SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3brc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3brc CONSERVED PROTEIN OF
UNKNOWN FUNCTION
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 LEU A  96
MET A 145
THR A 146
LEU A 149
 None
 1.01A 1v54A-3brcA:
undetectable
1v54J-3brcA:
undetectable		 1v54A-3brcA:
15.00
1v54J-3brcA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3brc CONSERVED PROTEIN OF
UNKNOWN FUNCTION
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 LEU A  96
MET A 145
THR A 146
LEU A 149
 None
 1.00A 2dyrA-3brcA:
undetectable
2dyrJ-3brcA:
undetectable		 2dyrA-3brcA:
15.00
2dyrJ-3brcA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3brc CONSERVED PROTEIN OF
UNKNOWN FUNCTION
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 LEU A  96
MET A 145
THR A 146
LEU A 149
 None
 1.00A 2dysA-3brcA:
undetectable
2dysJ-3brcA:
undetectable		 2dysA-3brcA:
15.00
2dysJ-3brcA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3brc CONSERVED PROTEIN OF
UNKNOWN FUNCTION
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 LEU A  96
MET A 145
THR A 146
LEU A 149
 None
 0.97A 2dysN-3brcA:
undetectable
2dysW-3brcA:
undetectable		 2dysN-3brcA:
15.00
2dysW-3brcA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3brc CONSERVED PROTEIN OF
UNKNOWN FUNCTION
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 LEU A  96
MET A 145
THR A 146
LEU A 149
 None
 1.03A 2eijA-3brcA:
undetectable
2eijJ-3brcA:
undetectable		 2eijA-3brcA:
15.00
2eijJ-3brcA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3brc CONSERVED PROTEIN OF
UNKNOWN FUNCTION
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 LEU A  96
MET A 145
THR A 146
LEU A 149
 None
 1.02A 2eilA-3brcA:
undetectable
2eilJ-3brcA:
undetectable		 2eilA-3brcA:
15.00
2eilJ-3brcA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3brc CONSERVED PROTEIN OF
UNKNOWN FUNCTION
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 LEU A  96
MET A 145
THR A 146
LEU A 149
 None
 1.02A 2zxwA-3brcA:
undetectable
2zxwJ-3brcA:
undetectable		 2zxwA-3brcA:
15.00
2zxwJ-3brcA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3brc CONSERVED PROTEIN OF
UNKNOWN FUNCTION
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 LEU A  96
MET A 145
THR A 146
LEU A 149
 None
 1.03A 3abmA-3brcA:
undetectable
3abmJ-3brcA:
undetectable		 3abmA-3brcA:
15.00
3abmJ-3brcA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3brc CONSERVED PROTEIN OF
UNKNOWN FUNCTION
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 LEU A  96
MET A 145
THR A 146
LEU A 149
 None
 1.02A 3asnA-3brcA:
undetectable
3asnJ-3brcA:
undetectable		 3asnA-3brcA:
15.00
3asnJ-3brcA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3brc CONSERVED PROTEIN OF
UNKNOWN FUNCTION
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 LEU A  96
MET A 145
THR A 146
LEU A 149
 None
 1.03A 3asoA-3brcA:
undetectable
3asoJ-3brcA:
undetectable		 3asoA-3brcA:
15.00
3asoJ-3brcA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 3brc CONSERVED PROTEIN OF
UNKNOWN FUNCTION
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A  96
SER A  35
ILE A  98
PHE A 154
LEU A 149
 None
 1.00A 3vw1B-3brcA:
undetectable		 3vw1B-3brcA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3brc CONSERVED PROTEIN OF
UNKNOWN FUNCTION
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 ARG A  57
ARG A 142
ASP A  50
 None
 0.87A 3wipG-3brcA:
undetectable
3wipH-3brcA:
undetectable		 3wipG-3brcA:
17.83
3wipH-3brcA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3brc CONSERVED PROTEIN OF
UNKNOWN FUNCTION
(Methanothermobac
ter
thermautotrophic
us) 		4 / 5 ARG A 142
MET A 145
THR A 146
LEU A 149
 None
 1.21A 5x1bW-3brcA:
undetectable		 5x1bW-3brcA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3brc CONSERVED PROTEIN OF
UNKNOWN FUNCTION
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 LEU A  96
MET A 145
THR A 146
LEU A 149
 None
 0.94A 5x1fA-3brcA:
undetectable
5x1fJ-3brcA:
undetectable		 5x1fA-3brcA:
15.00
5x1fJ-3brcA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3brc CONSERVED PROTEIN OF
UNKNOWN FUNCTION
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 LEU A  96
MET A 145
THR A 146
LEU A 149
 None
 0.92A 5xdqN-3brcA:
undetectable
5xdqW-3brcA:
undetectable		 5xdqN-3brcA:
15.00
5xdqW-3brcA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 3brc CONSERVED PROTEIN OF
UNKNOWN FUNCTION
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 ASP A   4
LEU A   5
ARG A  18
 None
 0.73A 7dfrA-3brcA:
undetectable		 7dfrA-3brcA:
20.24