SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3brx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 3brx ANNEXIN
(Gossypium
hirsutum) 		4 / 6 LEU A 225
VAL A 241
LYS A 242
ILE A 184
 None
None
PO4  A 322 ( 4.6A)
None
 0.84A 2piwA-3brxA:
undetectable		 2piwA-3brxA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)		 3brx ANNEXIN
(Gossypium
hirsutum) 		4 / 5 PRO A 247
ILE A 284
ARG A 276
ASP A 280
 None
 1.26A 2rhmB-3brxA:
undetectable		 2rhmB-3brxA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 3brx ANNEXIN
(Gossypium
hirsutum) 		3 / 3 ARG A 271
LEU A  96
THR A 105
 None
 0.76A 3oxcA-3brxA:
undetectable		 3oxcA-3brxA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 3brx ANNEXIN
(Gossypium
hirsutum) 		5 / 11 LEU A  66
THR A  34
ASN A  35
GLY A  37
ASP A  41
 None
CA  A 327 ( 4.9A)
None
None
None
 1.45A 3sfuC-3brxA:
undetectable		 3sfuC-3brxA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 3brx ANNEXIN
(Gossypium
hirsutum) 		4 / 5 ILE A 259
ILE A 284
TYR A 288
GLU A 287
 None
None
None
PO4  A 322 ( 4.8A)
 1.26A 4a99D-3brxA:
undetectable		 4a99D-3brxA:
23.79