SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3brn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 3brn LIPOCALIN
(Argas
monolakensis) 		4 / 5 TYR A 152
PRO A 155
LEU A 156
ARG A  30
 None
 1.30A 1i2wA-3brnA:
undetectable		 1i2wA-3brnA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFT_A_HSMA176_1
(PROTEIN
(FEMALE-SPECIFIC
HISTAMINE BINDING
PROTEIN 2))		 3brn LIPOCALIN
(Argas
monolakensis) 		5 / 9 SER A  18
TYR A  27
VAL A  43
ASP A 106
TRP A 118
 SRO  A 158 (-3.6A)
SRO  A 158 (-3.5A)
SRO  A 158 ( 4.6A)
SRO  A 158 (-3.2A)
SRO  A 158 (-3.3A)
 0.40A 1qftA-3brnA:
16.1		 1qftA-3brnA:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFT_B_HSMB176_1
(PROTEIN
(FEMALE-SPECIFIC
HISTAMINE BINDING
PROTEIN 2))		 3brn LIPOCALIN
(Argas
monolakensis) 		5 / 9 SER A  18
TYR A  27
VAL A  43
ASP A 106
TRP A 118
 SRO  A 158 (-3.6A)
SRO  A 158 (-3.5A)
SRO  A 158 ( 4.6A)
SRO  A 158 (-3.2A)
SRO  A 158 (-3.3A)
 0.33A 1qftB-3brnA:
8.5		 1qftB-3brnA:
27.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 3brn LIPOCALIN
(Argas
monolakensis) 		5 / 6 SER A  18
TYR A  27
VAL A  43
ASP A 106
TRP A 118
 SRO  A 158 (-3.6A)
SRO  A 158 (-3.5A)
SRO  A 158 ( 4.6A)
SRO  A 158 (-3.2A)
SRO  A 158 (-3.3A)
 0.25A 2x45A-3brnA:
22.7		 2x45A-3brnA:
36.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 3brn LIPOCALIN
(Argas
monolakensis) 		6 / 7 SER A  18
TYR A  27
VAL A  43
ILE A  82
ASP A 106
TRP A 118
 SRO  A 158 (-3.6A)
SRO  A 158 (-3.5A)
SRO  A 158 ( 4.6A)
SRO  A 158 (-4.4A)
SRO  A 158 (-3.2A)
SRO  A 158 (-3.3A)
 0.33A 2x45B-3brnA:
22.5		 2x45B-3brnA:
36.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 3brn LIPOCALIN
(Argas
monolakensis) 		6 / 7 SER A  18
TYR A  27
VAL A  43
ILE A  82
ASP A 106
TRP A 118
 SRO  A 158 (-3.6A)
SRO  A 158 (-3.5A)
SRO  A 158 ( 4.6A)
SRO  A 158 (-4.4A)
SRO  A 158 (-3.2A)
SRO  A 158 (-3.3A)
 0.31A 2x45C-3brnA:
22.4		 2x45C-3brnA:
36.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BU1_A_HSMA301_1
(LIPOCALIN)		 3brn LIPOCALIN
(Argas
monolakensis) 		6 / 7 SER A  18
TYR A  27
VAL A  43
ILE A  82
ASP A 106
TRP A 118
 SRO  A 158 (-3.6A)
SRO  A 158 (-3.5A)
SRO  A 158 ( 4.6A)
SRO  A 158 (-4.4A)
SRO  A 158 (-3.2A)
SRO  A 158 (-3.3A)
 0.48A 3bu1A-3brnA:
22.3		 3bu1A-3brnA:
42.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 3brn LIPOCALIN
(Argas
monolakensis) 		5 / 9 TYR A  27
VAL A  45
GLY A  26
ASN A  24
GLY A  23
 SRO  A 158 (-3.5A)
None
None
None
None
 1.44A 3kmoA-3brnA:
undetectable		 3kmoA-3brnA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 3brn LIPOCALIN
(Argas
monolakensis) 		5 / 12 ASP A 106
SER A 100
SER A  18
TYR A  27
VAL A  45
 SRO  A 158 (-3.2A)
None
SRO  A 158 (-3.6A)
SRO  A 158 (-3.5A)
None
 1.46A 3mbhC-3brnA:
undetectable		 3mbhC-3brnA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_E_PXLE400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 3brn LIPOCALIN
(Argas
monolakensis) 		5 / 12 ASP A 106
SER A 100
SER A  18
TYR A  27
VAL A  45
 SRO  A 158 (-3.2A)
None
SRO  A 158 (-3.6A)
SRO  A 158 (-3.5A)
None
 1.48A 3mbhE-3brnA:
undetectable		 3mbhE-3brnA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3brn LIPOCALIN
(Argas
monolakensis) 		4 / 4 GLY A 113
GLY A 110
THR A  96
LEU A  98
 None
 0.84A 3si7C-3brnA:
undetectable
3si7D-3brnA:
undetectable		 3si7C-3brnA:
18.18
3si7D-3brnA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3brn LIPOCALIN
(Argas
monolakensis) 		4 / 7 THR A  85
LEU A  50
ASN A  78
GLN A  14
 None
 0.88A 4ib4A-3brnA:
undetectable		 4ib4A-3brnA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3brn LIPOCALIN
(Argas
monolakensis) 		5 / 12 GLY A  21
PRO A  22
GLY A  23
ILE A  82
THR A  95
 None
None
None
SRO  A 158 (-4.4A)
SRO  A 158 ( 4.1A)
 1.13A 4n48A-3brnA:
undetectable		 4n48A-3brnA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3brn LIPOCALIN
(Argas
monolakensis) 		4 / 6 THR A  85
LEU A  50
ASN A  78
GLN A  14
 None
 0.91A 4nc3A-3brnA:
undetectable		 4nc3A-3brnA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3brn LIPOCALIN
(Argas
monolakensis) 		5 / 11 SER A  18
THR A  96
THR A  95
GLY A  79
ALA A  15
 SRO  A 158 (-3.6A)
None
SRO  A 158 ( 4.1A)
None
None
 1.39A 4qwuV-3brnA:
undetectable
4qwub-3brnA:
undetectable		 4qwuV-3brnA:
23.77
4qwub-3brnA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 3brn LIPOCALIN
(Argas
monolakensis) 		5 / 9 ALA A  15
ASP A  80
GLY A  53
VAL A  84
ILE A  82
 None
None
None
None
SRO  A 158 (-4.4A)
 1.17A 5kr0A-3brnA:
undetectable		 5kr0A-3brnA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 3brn LIPOCALIN
(Argas
monolakensis) 		3 / 3 THR A  76
PRO A 111
ARG A 109
 None
 0.65A 5nd7B-3brnA:
undetectable		 5nd7B-3brnA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 3brn LIPOCALIN
(Argas
monolakensis) 		4 / 7 THR A  85
LEU A  50
ASN A  78
GLN A  14
 None
 1.04A 5tudA-3brnA:
undetectable		 5tudA-3brnA:
15.35