
 None
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.31A 4ypaA-3bo5A:
20.6		 4ypaA-3bo5A:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		6 / 12 LYS A 135
GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 None
SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.48A 4ypaA-3bo5A:
20.6		 4ypaA-3bo5A:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 12 LYS A 135
GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
CYH A 273
 None
SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.24A 4ypaA-3bo5A:
20.6		 4ypaA-3bo5A:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		7 / 12 LYS A 135
GLY A 136
TRP A 137
ASN A 209
HIS A 210
TYR A 248
CYH A 273
 None
SAH  A 305 (-3.8A)
None
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.34A 4ypaB-3bo5A:
19.2		 4ypaB-3bo5A:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		6 / 12 LYS A 135
GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 None
SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.42A 4ypaB-3bo5A:
19.2		 4ypaB-3bo5A:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		7 / 12 LYS A 135
GLY A 136
TRP A 137
ASN A 209
HIS A 210
TYR A 248
CYH A 273
 None
SAH  A 305 (-3.8A)
None
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.23A 4ypaC-3bo5A:
20.4		 4ypaC-3bo5A:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		6 / 12 LYS A 135
GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 None
SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.46A 4ypaC-3bo5A:
20.4		 4ypaC-3bo5A:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_D_SAMD2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 12 LYS A 135
GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
CYH A 273
 None
SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.38A 4ypaD-3bo5A:
19.6		 4ypaD-3bo5A:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_D_SAMD2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		7 / 12 LYS A 135
GLY A 136
TRP A 137
TYR A 178
HIS A 210
TYR A 248
CYH A 275
 None
SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.45A 4ypaD-3bo5A:
19.6		 4ypaD-3bo5A:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 138
TYR A 178
HIS A 210
TYR A 248
CYH A 273
 None
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.23A 4ypeA-3bo5A:
19.7		 4ypeA-3bo5A:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		6 / 12 LYS A 135
GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 None
SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.46A 4ypeA-3bo5A:
19.7		 4ypeA-3bo5A:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 12 LYS A 135
GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
CYH A 273
 None
SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.28A 4ypeA-3bo5A:
19.7		 4ypeA-3bo5A:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 11 LYS A 135
GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
CYH A 273
 None
SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.39A 4ypeB-3bo5A:
19.5		 4ypeB-3bo5A:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 138
TYR A 178
HIS A 210
TYR A 248
CYH A 273
 None
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.26A 4ypuA-3bo5A:
19.6		 4ypuA-3bo5A:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 12 LYS A 135
GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
CYH A 273
 None
SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.38A 4ypuA-3bo5A:
19.6		 4ypuA-3bo5A:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		7 / 11 LYS A 135
GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
 None
SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
 0.62A 4ypuB-3bo5A:
18.6		 4ypuB-3bo5A:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 PHE A 207
HIS A 210
TYR A 248
CYH A 273
CYH A 275
 None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
ZN  A 304 ( 2.3A)
 1.45A 5cprB-3bo5A:
7.2		 5cprB-3bo5A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		3 / 3 GLY A 276
CYH A 280
CYH A 212
 None
ZN  A 304 (-2.3A)
ZN  A 304 (-2.4A)
 0.97A 5inzB-3bo5A:
undetectable		 5inzB-3bo5A:
9.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.36A 5jhnA-3bo5A:
18.0		 5jhnA-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 12 GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.56A 5jhnA-3bo5A:
18.0		 5jhnA-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 12 GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
