SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bqu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC2_0
(ACTINOMYCIN D)		 3bqu 3H6 FAB HEAVY CHAIN
(Mus
musculus) 		4 / 4 THR D 126
PRO D 158
THR D 125
PRO D 127
 None
 1.35A 1dsdC-3bquD:
undetectable		 1dsdC-3bquD:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC8_0
(ACTINOMYCIN D)		 3bqu 3H6 FAB HEAVY CHAIN
(Mus
musculus) 		4 / 4 THR D 126
PRO D 158
THR D 125
PRO D 127
 None
 1.35A 1dsdC-3bquD:
undetectable		 1dsdC-3bquD:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3bqu 3H6 FAB HEAVY CHAIN
(Mus
musculus) 		5 / 12 VAL D 174
VAL D 192
SER D 190
ASN D 207
ASN D 166
 None
 1.42A 2y03A-3bquD:
undetectable		 2y03A-3bquD:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 3bqu 3H6 FAB HEAVY CHAIN
(Mus
musculus) 		5 / 12 VAL D 174
VAL D 192
SER D 190
ASN D 207
ASN D 166
 None
 1.39A 3nyaA-3bquD:
undetectable		 3nyaA-3bquD:
18.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M7K_H_ACTH302_0
(10H10 HEAVY CHAIN)		 3bqu 3H6 FAB HEAVY CHAIN
(Mus
musculus) 		4 / 5 VAL D   2
TYR D  27
ARG D  98
TYR D 111
 None
None
SO4  D 225 (-3.0A)
None
 0.31A 4m7kH-3bquD:
27.3		 4m7kH-3bquD:
62.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3bqu 3H6 FAB HEAVY CHAIN
(Mus
musculus) 		5 / 12 LEU D 170
VAL D 192
ILE D 221
LEU D 149
VAL D 217
 None
 1.07A 4y0qA-3bquD:
undetectable		 4y0qA-3bquD:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 3bqu 3H6 FAB HEAVY CHAIN
(Mus
musculus) 		5 / 12 ALA D  16
PHE D 157
TYR D 156
LEU D 117
THR D  87
 None
 1.16A 5tl8A-3bquD:
undetectable		 5tl8A-3bquD:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA606_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3bqu 3H6 FAB HEAVY CHAIN
(Mus
musculus) 		4 / 5 GLU D 159
PHE D 157
HIS D 210
THR D 119
 None
 1.11A 6b58A-3bquD:
undetectable		 6b58A-3bquD:
16.75