SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bru'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 3bru REGULATORY PROTEIN,
TETR FAMILY
(Rhodobacter
sphaeroides) 		5 / 11 LEU A 159
HIS A 173
LEU A 169
HIS A 212
GLY A 210
 None
 1.31A 1cmaA-3bruA:
undetectable
1cmaB-3bruA:
1.2		 1cmaA-3bruA:
24.86
1cmaB-3bruA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_B_SAMB400_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 3bru REGULATORY PROTEIN,
TETR FAMILY
(Rhodobacter
sphaeroides) 		5 / 9 LEU A 159
HIS A 173
LEU A 169
HIS A 212
GLY A 210
 None
 1.30A 1mjlA-3bruA:
undetectable
1mjlB-3bruA:
1.3		 1mjlA-3bruA:
25.42
1mjlB-3bruA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 3bru REGULATORY PROTEIN,
TETR FAMILY
(Rhodobacter
sphaeroides) 		5 / 11 LEU A 159
HIS A 173
LEU A 169
HIS A 212
GLY A 210
 None
 1.32A 1mjqA-3bruA:
1.2
1mjqB-3bruA:
undetectable		 1mjqA-3bruA:
25.42
1mjqB-3bruA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 3bru REGULATORY PROTEIN,
TETR FAMILY
(Rhodobacter
sphaeroides) 		5 / 11 HIS A 212
GLY A 210
LEU A 159
HIS A 173
LEU A 169
 None
 1.41A 1mjqA-3bruA:
1.2
1mjqB-3bruA:
undetectable		 1mjqA-3bruA:
25.42
1mjqB-3bruA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3bru REGULATORY PROTEIN,
TETR FAMILY
(Rhodobacter
sphaeroides) 		5 / 12 GLY A 188
VAL A 127
ARG A 118
ALA A 193
PHE A 121
 None
 0.84A 3sugA-3bruA:
undetectable		 3sugA-3bruA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 3bru REGULATORY PROTEIN,
TETR FAMILY
(Rhodobacter
sphaeroides) 		4 / 8 GLY A 147
GLN A 153
LEU A 149
THR A 151
 None
 0.91A 5sxqA-3bruA:
2.3		 5sxqA-3bruA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 3bru REGULATORY PROTEIN,
TETR FAMILY
(Rhodobacter
sphaeroides) 		4 / 8 GLY A 147
GLN A 153
LEU A 149
THR A 151
 None
 0.90A 5sxqB-3bruA:
3.1		 5sxqB-3bruA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 3bru REGULATORY PROTEIN,
TETR FAMILY
(Rhodobacter
sphaeroides) 		4 / 8 GLY A 147
GLN A 153
LEU A 149
THR A 151
 None
 0.88A 5sxtA-3bruA:
undetectable		 5sxtA-3bruA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 3bru REGULATORY PROTEIN,
TETR FAMILY
(Rhodobacter
sphaeroides) 		4 / 8 GLY A 147
GLN A 153
LEU A 149
THR A 151
 None
 0.87A 5sxtB-3bruA:
2.1		 5sxtB-3bruA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 3bru REGULATORY PROTEIN,
TETR FAMILY
(Rhodobacter
sphaeroides) 		4 / 8 GLY A 147
GLN A 153
LEU A 149
THR A 151
 None
 0.87A 5syjA-3bruA:
undetectable		 5syjA-3bruA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 3bru REGULATORY PROTEIN,
TETR FAMILY
(Rhodobacter
sphaeroides) 		4 / 8 GLY A 147
GLN A 153
LEU A 149
THR A 151
 None
 0.82A 5syjB-3bruA:
1.5		 5syjB-3bruA:
15.91