SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bq3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3bq3 DEFECTIVE IN CULLIN
NEDDYLATION PROTEIN
1
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 116
GLN A 137
THR A 133
THR A 109
 None
 1.20A 2zj0B-3bq3A:
undetectable		 2zj0B-3bq3A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3bq3 DEFECTIVE IN CULLIN
NEDDYLATION PROTEIN
1
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 116
GLN A 137
THR A 133
THR A 109
 None
 1.25A 2zj0C-3bq3A:
undetectable		 2zj0C-3bq3A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3bq3 DEFECTIVE IN CULLIN
NEDDYLATION PROTEIN
1
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 116
GLN A 137
THR A 133
THR A 109
 None
 1.19A 2zj0D-3bq3A:
undetectable		 2zj0D-3bq3A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3bq3 DEFECTIVE IN CULLIN
NEDDYLATION PROTEIN
1
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 116
GLN A 137
THR A 133
THR A 109
 None
 1.22A 3ce6B-3bq3A:
undetectable		 3ce6B-3bq3A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3bq3 DEFECTIVE IN CULLIN
NEDDYLATION PROTEIN
1
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 149
GLY A 138
PRO A  72
VAL A  78
LEU A 115
 None
 1.16A 3elzC-3bq3A:
undetectable		 3elzC-3bq3A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 3bq3 DEFECTIVE IN CULLIN
NEDDYLATION PROTEIN
1
(Saccharomyces
cerevisiae) 		3 / 3 GLU A  80
TYR A  50
GLU A  54
 None
 0.84A 4ryaA-3bq3A:
undetectable		 4ryaA-3bq3A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_B_QDNB602_1
(CYTOCHROME P450 2D6)		 3bq3 DEFECTIVE IN CULLIN
NEDDYLATION PROTEIN
1
(Saccharomyces
cerevisiae) 		5 / 9 GLU A 198
GLN A 196
PHE A 194
ASP A 106
ALA A 108
 None
 1.37A 4wnuB-3bq3A:
undetectable		 4wnuB-3bq3A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 3bq3 DEFECTIVE IN CULLIN
NEDDYLATION PROTEIN
1
(Saccharomyces
cerevisiae) 		5 / 10 GLU A 198
GLN A 196
PHE A 194
ASP A 106
ALA A 108
 None
 1.36A 4wnuD-3bq3A:
undetectable		 4wnuD-3bq3A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 3bq3 DEFECTIVE IN CULLIN
NEDDYLATION PROTEIN
1
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 131
LEU A 116
ILE A  83
PHE A  88
 None
 1.09A 4y4dA-3bq3A:
undetectable		 4y4dA-3bq3A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FEP_A_SAMA407_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 3bq3 DEFECTIVE IN CULLIN
NEDDYLATION PROTEIN
1
(Saccharomyces
cerevisiae) 		5 / 12 TYR A  50
GLN A  77
LEU A 131
ARG A 127
ILE A  55
 None
 1.46A 5fepA-3bq3A:
undetectable		 5fepA-3bq3A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FES_A_SAMA408_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 3bq3 DEFECTIVE IN CULLIN
NEDDYLATION PROTEIN
1
(Saccharomyces
cerevisiae) 		5 / 12 TYR A  50
GLN A  77
LEU A 131
ARG A 127
ILE A  55
 None
 1.47A 5fesA-3bq3A:
undetectable		 5fesA-3bq3A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3bq3 DEFECTIVE IN CULLIN
NEDDYLATION PROTEIN
1
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 127
LEU A 131
PHE A 135
 None
 0.44A 6nknP-3bq3A:
undetectable		 6nknP-3bq3A:
23.68