SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bpt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
5 / 9 ALA A 210
PHE A 259
GLY A 192
LEU A 202
PHE A 200
None
1.06A 1nr6A-3bptA:
undetectable
1nr6A-3bptA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
4 / 4 ALA A 159
VAL A 207
ALA A 213
HIS A 215
None
1.19A 1q23A-3bptA:
undetectable
1q23A-3bptA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
4 / 4 ALA A 159
VAL A 207
ALA A 213
HIS A 215
None
1.22A 1q23F-3bptA:
undetectable
1q23F-3bptA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
4 / 4 ALA A 159
VAL A 207
ALA A 213
HIS A 215
None
1.18A 1q23K-3bptA:
undetectable
1q23K-3bptA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
4 / 8 ASN A 125
TYR A 122
GLY A 145
GLY A  98
None
None
HIU  A 502 ( 3.7A)
HIU  A 502 ( 3.7A)
0.80A 1rukH-3bptA:
undetectable
1rukL-3bptA:
undetectable
1rukH-3bptA:
19.23
1rukL-3bptA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
5 / 11 PHE A 117
PHE A 118
GLY A  97
ILE A 172
LEU A 174
None
HIU  A 502 (-4.8A)
HIU  A 502 ( 3.5A)
QUE  A 501 (-3.9A)
HIU  A 502 (-4.9A)
1.05A 1z11A-3bptA:
undetectable
1z11A-3bptA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
5 / 11 PHE A 117
PHE A 118
GLY A  97
ILE A 172
LEU A 174
None
HIU  A 502 (-4.8A)
HIU  A 502 ( 3.5A)
QUE  A 501 (-3.9A)
HIU  A 502 (-4.9A)
1.05A 1z11B-3bptA:
undetectable
1z11B-3bptA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
5 / 12 LEU A 322
LEU A 326
GLU A 121
GLY A 149
ARG A 157
None
None
HIU  A 502 (-2.9A)
None
None
1.12A 2bm9A-3bptA:
undetectable
2bm9A-3bptA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
5 / 12 LEU A 322
LEU A 326
GLU A 121
GLY A 149
ARG A 157
None
None
HIU  A 502 (-2.9A)
None
None
1.14A 2bm9B-3bptA:
undetectable
2bm9B-3bptA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
5 / 12 LEU A 322
LEU A 326
GLU A 121
GLY A 149
ARG A 157
None
None
HIU  A 502 (-2.9A)
None
None
1.10A 2bm9D-3bptA:
undetectable
2bm9D-3bptA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
5 / 12 PHE A 117
LEU A 124
LEU A  60
LEU A  51
ILE A  49
None
1.21A 2bxpA-3bptA:
1.9
2bxpA-3bptA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
5 / 12 LEU A 202
ALA A 166
ILE A 142
ALA A 210
PHE A 259
None
0.93A 2ejtA-3bptA:
undetectable
2ejtA-3bptA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
5 / 9 SER A 151
ILE A 139
ALA A 213
GLY A 192
LEU A 187
None
1.12A 2v0mB-3bptA:
undetectable
2v0mB-3bptA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
4 / 5 LEU A 284
GLY A 288
GLU A 282
CYH A 271
None
1.15A 3aiaA-3bptA:
undetectable
3aiaB-3bptA:
undetectable
3aiaA-3bptA:
18.00
3aiaB-3bptA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
5 / 12 GLY A  97
VAL A 148
ILE A 103
ASP A  99
LEU A 174
HIU  A 502 ( 3.5A)
None
None
None
HIU  A 502 (-4.9A)
1.12A 3cjtG-3bptA:
undetectable
3cjtG-3bptA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
5 / 12 GLY A 180
VAL A 178
ILE A 309
SER A 306
ILE A 103
None
HIU  A 502 (-4.6A)
None
None
None
1.01A 3frqB-3bptA:
undetectable
3frqB-3bptA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
4 / 7 TYR A 122
VAL A 178
ILE A 100
GLY A 146
None
HIU  A 502 (-4.6A)
QUE  A 501 ( 3.8A)
HIU  A 502 (-2.7A)
1.00A 3gssA-3bptA:
undetectable
3gssA-3bptA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
4 / 7 TYR A 122
VAL A 178
ILE A 100
GLY A 146
None
HIU  A 502 (-4.6A)
QUE  A 501 ( 3.8A)
HIU  A 502 (-2.7A)
1.00A 3gssB-3bptA:
undetectable
3gssB-3bptA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
4 / 6 LEU A  60
GLU A 121
ASN A 125
PHE A  94
None
HIU  A 502 (-2.9A)
None
None
1.46A 3i9jB-3bptA:
undetectable
3i9jB-3bptA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
5 / 12 TYR A 135
GLY A  88
ALA A  93