PHE A 286
LYS A 271
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
SAH  A 305 ( 4.1A)
 1.19A 5jhnA-3bo5A:
18.0		 5jhnA-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		6 / 12 GLY A 138
SER A 176
TYR A 178
HIS A 210
TYR A 248
CYH A 273
 None
SAH  A 305 ( 3.7A)
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.43A 5jhnA-3bo5A:
18.0		 5jhnA-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.40A 5jhnB-3bo5A:
26.2		 5jhnB-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 12 GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.60A 5jhnB-3bo5A:
26.2		 5jhnB-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		6 / 12 GLY A 138
SER A 176
TYR A 178
HIS A 210
TYR A 248
CYH A 273
 None
SAH  A 305 ( 3.7A)
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.42A 5jhnB-3bo5A:
26.2		 5jhnB-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.41A 5jinA-3bo5A:
17.9		 5jinA-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		7 / 12 GLY A 136
TRP A 137
TYR A 178
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.64A 5jinA-3bo5A:
17.9		 5jinA-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		6 / 12 GLY A 138
SER A 176
TYR A 178
HIS A 210
TYR A 248
CYH A 273
 None
SAH  A 305 ( 3.7A)
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.43A 5jinA-3bo5A:
17.9		 5jinA-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 SER A 176
TYR A 178
HIS A 210
TYR A 248
CYH A 273
 SAH  A 305 ( 3.7A)
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.26A 5jinB-3bo5A:
26.1		 5jinB-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		6 / 12 TRP A 137
ASN A 209
HIS A 210
TYR A 248
PHE A 286
LYS A 271
 None
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
SAH  A 305 ( 4.1A)
 0.96A 5jinB-3bo5A:
26.1		 5jinB-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		7 / 12 TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.59A 5jinB-3bo5A:
26.1		 5jinB-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.37A 5jiyA-3bo5A:
26.0		 5jiyA-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 12 GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.55A 5jiyA-3bo5A:
26.0		 5jiyA-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		6 / 12 GLY A 138
SER A 176
TYR A 178
HIS A 210
TYR A 248
CYH A 273
 None
SAH  A 305 ( 3.7A)
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.40A 5jiyA-3bo5A:
26.0		 5jiyA-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		6 / 12 TRP A 137
ASN A 209
HIS A 210
TYR A 248
PHE A 286
LYS A 271
 None
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
SAH  A 305 ( 4.1A)
 0.90A 5jiyA-3bo5A:
26.0		 5jiyA-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.40A 5jiyB-3bo5A:
26.1		 5jiyB-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 12 GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.62A 5jiyB-3bo5A:
26.1		 5jiyB-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		6 / 12 GLY A 138
SER A 176
TYR A 178
HIS A 210
TYR A 248
CYH A 273
 None
SAH  A 305 ( 3.7A)
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.41A 5jiyB-3bo5A:
26.1		 5jiyB-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		6 / 12 TRP A 137
ASN A 209
HIS A 210
TYR A 248
PHE A 286
LYS A 271
 None
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
SAH  A 305 ( 4.1A)
 0.97A 5jiyB-3bo5A:
26.1		 5jiyB-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JJ0_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.39A 5jj0A-3bo5A:
17.9		 5jj0A-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JJ0_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		7 / 12 GLY A 136
TRP A 137
TYR A 178
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.62A 5jj0A-3bo5A:
17.9		 5jj0A-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JJ0_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		6 / 12 GLY A 138
SER A 176
TYR A 178
HIS A 210
TYR A 248
CYH A 273
 None
SAH  A 305 ( 3.7A)
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.43A 5jj0A-3bo5A:
17.9		 5jj0A-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		7 / 12 GLY A 136
TRP A 137
ASN A 209
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.54A 5jj0B-3bo5A:
26.1		 5jj0B-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.43A 5jj0B-3bo5A:
26.1		 5jj0B-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 138
SER A 176
HIS A 210
TYR A 248
