SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bre'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 3bre PROBABLE
TWO-COMPONENT
RESPONSE REGULATOR
(Pseudomonas
aeruginosa) 		4 / 8 ARG A 182
GLY A 251
ARG A 249
THR A 177
 None
 0.92A 2f9wA-3breA:
undetectable
2f9wB-3breA:
undetectable		 2f9wA-3breA:
22.93
2f9wB-3breA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 3bre PROBABLE
TWO-COMPONENT
RESPONSE REGULATOR
(Pseudomonas
aeruginosa) 		4 / 8 VAL A  58
ASN A  60
ALA A  84
GLN A  69
 None
 1.09A 2ij7C-3breA:
undetectable		 2ij7C-3breA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3bre PROBABLE
TWO-COMPONENT
RESPONSE REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 303
LEU A 206
MET A 207
 None
 0.86A 2itzA-3breA:
undetectable		 2itzA-3breA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3bre PROBABLE
TWO-COMPONENT
RESPONSE REGULATOR
(Pseudomonas
aeruginosa) 		6 / 12 ASP A 174
LEU A 179
GLY A 252
LEU A 176
ILE A 208
ASP A 209
 None
 1.39A 2nxeA-3breA:
undetectable		 2nxeA-3breA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 3bre PROBABLE
TWO-COMPONENT
RESPONSE REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 276
ILE A 298
THR A 302
 None
 0.71A 3ia4D-3breA:
undetectable		 3ia4D-3breA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3bre PROBABLE
TWO-COMPONENT
RESPONSE REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 GLU A 253
ASN A 217
ASP A 226
ASP A 174
GLY A 251
 None
 1.14A 4djeA-3breA:
2.7		 4djeA-3breA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3bre PROBABLE
TWO-COMPONENT
RESPONSE REGULATOR
(Pseudomonas
aeruginosa) 		4 / 5 VAL A  98
LEU A  99
SER A 100
MET A  73
 None
 1.31A 4e1gA-3breA:
undetectable		 4e1gA-3breA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_2
(ASPARTYL PROTEASE)		 3bre PROBABLE
TWO-COMPONENT
RESPONSE REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 208
ILE A 236
GLY A 239
VAL A 300
ILE A 298
 None
 0.59A 4q1xB-3breA:
undetectable		 4q1xB-3breA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 3bre PROBABLE
TWO-COMPONENT
RESPONSE REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 208
ILE A 236
GLY A 239
VAL A 300
ILE A 298
 None
 0.73A 4q1yB-3breA:
undetectable		 4q1yB-3breA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 3bre PROBABLE
TWO-COMPONENT
RESPONSE REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 185
ILE A 316
ALA A 256
SER A 301
LEU A 315
 None
 1.35A 4qztC-3breA:
undetectable		 4qztC-3breA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3bre PROBABLE
TWO-COMPONENT
RESPONSE REGULATOR
(Pseudomonas
aeruginosa) 		4 / 4 GLY A 299
LEU A 189
PHE A 312
ILE A 316
 None
 0.86A 4xv2A-3breA:
undetectable		 4xv2A-3breA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3bre PROBABLE
TWO-COMPONENT
RESPONSE REGULATOR
(Pseudomonas
aeruginosa) 		4 / 5 SER A 180
ALA A 248
HIS A 184
LEU A 246
 None
 1.37A 5dzkb-3breA:
undetectable
5dzkp-3breA:
undetectable		 5dzkb-3breA:
19.83
5dzkp-3breA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3bre PROBABLE
TWO-COMPONENT
RESPONSE REGULATOR
(Pseudomonas
aeruginosa) 		4 / 5 SER A 180
ALA A 248
HIS A 184
LEU A 246
 None
 1.44A 5dzkc-3breA:
undetectable
5dzkq-3breA:
undetectable		 5dzkc-3breA:
19.83
5dzkq-3breA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3bre PROBABLE
TWO-COMPONENT
RESPONSE REGULATOR
(Pseudomonas
aeruginosa) 		4 / 5 SER A 180
ALA A 248
HIS A 184
LEU A 246
 None
 1.35A 5dzkf-3breA:
undetectable
5dzkt-3breA:
undetectable		 5dzkf-3breA:
19.83
5dzkt-3breA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 3bre PROBABLE
TWO-COMPONENT
RESPONSE REGULATOR
(Pseudomonas
aeruginosa) 		5 / 7 VAL A  34
LEU A 129
GLU A  32
ALA A  33
LEU A  23
 None
 1.22A 5jq7A-3breA:
undetectable		 5jq7A-3breA:
20.60