SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bq8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 3bq8 SENSOR PROTEIN PHOQ
(Escherichia
coli) 		4 / 7 GLU A 123
GLU A 154
GLU A 184
GLU A 121
 None
 1.20A 1knyA-3bq8A:
undetectable
1knyB-3bq8A:
undetectable		 1knyA-3bq8A:
18.35
1knyB-3bq8A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 3bq8 SENSOR PROTEIN PHOQ
(Escherichia
coli) 		4 / 8 VAL A 176
ASP A 112
TRP A 113
LEU A 105
 None
 1.10A 1pk2A-3bq8A:
undetectable		 1pk2A-3bq8A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 3bq8 SENSOR PROTEIN PHOQ
(Escherichia
coli) 		4 / 5 ASP A  90
LEU A 173
LYS A 172
MET A 170
 None
 1.30A 2gj5A-3bq8A:
undetectable		 2gj5A-3bq8A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 3bq8 SENSOR PROTEIN PHOQ
(Escherichia
coli) 		4 / 5 LEU A 132
ASP A 125
MET A 106
LEU A  87
 None
 1.24A 2jfaA-3bq8A:
undetectable		 2jfaA-3bq8A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 3bq8 SENSOR PROTEIN PHOQ
(Escherichia
coli) 		4 / 5 LEU A 132
ASP A 125
MET A 106
LEU A  87
 None
 1.19A 2qxsA-3bq8A:
undetectable		 2qxsA-3bq8A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 3bq8 SENSOR PROTEIN PHOQ
(Escherichia
coli) 		4 / 5 LEU A 132
ASP A 125
MET A 106
LEU A  87
 None
 1.20A 2qxsB-3bq8A:
undetectable		 2qxsB-3bq8A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3bq8 SENSOR PROTEIN PHOQ
(Escherichia
coli) 		5 / 10 MET A  85
ALA A  98
LEU A  95
VAL A 102
ILE A 109
 None
 1.21A 3fl9A-3bq8A:
undetectable		 3fl9A-3bq8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3bq8 SENSOR PROTEIN PHOQ
(Escherichia
coli) 		5 / 10 MET A  85
ALA A  98
LEU A  95
VAL A 102
ILE A 109
 None
 1.06A 3fl9E-3bq8A:
undetectable		 3fl9E-3bq8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3bq8 SENSOR PROTEIN PHOQ
(Escherichia
coli) 		5 / 10 MET A  85
ALA A  98
LEU A  95
VAL A 102
ILE A 109
 None
 1.12A 3fl9F-3bq8A:
undetectable		 3fl9F-3bq8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3bq8 SENSOR PROTEIN PHOQ
(Escherichia
coli) 		4 / 6 ILE A  88
LEU A  96
MET A 170
THR A 167
 None
 1.10A 6nmfN-3bq8A:
undetectable
6nmfW-3bq8A:
undetectable		 6nmfN-3bq8A:
14.63
6nmfW-3bq8A:
16.78