SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3brq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3brq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ASCG
(Escherichia
coli) 		4 / 7 ALA A  61
ILE A  94
ILE A  81
GLU A  64
 None
 0.97A 1oniD-3brqA:
undetectable
1oniF-3brqA:
undetectable		 1oniD-3brqA:
19.86
1oniF-3brqA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 3brq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ASCG
(Escherichia
coli) 		4 / 8 TYR A  33
VAL A  24
ARG A 155
HIS A 121
 FRU  A 701 ( 4.0A)
None
FRU  A 701 ( 4.6A)
None
 1.16A 1s3zA-3brqA:
undetectable
1s3zB-3brqA:
undetectable		 1s3zA-3brqA:
19.67
1s3zB-3brqA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3brq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ASCG
(Escherichia
coli) 		4 / 5 LEU A  20
GLY A 270
PRO A 101
ALA A  78
 None
 0.80A 2aohA-3brqA:
undetectable		 2aohA-3brqA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 3brq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ASCG
(Escherichia
coli) 		4 / 6 ASP A 235
THR A 254
GLU A  36
GLU A 255
 None
 1.31A 2dttB-3brqA:
undetectable
2dttC-3brqA:
undetectable		 2dttB-3brqA:
16.89
2dttC-3brqA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 3brq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ASCG
(Escherichia
coli) 		5 / 12 ILE A  91
LEU A  86
GLU A  62
ILE A  94
ILE A 102
 None
 0.86A 2gj5A-3brqA:
undetectable		 2gj5A-3brqA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 3brq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ASCG
(Escherichia
coli) 		4 / 5 LEU A  86
ILE A  94
ILE A  68
ALA A  67
 None
 0.68A 2i2zA-3brqA:
undetectable		 2i2zA-3brqA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 3brq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ASCG
(Escherichia
coli) 		4 / 8 LEU A  86
ASP A  93
ASP A  89
ARG A  65
 None
 1.04A 2j2pA-3brqA:
undetectable
2j2pB-3brqA:
undetectable		 2j2pA-3brqA:
19.67
2j2pB-3brqA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 3brq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ASCG
(Escherichia
coli) 		3 / 3 MET A 256
GLU A  36
ASP A 207
 None
 1.09A 3a25A-3brqA:
undetectable		 3a25A-3brqA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3brq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ASCG
(Escherichia
coli) 		4 / 7 PHE A 199
VAL A 228
VAL A 230
SER A 247
 None
 0.91A 3hs6B-3brqA:
undetectable		 3hs6B-3brqA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 3brq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ASCG
(Escherichia
coli) 		5 / 12 ILE A 133
ALA A 135
LEU A 289
LEU A 283
ILE A 140
 None
 1.02A 3tq9A-3brqA:
undetectable		 3tq9A-3brqA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3brq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ASCG
(Escherichia
coli) 		5 / 12 ILE A  91
LEU A  86
GLU A  62
ILE A  94
ILE A 102
 None
 0.86A 4y0rA-3brqA:
undetectable		 4y0rA-3brqA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 3brq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ASCG
(Escherichia
coli) 		4 / 5 HIS A 218
VAL A 189
GLY A 212
ALA A 186
 None
 0.97A 5hwaA-3brqA:
undetectable		 5hwaA-3brqA:
21.67