CYH A 273
 None
SAH  A 305 ( 3.7A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.46A 5jj0B-3bo5A:
26.1		 5jj0B-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		6 / 12 TRP A 137
ASN A 209
HIS A 210
TYR A 248
PHE A 286
LYS A 271
 None
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
SAH  A 305 ( 4.1A)
 0.97A 5jj0B-3bo5A:
26.1		 5jj0B-3bo5A:
32.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 ASN A 209
HIS A 210
TYR A 248
PHE A 286
LEU A 284
 SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
SAH  A 305 (-4.5A)
 1.02A 5kklB-3bo5A:
3.4		 5kklB-3bo5A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 136
ASN A 209
HIS A 210
TYR A 248
PHE A 286
 SAH  A 305 (-3.8A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
 0.61A 5kklB-3bo5A:
3.4		 5kklB-3bo5A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 136
TRP A 137
TYR A 178
HIS A 210
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
None
ZN  A 304 ( 2.3A)
 1.44A 5lsuA-3bo5A:
22.0		 5lsuA-3bo5A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		7 / 12 GLY A 136
TRP A 137
TYR A 178
HIS A 210
CYH A 273
CYH A 275
LEU A 284
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
None
ZN  A 304 ( 2.3A)
ZN  A 304 ( 2.3A)
SAH  A 305 (-4.5A)
 0.52A 5lsuA-3bo5A:
22.0		 5lsuA-3bo5A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 138
TYR A 178
HIS A 210
CYH A 273
CYH A 275
 None
SAH  A 305 (-4.0A)
None
ZN  A 304 ( 2.3A)
ZN  A 304 ( 2.3A)
 1.27A 5lsuA-3bo5A:
22.0		 5lsuA-3bo5A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		6 / 12 GLY A 136
TRP A 137
TYR A 178
HIS A 210
CYH A 275
LEU A 284
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
None
ZN  A 304 ( 2.3A)
SAH  A 305 (-4.5A)
 0.63A 5lsuB-3bo5A:
21.5		 5lsuB-3bo5A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 138
TYR A 178
HIS A 210
CYH A 275
LEU A 284
 None
SAH  A 305 (-4.0A)
None
ZN  A 304 ( 2.3A)
SAH  A 305 (-4.5A)
 1.13A 5lsuB-3bo5A:
21.5		 5lsuB-3bo5A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		3 / 3 ASN A 209
TYR A 248
CYH A 273
 SAH  A 305 (-3.4A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.17A 5lsuB-3bo5A:
21.5		 5lsuB-3bo5A:
27.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.35A 5t0kA-3bo5A:
26.3		 5t0kA-3bo5A:
33.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 12 GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.56A 5t0kA-3bo5A:
26.3		 5t0kA-3bo5A:
33.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		6 / 12 GLY A 138
SER A 176
TYR A 178
HIS A 210
TYR A 248
CYH A 273
 None
SAH  A 305 ( 3.7A)
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.35A 5t0kA-3bo5A:
26.3		 5t0kA-3bo5A:
33.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		6 / 12 GLY A 138
TYR A 178
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 None
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.17A 5t0kA-3bo5A:
26.3		 5t0kA-3bo5A:
33.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0K_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		7 / 12 GLY A 136
TRP A 137
ASN A 209
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.49A 5t0kB-3bo5A:
26.1		 5t0kB-3bo5A:
33.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0K_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		7 / 12 GLY A 136
TRP A 137
ASN A 209
HIS A 210
TYR A 248
PHE A 286
LYS A 271
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
SAH  A 305 ( 4.1A)
 0.98A 5t0kB-3bo5A:
26.1		 5t0kB-3bo5A:
33.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0K_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.35A 5t0kB-3bo5A:
26.1		 5t0kB-3bo5A:
33.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0K_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 138
SER A 176
HIS A 210
TYR A 248
CYH A 273
 None
SAH  A 305 ( 3.7A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.42A 5t0kB-3bo5A:
26.1		 5t0kB-3bo5A:
33.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0M_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 SER A 176
TYR A 178
HIS A 210
TYR A 248
CYH A 273
 SAH  A 305 ( 3.7A)
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.29A 5t0mA-3bo5A:
26.5		 5t0mA-3bo5A:
33.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0M_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		6 / 12 TRP A 137
ASN A 209
HIS A 210
TYR A 248
PHE A 286
LYS A 271
 None
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
