SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3brs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 3brs PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Lachnoclostridiu
m
phytofermentans) 		4 / 6 VAL A 254
GLY A 253
ALA A  29
LEU A  40
 None
 0.57A 1e7bB-3brsA:
undetectable		 1e7bB-3brsA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3brs PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Lachnoclostridiu
m
phytofermentans) 		5 / 12 TYR A 200
ALA A 110
ILE A 249
ALA A  73
PHE A  21
 None
 1.33A 1udtA-3brsA:
undetectable		 1udtA-3brsA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3brs PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Lachnoclostridiu
m
phytofermentans) 		4 / 8 SER A 143
GLY A 196
ASN A 198
ALA A 205
 None
 0.84A 3aodA-3brsA:
undetectable		 3aodA-3brsA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 3brs PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Lachnoclostridiu
m
phytofermentans) 		5 / 11 LEU A 153
LYS A 125
ASN A 126
ALA A 240
VAL A 242
 None
 1.19A 3e22B-3brsA:
undetectable		 3e22B-3brsA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 3brs PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Lachnoclostridiu
m
phytofermentans) 		5 / 11 LEU A 153
LYS A 125
ASN A 126
ALA A 240
VAL A 242
 None
 1.20A 3e22D-3brsA:
2.9		 3e22D-3brsA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3brs PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Lachnoclostridiu
m
phytofermentans) 		5 / 10 ALA A 205
SER A 192
LEU A 127
VAL A 221
THR A 181
 None
 1.49A 4eilB-3brsA:
3.7		 4eilB-3brsA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3brs PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Lachnoclostridiu
m
phytofermentans) 		5 / 12 ALA A 205
SER A 192
LEU A 127
VAL A 221
THR A 181
 None
 1.41A 4kyaB-3brsA:
2.4		 4kyaB-3brsA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3brs PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Lachnoclostridiu
m
phytofermentans) 		5 / 12 ALA A 205
SER A 192
LEU A 127
VAL A 221
THR A 181
 None
 1.42A 4kyaD-3brsA:
undetectable		 4kyaD-3brsA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3brs PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Lachnoclostridiu
m
phytofermentans) 		5 / 12 ALA A 205
SER A 192
LEU A 127
VAL A 221
THR A 181
 None
 1.39A 4kyaF-3brsA:
undetectable		 4kyaF-3brsA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3brs PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Lachnoclostridiu
m
phytofermentans) 		5 / 12 ALA A 205
SER A 192
LEU A 127
VAL A 221
THR A 181
 None
 1.42A 4kyaH-3brsA:
2.9		 4kyaH-3brsA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3brs PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Lachnoclostridiu
m
phytofermentans) 		5 / 10 ALA A  73
ILE A  11
ALA A  82
ALA A  83
ILE A  58
 None
 1.03A 4lbgA-3brsA:
5.3		 4lbgA-3brsA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3brs PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Lachnoclostridiu
m
phytofermentans) 		5 / 11 GLY A 204
THR A 203
ALA A 202
ASP A 224
CYH A 222
 None
 1.46A 4qvnH-3brsA:
undetectable
4qvnI-3brsA:
undetectable		 4qvnH-3brsA:
20.32
4qvnI-3brsA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3brs PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Lachnoclostridiu
m
phytofermentans) 		5 / 11 THR A 181
GLY A 204
THR A 203
ALA A 202
ASP A 224
 None
 1.36A 4qvnH-3brsA:
undetectable
4qvnI-3brsA:
undetectable		 4qvnH-3brsA:
20.32
4qvnI-3brsA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3brs PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Lachnoclostridiu
m
phytofermentans) 		5 / 10 GLY A 204
THR A 203
ALA A 202
ASP A 224
CYH A 222
 None
 1.46A 4qvnV-3brsA:
undetectable
4qvnW-3brsA:
undetectable		 4qvnV-3brsA:
20.32
4qvnW-3brsA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3brs PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Lachnoclostridiu
m
phytofermentans) 		5 / 10 THR A 181
GLY A 204
THR A 203
ALA A 202
ASP A 224
 None
 1.35A 4qvnV-3brsA:
undetectable
4qvnW-3brsA:
undetectable		 4qvnV-3brsA:
20.32
4qvnW-3brsA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3brs PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Lachnoclostridiu
m
phytofermentans) 		5 / 11 GLY A 204
THR A 203
ALA A 202
ASP A 224
CYH A 222
 None
 1.46A 4qvqH-3brsA:
undetectable
4qvqI-3brsA:
undetectable		 4qvqH-3brsA:
20.32
4qvqI-3brsA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3brs PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Lachnoclostridiu
m
phytofermentans) 		5 / 11 THR A 181
GLY A 204
THR A 203
ALA A 202
ASP A 224
 None
 1.38A 4qvqH-3brsA:
undetectable
4qvqI-3brsA:
undetectable		 4qvqH-3brsA:
20.32
4qvqI-3brsA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3brs PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Lachnoclostridiu
m
phytofermentans) 		5 / 11 GLY A 204
THR A 203
ALA A 202
ASP A 224
CYH A 222
 None
 1.46A 4qvqV-3brsA:
undetectable
4qvqW-3brsA:
undetectable		 4qvqV-3brsA:
20.32
4qvqW-3brsA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3brs PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Lachnoclostridiu
m
phytofermentans) 		5 / 11 THR A 181
GLY A 204
THR A 203
ALA A 202
ASP A 224
 None
 1.37A 4qvqV-3brsA:
undetectable
4qvqW-3brsA:
undetectable		 4qvqV-3brsA:
20.32
4qvqW-3brsA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3brs PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Lachnoclostridiu
m
phytofermentans) 		5 / 11 GLY A 204
THR A 203
ALA A 202
ASP A 224
CYH A 222
 None
 1.46A 4qwuH-3brsA:
undetectable
4qwuI-3brsA:
undetectable		 4qwuH-3brsA:
20.32
4qwuI-3brsA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3brs PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Lachnoclostridiu
m
phytofermentans) 		5 / 11 THR A 181
GLY A 204
THR A 203
ALA A 202
ASP A 224
 None
 1.33A 4qwuH-3brsA:
undetectable
4qwuI-3brsA:
undetectable		 4qwuH-3brsA:
20.32
4qwuI-3brsA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3brs PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Lachnoclostridiu
m
phytofermentans) 		5 / 11 GLY A 204
THR A 203
ALA A 202
ASP A 224
CYH A 222
 None
 1.46A 4qwuV-3brsA:
undetectable
4qwuW-3brsA:
undetectable		 4qwuV-3brsA:
20.32
4qwuW-3brsA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3brs PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Lachnoclostridiu
m
phytofermentans) 		5 / 11 THR A 181
GLY A 204
THR A 203
ALA A 202
ASP A 224
 None
 1.32A 4qwuV-3brsA:
undetectable
4qwuW-3brsA:
undetectable		 4qwuV-3brsA:
20.32
4qwuW-3brsA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3brs PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Lachnoclostridiu
m
phytofermentans) 		5 / 9 GLY A 117
VAL A 221
GLY A 156
LEU A 157
ILE A 191
 None
 0.96A 5vkqC-3brsA:
undetectable
5vkqD-3brsA:
undetectable		 5vkqC-3brsA:
9.87
5vkqD-3brsA:
9.87