SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3brz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 3brz TODX
(Pseudomonas
putida) 		4 / 8 GLY A 152
ASN A  33
GLY A 224
VAL A 234
 None
 0.75A 1dbbH-3brzA:
undetectable
1dbbL-3brzA:
undetectable		 1dbbH-3brzA:
20.63
1dbbL-3brzA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_2
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION
CHIMERA OF IG
GAMMA-1 CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 3brz TODX
(Pseudomonas
putida) 		4 / 5 TYR A 330
GLU A 276
PRO A 327
ASP A 309
 None
 1.44A 1i7zB-3brzA:
undetectable		 1i7zB-3brzA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 3brz TODX
(Pseudomonas
putida) 		5 / 11 ALA A 252
PHE A 315
LEU A 190
ALA A 200
HIS A 201
 None
None
C8E  A 501 ( 4.2A)
C8E  A 501 (-3.2A)
None
 1.18A 1mjlA-3brzA:
undetectable
1mjlB-3brzA:
undetectable		 1mjlA-3brzA:
11.85
1mjlB-3brzA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 3brz TODX
(Pseudomonas
putida) 		4 / 7 THR A 226
THR A 150
SER A 142
VAL A  87
 None
 1.07A 1tv8A-3brzA:
undetectable		 1tv8A-3brzA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3brz TODX
(Pseudomonas
putida) 		4 / 5 SER A 280
TYR A   9
SER A 355
ASP A   5
 None
 1.43A 1vidA-3brzA:
undetectable		 1vidA-3brzA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3brz TODX
(Pseudomonas
putida) 		4 / 6 ALA A 237
SER A  21
ILE A 299
ASP A 298
 None
 1.01A 1yc2A-3brzA:
undetectable		 1yc2A-3brzA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 3brz TODX
(Pseudomonas
putida) 		4 / 7 ALA A 237
SER A  21
ILE A 299
ASP A 298
 None
 0.96A 1yc5A-3brzA:
undetectable		 1yc5A-3brzA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 3brz TODX
(Pseudomonas
putida) 		4 / 8 THR A 226
THR A 150
SER A 142
VAL A  87
 None
 1.10A 2fb2A-3brzA:
undetectable		 2fb2A-3brzA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3brz TODX
(Pseudomonas
putida) 		4 / 5 SER A  13
GLY A  17
ASP A 332
ASP A 298
 None
 1.00A 2oxtB-3brzA:
undetectable		 2oxtB-3brzA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 3brz TODX
(Pseudomonas
putida) 		4 / 7 ALA A 279
TYR A 239
TYR A 303
ASP A 306
 None
 1.23A 2pncA-3brzA:
undetectable		 2pncA-3brzA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3brz TODX
(Pseudomonas
putida) 		4 / 5 THR A   1
THR A  55
HIS A 420
LEU A 374
 None
 1.39A 2zj0A-3brzA:
undetectable		 2zj0A-3brzA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3brz TODX
(Pseudomonas
putida) 		4 / 5 THR A   1
THR A  55
HIS A 420
LEU A 374
 None
 1.36A 3ce6A-3brzA:
undetectable		 3ce6A-3brzA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3brz TODX
(Pseudomonas
putida) 		4 / 5 THR A   1
THR A  55
HIS A 420
LEU A 374
 None
 1.38A 3ce6C-3brzA:
undetectable		 3ce6C-3brzA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 3brz TODX
(Pseudomonas
putida) 		5 / 11 ALA A  65
ASN A 128
LEU A 115
LEU A 416
ILE A  57
 None
 1.22A 3jw5A-3brzA:
undetectable		 3jw5A-3brzA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3brz TODX
(Pseudomonas
putida) 		5 / 12 VAL A 187
LEU A 190
LEU A 182
SER A 255
GLY A 320
 C8E  A 501 ( 4.3A)
C8E  A 501 ( 4.2A)
None
None
None
 1.17A 3kk6B-3brzA:
undetectable		 3kk6B-3brzA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 3brz TODX
(Pseudomonas
putida) 		5 / 12 HIS A 377
ALA A  11
GLY A  10
GLU A  47
ASN A 393
 None
 1.07A 3v3oB-3brzA:
undetectable		 3v3oB-3brzA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 3brz TODX
(Pseudomonas
putida) 		4 / 6 PHE A 100
ALA A  28
GLY A  96
VAL A  87
 None
 1.03A 4dubA-3brzA:
undetectable		 4dubA-3brzA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3brz TODX
(Pseudomonas
putida) 		5 / 12 ILE A  57
ALA A  67
LEU A 416
LYS A 365
PRO A 169
 None
 1.39A 4gh8B-3brzA:
undetectable		 4gh8B-3brzA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 3brz TODX
(Pseudomonas
putida) 		4 / 8 GLY A 218
ILE A 139
SER A 154
GLY A 220
 None
 0.71A 5alcL-3brzA:
undetectable		 5alcL-3brzA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 3brz TODX
(Pseudomonas
putida) 		4 / 6 ASP A   5
TRP A 304
TYR A 303
SER A 280
 None
 1.44A 5b6iB-3brzA:
undetectable		 5b6iB-3brzA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3brz TODX
(Pseudomonas
putida) 		4 / 5 SER A 280
TYR A   9
SER A 355
ASP A   5
 None
 1.47A 5fhrA-3brzA:
undetectable		 5fhrA-3brzA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3brz TODX
(Pseudomonas
putida) 		3 / 3 ARG A 329
PRO A 327
ASN A 181
 None
 0.87A 5jwaA-3brzA:
undetectable
5jwaH-3brzA:
undetectable		 5jwaA-3brzA:
20.70
5jwaH-3brzA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 3brz TODX
(Pseudomonas
putida) 		4 / 7 ARG A 376
ALA A 336
ILE A 333
LEU A   6
 None
C8E  A 502 (-3.3A)
None
None
 0.97A 5te8A-3brzA:
undetectable		 5te8A-3brzA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3brz TODX
(Pseudomonas
putida) 		4 / 8 SER A 430
ARG A 391
ASN A 393
GLN A  83
 None
 1.23A 5vunA-3brzA:
undetectable		 5vunA-3brzA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJO_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 3brz TODX
(Pseudomonas
putida) 		5 / 12 GLY A  43
TYR A  24
ASN A  27
ASN A 432
PHE A 433
 None
 1.45A 5yjoA-3brzA:
undetectable		 5yjoA-3brzA:
23.26