SAH  A 305 ( 4.1A)
 0.94A 5t0mA-3bo5A:
26.5		 5t0mA-3bo5A:
33.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0M_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		7 / 12 TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.57A 5t0mA-3bo5A:
26.5		 5t0mA-3bo5A:
33.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.35A 5t0mB-3bo5A:
26.3		 5t0mB-3bo5A:
33.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 12 GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.55A 5t0mB-3bo5A:
26.3		 5t0mB-3bo5A:
33.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		6 / 12 GLY A 138
SER A 176
TYR A 178
HIS A 210
TYR A 248
CYH A 273
 None
SAH  A 305 ( 3.7A)
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.43A 5t0mB-3bo5A:
26.3		 5t0mB-3bo5A:
33.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TEG_A_SAMA401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 9 LYS A 135
LEU A 139
ASN A 209
HIS A 210
TYR A 248
 None
None
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
 1.46A 5tegA-3bo5A:
12.5
5tegD-3bo5A:
undetectable		 5tegA-3bo5A:
22.41
5tegD-3bo5A:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TEG_A_SAMA401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 9 LYS A 135
TYR A 178
ASN A 209
HIS A 210
TYR A 248
 None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
 0.35A 5tegA-3bo5A:
12.5
5tegD-3bo5A:
undetectable		 5tegA-3bo5A:
22.41
5tegD-3bo5A:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TEG_B_SAMB401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		6 / 10 LYS A 135
GLY A 136
TYR A 178
ASN A 209
HIS A 210
TYR A 248
 None
SAH  A 305 (-3.8A)
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
 0.35A 5tegB-3bo5A:
13.3
5tegE-3bo5A:
undetectable		 5tegB-3bo5A:
22.41
5tegE-3bo5A:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TEG_B_SAMB401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 10 LYS A 135
LEU A 139
ASN A 209
HIS A 210
TYR A 248
 None
None
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
 1.46A 5tegB-3bo5A:
13.3
5tegE-3bo5A:
undetectable		 5tegB-3bo5A:
22.41
5tegE-3bo5A:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TQR_B_SAMB8009_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2, POLYCOMB
PROTEIN SUZ12)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 10 GLY A 136
TYR A 178
ASN A 209
HIS A 210
TYR A 248
 SAH  A 305 (-3.8A)
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
 0.41A 5tqrB-3bo5A:
13.7		 5tqrB-3bo5A:
15.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 11 GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.41A 5ttfA-3bo5A:
26.0		 5ttfA-3bo5A:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 11 GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.59A 5ttfA-3bo5A:
26.0		 5ttfA-3bo5A:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.44A 5ttfB-3bo5A:
26.2		 5ttfB-3bo5A:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 12 GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.61A 5ttfB-3bo5A:
26.2		 5ttfB-3bo5A:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		7 / 12 GLY A 136
TRP A 137
ASN A 209
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.72A 5ttfC-3bo5A:
26.1		 5ttfC-3bo5A:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 11 GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.49A 5ttfD-3bo5A:
18.0		 5ttfD-3bo5A:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 11 GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.71A 5ttfD-3bo5A:
18.0		 5ttfD-3bo5A:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.44A 5ttgA-3bo5A:
18.4		 5ttgA-3bo5A:
32.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 12 GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.63A 5ttgA-3bo5A:
18.4		 5ttgA-3bo5A:
32.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 11 GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.46A 5ttgB-3bo5A:
17.9		 5ttgB-3bo5A:
32.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 11 GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.65A 5ttgB-3bo5A:
17.9		 5ttgB-3bo5A:
32.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 12 GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.60A 5tuyA-3bo5A:
26.5		 5tuyA-3bo5A:
32.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.43A 5tuyB-3bo5A:
17.9		 5tuyB-3bo5A:
