SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bqy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 3bqy PUTATIVE TETR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 4 ALA A 145
VAL A 129
PHE A 137
THR A  90
 None
 1.42A 2pkkA-3bqyA:
undetectable		 2pkkA-3bqyA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 3bqy PUTATIVE TETR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 5 ARG A  17
MET A  66
THR A  64
LEU A  63
 None
 1.43A 3ag1J-3bqyA:
undetectable		 3ag1J-3bqyA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3bqy PUTATIVE TETR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 5 GLN A  60
THR A 114
HIS A 104
LEU A  28
 None
 1.34A 3ce6A-3bqyA:
undetectable		 3ce6A-3bqyA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3bqy PUTATIVE TETR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 5 GLN A  60
THR A 114
HIS A 104
LEU A  28
 None
 1.35A 3ce6C-3bqyA:
undetectable		 3ce6C-3bqyA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3bqy PUTATIVE TETR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 8 LEU A 177
THR A 176
GLY A 168
ALA A 162
 None
 0.85A 3jusB-3bqyA:
undetectable		 3jusB-3bqyA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 3bqy PUTATIVE TETR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 7 LEU A  36
THR A  20
ALA A  24
LEU A  28
 None
 0.96A 4d7bA-3bqyA:
undetectable		 4d7bA-3bqyA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 3bqy PUTATIVE TETR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 LEU A 101
VAL A 154
ALA A 112
GLU A  68
ALA A  67
 None
 1.01A 4fiaA-3bqyA:
undetectable		 4fiaA-3bqyA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 3bqy PUTATIVE TETR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 LEU A 101
VAL A 154
ALA A 112
GLU A  68
ALA A  67
 None
 1.01A 4fiaA-3bqyA:
undetectable		 4fiaA-3bqyA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 3bqy PUTATIVE TETR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 PHE A 124
VAL A 129
PHE A 111
THR A 157
GLY A 155
 None
 1.20A 4hvcA-3bqyA:
undetectable		 4hvcA-3bqyA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 3bqy PUTATIVE TETR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 PHE A 124
VAL A 129
PHE A 111
THR A 157
GLY A 155
 None
 1.23A 4hvcB-3bqyA:
undetectable		 4hvcB-3bqyA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 3bqy PUTATIVE TETR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 8 LEU A  36
THR A  20
ALA A  24
LEU A  28
 None
 0.83A 4iizB-3bqyA:
undetectable		 4iizB-3bqyA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 3bqy PUTATIVE TETR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 PHE A 124
VAL A 129
PHE A 111
THR A 157
GLY A 155
 None
 1.25A 4olfA-3bqyA:
undetectable		 4olfA-3bqyA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3bqy PUTATIVE TETR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 5 ARG A  17
MET A  66
THR A  64
LEU A  63
 None
 1.30A 5x1bW-3bqyA:
undetectable		 5x1bW-3bqyA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 3bqy PUTATIVE TETR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 PHE A 124
VAL A 129
PHE A 111
THR A 157
GLY A 155
 None
 1.32A 5xioA-3bqyA:
undetectable		 5xioA-3bqyA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 3bqy PUTATIVE TETR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 8 GLY A 155
ASN A 151
SER A 148
PHE A 152
 None
 0.77A 5xu8A-3bqyA:
undetectable		 5xu8A-3bqyA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		 3bqy PUTATIVE TETR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 11 ASP A 106
THR A 157
GLY A 169
ASP A 173
GLU A 174
 None
 1.14A 6mb5A-3bqyA:
undetectable		 6mb5A-3bqyA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3bqy PUTATIVE TETR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 5 ARG A  17
MET A  66
THR A  64
LEU A  63
 None
 1.31A 6nknJ-3bqyA:
undetectable		 6nknJ-3bqyA:
13.88