ILE A  49
PRO A  54
None
1.00A 3jayA-3bptA:
undetectable
3jayA-3bptA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
4 / 5 ILE A 100
PHE A 342
ASP A 341
GLU A 344
QUE  A 501 ( 3.8A)
None
None
None
1.03A 3kp6A-3bptA:
undetectable
3kp6B-3bptA:
undetectable
3kp6A-3bptA:
20.33
3kp6B-3bptA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
4 / 8 CYH A 336
PHE A 342
LEU A 332
ASP A 177
None
None
None
HIU  A 502 (-2.8A)
1.06A 3m0wE-3bptA:
0.3
3m0wF-3bptA:
undetectable
3m0wG-3bptA:
undetectable
3m0wH-3bptA:
undetectable
3m0wE-3bptA:
16.45
3m0wF-3bptA:
16.45
3m0wG-3bptA:
16.45
3m0wH-3bptA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
4 / 4 LEU A 150
GLY A 149
GLY A 147
THR A 143
None
0.95A 3si7A-3bptA:
undetectable
3si7A-3bptA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
5 / 12 GLN A 313
PHE A 183
GLY A 181
ALA A 166
GLY A 199
None
1.19A 3v3oA-3bptA:
undetectable
3v3oA-3bptA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
3 / 3 GLN A  67
THR A  61
ASN A  63
None
0.81A 3v4tE-3bptA:
0.4
3v4tE-3bptA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
4 / 7 PHE A 194
PHE A 272
PHE A 291
ALA A 292
None
0.91A 4ejgA-3bptA:
undetectable
4ejgA-3bptA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
4 / 8 PHE A 194
PHE A 272
PHE A 291
ALA A 292
None
0.94A 4ejgB-3bptA:
undetectable
4ejgB-3bptA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
4 / 8 GLY A 192
MET A 167
PHE A 165
ILE A 212
None
0.80A 4j4vC-3bptA:
undetectable
4j4vC-3bptA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
5 / 12 GLY A 204
ALA A 213
CYH A 163
HIS A 140
ILE A 139
None
1.05A 4krhA-3bptA:
undetectable
4krhA-3bptA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
5 / 12 GLY A 179
GLY A 180
LEU A 184
GLY A 149
VAL A 148
None
0.75A 4o33A-3bptA:
undetectable
4o33A-3bptA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
5 / 11 ILE A  86
LEU A  72
HIS A 153
ALA A 127
LEU A 124
None
1.07A 4p65E-3bptA:
undetectable
4p65F-3bptA:
undetectable
4p65J-3bptA:
undetectable
4p65L-3bptA:
undetectable
4p65E-3bptA:
4.74
4p65F-3bptA:
6.71
4p65J-3bptA:
6.71
4p65L-3bptA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
5 / 12 GLY A 199
ILE A 142
ALA A  96
MET A 144
GLY A 145
None
None
QUE  A 501 ( 4.0A)
None
HIU  A 502 ( 3.7A)
1.04A 4r29D-3bptA:
undetectable
4r29D-3bptA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
4 / 7 ILE A 280
PHE A 175
ILE A 309
ASN A 300
None
0.93A 5hieC-3bptA:
undetectable
5hieC-3bptA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
5 / 12 VAL A 178
VAL A 148
LEU A 184
LEU A 350
MET A 302
HIU  A 502 (-4.6A)
None
None
QUE  A 501 (-4.6A)
None
1.18A 5hv1A-3bptA:
undetectable
5hv1A-3bptA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
5 / 12 GLY A 181
GLY A 179
PRO A 185
LEU A 372
PHE A 376
None
1.11A 5ybbA-3bptA:
undetectable
5ybbA-3bptA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJS_A_SALA603_0
(VICILIN-LIKE
ANTIMICROBIAL
PEPTIDES 2-2)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
5 / 11 PHE A 117
GLY A  98
TYR A 122
ASN A 125
GLY A  97
None
HIU  A 502 ( 3.7A)
None
None
HIU  A 502 ( 3.5A)
1.21A 5yjsA-3bptA:
undetectable
5yjsA-3bptA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
5 / 7 GLY A 180
GLY A 179
GLY A 149
GLY A 147
GLY A 146
None
None
None
None
HIU  A 502 (-2.7A)
0.84A 6ag0A-3bptA:
undetectable
6ag0A-3bptA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
4 / 4 ILE A  86
LEU A  72
HIS A 153
ALA A 127
None
1.02A 6ck2C-3bptA:
undetectable
6ck2D-3bptA:
undetectable
6ck2C-3bptA:
4.74
6ck2D-3bptA:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo
sapiens)
5 / 12 LEU A 314
PRO A 176
HIS A 153
THR A 143
GLY A 147
None
1.16A 6mn8A-3bptA:
undetectable
6mn8A-3bptA:
21.46