32.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 12 GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.57A 5tuyB-3bo5A:
17.9		 5tuyB-3bo5A:
32.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 SER A 176
TYR A 178
HIS A 210
TYR A 248
CYH A 273
 SAH  A 305 ( 3.7A)
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.42A 5tuyB-3bo5A:
17.9		 5tuyB-3bo5A:
32.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUZ_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 12 GLY A 136
TRP A 137
ASN A 209
HIS A 210
TYR A 248
PHE A 286
CYH A 273
CYH A 275
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
ZN  A 304 ( 2.3A)
 0.60A 5tuzA-3bo5A:
18.5		 5tuzA-3bo5A:
32.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUZ_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.44A 5tuzA-3bo5A:
18.5		 5tuzA-3bo5A:
32.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUZ_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 TRP A 137
ASN A 209
HIS A 210
TYR A 248
CYH A 273
 None
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.23A 5tuzA-3bo5A:
18.5		 5tuzA-3bo5A:
32.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.42A 5tuzB-3bo5A:
14.3		 5tuzB-3bo5A:
32.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 12 GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.63A 5tuzB-3bo5A:
14.3		 5tuzB-3bo5A:
32.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		6 / 11 GLY A 136
TRP A 137
ASN A 209
HIS A 210
TYR A 248
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.26A 5updA-3bo5A:
20.7		 5updA-3bo5A:
31.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		9 / 11 GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
CYH A 273
CYH A 275
LEU A 284
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
ZN  A 304 ( 2.3A)
SAH  A 305 (-4.5A)
 0.48A 5updA-3bo5A:
20.7		 5updA-3bo5A:
31.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		6 / 11 GLY A 138
TYR A 178
HIS A 210
TYR A 248
CYH A 273
CYH A 275
 None
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
ZN  A 304 ( 2.3A)
 1.38A 5updA-3bo5A:
20.7		 5updA-3bo5A:
31.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		6 / 12 GLY A 138
TYR A 178
HIS A 210
TYR A 248
CYH A 273
LEU A 284
 None
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
SAH  A 305 (-4.5A)
 1.23A 5v21A-3bo5A:
20.0		 5v21A-3bo5A:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		6 / 12 LYS A 135
GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 None
SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.35A 5v21A-3bo5A:
20.0		 5v21A-3bo5A:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		9 / 12 LYS A 135
GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
CYH A 273
LEU A 284
 None
SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
SAH  A 305 (-4.5A)
 0.43A 5v21A-3bo5A:
20.0		 5v21A-3bo5A:
27.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.42A 5v9iA-3bo5A:
26.1		 5v9iA-3bo5A:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 12 GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.62A 5v9iA-3bo5A:
26.1		 5v9iA-3bo5A:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 11 GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.45A 5v9iB-3bo5A:
26.1		 5v9iB-3bo5A:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 11 GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.65A 5v9iB-3bo5A:
26.1		 5v9iB-3bo5A:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 11 GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.50A 5v9iC-3bo5A:
26.0		 5v9iC-3bo5A:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 11 GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.70A 5v9iC-3bo5A:
26.0		 5v9iC-3bo5A:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		7 / 12 GLY A 136
TRP A 137
TYR A 178
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.81A 5v9iD-3bo5A:
26.0		 5v9iD-3bo5A:
33.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.40A 5v9jA-3bo5A:
18.4		 5v9jA-3bo5A:
32.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 12 GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.62A 5v9jA-3bo5A:
18.4		 5v9jA-3bo5A:
32.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.45A 5v9jB-3bo5A:
26.4		 5v9jB-3bo5A:
32.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 12 GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.64A 5v9jB-3bo5A:
26.4		 5v9jB-3bo5A:
32.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.36A 5vscA-3bo5A:
26.3		 5vscA-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 12 GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.57A 5vscA-3bo5A:
26.3		 5vscA-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		6 / 12 GLY A 136
TRP A 137
ASN A 209
HIS A 210
TYR A 248
CYH A 275
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.26A 5vscB-3bo5A:
17.9		 5vscB-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 12 GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.57A 5vscB-3bo5A:
17.9		 5vscB-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSD_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		7 / 12 GLY A 136
TRP A 137
ASN A 209
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.63A 5vsdA-3bo5A:
18.3		 5vsdA-3bo5A:
32.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSD_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.43A 5vsdA-3bo5A:
18.3		 5vsdA-3bo5A:
32.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.45A 5vsdB-3bo5A:
12.6		 5vsdB-3bo5A:
32.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 12 GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.65A 5vsdB-3bo5A:
12.6		 5vsdB-3bo5A:
32.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.37A 5vseA-3bo5A:
26.4		 5vseA-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 12 GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.55A 5vseA-3bo5A:
26.4		 5vseA-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		6 / 12 GLY A 136
TRP A 137
ASN A 209
HIS A 210
TYR A 248
CYH A 275
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.26A 5vseB-3bo5A:
26.1		 5vseB-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 12 GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.55A 5vseB-3bo5A:
26.1		 5vseB-3bo5A:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSF_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		7 / 12 GLY A 136
TRP A 137
ASN A 209
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.62A 5vsfA-3bo5A:
18.4		 5vsfA-3bo5A:
32.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSF_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.45A 5vsfA-3bo5A:
18.4		 5vsfA-3bo5A:
32.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.43A 5vsfB-3bo5A:
18.4		 5vsfB-3bo5A:
32.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 12 GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
PHE A 286
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.61A 5vsfB-3bo5A:
18.4		 5vsfB-3bo5A:
32.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 136
TRP A 137
ASN A 209
HIS A 210
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-3.4A)
None
ZN  A 304 ( 2.3A)
 1.10A 6a5kA-3bo5A:
24.7		 6a5kA-3bo5A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 12 GLY A 136
TRP A 137
ASN A 209
HIS A 210
TYR A 248
CYH A 273
CYH A 275
LEU A 284
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
ZN  A 304 ( 2.3A)
SAH  A 305 (-4.5A)
 0.38A 6a5kA-3bo5A:
24.7		 6a5kA-3bo5A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 136
TRP A 137
HIS A 210
TYR A 248
CYH A 275
 SAH  A 305 (-3.8A)
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.40A 6a5kA-3bo5A:
24.7		 6a5kA-3bo5A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		6 / 12 GLY A 138
HIS A 210
TYR A 248
CYH A 273
CYH A 275
LEU A 284
 None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
ZN  A 304 ( 2.3A)
SAH  A 305 (-4.5A)
 1.13A 6a5kA-3bo5A:
24.7		 6a5kA-3bo5A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		6 / 12 TRP A 137
ASN A 209
HIS A 210
TYR A 248
LYS A 271
LEU A 284
 None
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
SAH  A 305 ( 4.1A)
SAH  A 305 (-4.5A)
 1.24A 6a5kA-3bo5A:
24.7		 6a5kA-3bo5A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 136
TRP A 137
ASN A 209
HIS A 210
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-3.4A)
None
ZN  A 304 ( 2.3A)
 1.18A 6a5mA-3bo5A:
25.3		 6a5mA-3bo5A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		9 / 12 GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
CYH A 273
CYH A 275
LEU A 284
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
ZN  A 304 ( 2.3A)
SAH  A 305 (-4.5A)
 0.54A 6a5mA-3bo5A:
25.3		 6a5mA-3bo5A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		7 / 12 GLY A 138
TYR A 178
HIS A 210
TYR A 248
CYH A 273
CYH A 275
LEU A 284
 None
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
ZN  A 304 ( 2.3A)
SAH  A 305 (-4.5A)
 1.30A 6a5mA-3bo5A:
25.3		 6a5mA-3bo5A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 138
TYR A 178
HIS A 210
TYR A 248
CYH A 275
 None
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.04A 6a5mA-3bo5A:
25.3		 6a5mA-3bo5A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		6 / 12 TRP A 137
TYR A 178
HIS A 210
TYR A 248
LYS A 271
LEU A 284
 None
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
SAH  A 305 ( 4.1A)
SAH  A 305 (-4.5A)
 1.29A 6a5mA-3bo5A:
25.3		 6a5mA-3bo5A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		7 / 11 GLY A 136
TRP A 137
ASN A 209
HIS A 210
TYR A 248
CYH A 273
CYH A 275
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
ZN  A 304 ( 2.3A)
 0.89A 6agoA-3bo5A:
19.2		 6agoA-3bo5A:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		7 / 11 GLY A 136
TYR A 178
ASN A 209
HIS A 210
TYR A 248
CYH A 273
CYH A 275
 SAH  A 305 (-3.8A)
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
ZN  A 304 ( 2.3A)
 0.94A 6agoA-3bo5A:
19.2		 6agoA-3bo5A:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		6 / 11 GLY A 138
TYR A 178
HIS A 210
TYR A 248
CYH A 273
CYH A 275
 None
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
ZN  A 304 ( 2.3A)
 1.43A 6agoA-3bo5A:
19.2		 6agoA-3bo5A:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 11 LYS A 135
GLY A 136
TRP A 137
ASN A 209
CYH A 275
 None
SAH  A 305 (-3.8A)
None
SAH  A 305 (-3.4A)
ZN  A 304 ( 2.3A)
 1.39A 6agoA-3bo5A:
19.2		 6agoA-3bo5A:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 11 LYS A 135
GLY A 136
TYR A 178
ASN A 209
CYH A 275
 None
SAH  A 305 (-3.8A)
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
ZN  A 304 ( 2.3A)
 1.39A 6agoA-3bo5A:
19.2		 6agoA-3bo5A:
28.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BP4_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 12 LYS A 135
GLY A 136
TRP A 137
ARG A 206
HIS A 210
TYR A 248
CYH A 275
LEU A 284
 None
SAH  A 305 (-3.8A)
None
None
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
SAH  A 305 (-4.5A)
 0.74A 6bp4A-3bo5A:
25.2		 6bp4A-3bo5A:
32.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		6 / 12 GLY A 138
TYR A 178
HIS A 210
TYR A 248
CYH A 273
CYH A 275
 None
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
ZN  A 304 ( 2.3A)
 1.33A 6bp4B-3bo5A:
26.0		 6bp4B-3bo5A:
32.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 12 GLY A 138
TYR A 178
HIS A 210
TYR A 248
CYH A 275
 None
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 0.90A 6bp4B-3bo5A:
26.0		 6bp4B-3bo5A:
32.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		9 / 12 LYS A 135
GLY A 136
TRP A 137
TYR A 178
HIS A 210
TYR A 248
CYH A 273
CYH A 275
LEU A 284
 None
SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
ZN  A 304 ( 2.3A)
SAH  A 305 (-4.5A)
 0.50A 6bp4B-3bo5A:
26.0		 6bp4B-3bo5A:
32.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		9 / 11 GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
CYH A 273
CYH A 275
LEU A 284
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
ZN  A 304 ( 2.3A)
SAH  A 305 (-4.5A)
 0.32A 6cenA-3bo5A:
20.8		 6cenA-3bo5A:
31.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		5 / 11 GLY A 138
TYR A 178
HIS A 210
TYR A 248
CYH A 275
 None
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.25A 6cenA-3bo5A:
20.8		 6cenA-3bo5A:
31.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		6 / 12 TRP A 137
SER A 176
TYR A 178
PHE A 207
ASN A 209
HIS A 210
 None
SAH  A 305 ( 3.7A)
SAH  A 305 (-4.0A)
None
SAH  A 305 (-3.4A)
None
 0.76A 6chgC-3bo5A:
8.8		 6chgC-3bo5A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		6 / 12 TRP A 137
SER A 176
TYR A 178
PHE A 207
HIS A 210
LEU A 284
 None
SAH  A 305 ( 3.7A)
SAH  A 305 (-4.0A)
None
None
SAH  A 305 (-4.5A)
 1.00A 6chgC-3bo5A:
8.8		 6chgC-3bo5A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		6 / 12 LYS A 135
GLY A 136
TRP A 137
ASN A 209
HIS A 210
CYH A 273
 None
SAH  A 305 (-3.8A)
None
SAH  A 305 (-3.4A)
None
ZN  A 304 ( 2.3A)
 1.31A 6ineA-3bo5A:
18.0		 6ineA-3bo5A:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens) 		8 / 12 LYS A 135
GLY A 136
TRP A 137
ASN A 209
HIS A 210
TYR A 248
CYH A 273
CYH A 275
 None
SAH  A 305 (-3.8A)
None
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
ZN  A 304 ( 2.3A)
 0.48A 6ineA-3bo5A:
18.0		 6ineA-3bo5A:
28.21