SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bs4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3bs4 UNCHARACTERIZED
PROTEIN PH0321
(Pyrococcus
horikoshii) 		5 / 11 THR A 165
SER A 166
PHE A  54
VAL A 153
PHE A  92
 None
 1.35A 1q23G-3bs4A:
undetectable		 1q23G-3bs4A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3bs4 UNCHARACTERIZED
PROTEIN PH0321
(Pyrococcus
horikoshii) 		5 / 11 THR A 165
SER A 166
PHE A  54
VAL A 153
PHE A  92
 None
 1.43A 1q23J-3bs4A:
undetectable		 1q23J-3bs4A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 3bs4 UNCHARACTERIZED
PROTEIN PH0321
(Pyrococcus
horikoshii) 		4 / 7 MET A  53
ALA A 144
ILE A 145
ILE A  63
 None
 0.92A 1upfB-3bs4A:
2.2		 1upfB-3bs4A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 3bs4 UNCHARACTERIZED
PROTEIN PH0321
(Pyrococcus
horikoshii) 		4 / 6 ILE A  22
PRO A 247
LEU A 223
ILE A  36
 None
 0.95A 2q83B-3bs4A:
undetectable		 2q83B-3bs4A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 3bs4 UNCHARACTERIZED
PROTEIN PH0321
(Pyrococcus
horikoshii) 		4 / 8 ARG A  43
ILE A  40
PHE A 185
TYR A  58
 None
 0.63A 2tsrB-3bs4A:
undetectable		 2tsrB-3bs4A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 3bs4 UNCHARACTERIZED
PROTEIN PH0321
(Pyrococcus
horikoshii) 		4 / 6 LEU A  45
SER A   3
ASP A  10
LYS A  46
 None
 1.17A 2vn1B-3bs4A:
undetectable		 2vn1B-3bs4A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3bs4 UNCHARACTERIZED
PROTEIN PH0321
(Pyrococcus
horikoshii) 		4 / 7 ILE A  56
PHE A  38
TYR A  58
GLY A  90
 None
 1.11A 3em0B-3bs4A:
undetectable		 3em0B-3bs4A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 3bs4 UNCHARACTERIZED
PROTEIN PH0321
(Pyrococcus
horikoshii) 		3 / 3 VAL A  86
TYR A 118
ALA A 121
 None
 0.43A 4ybnA-3bs4A:
undetectable		 4ybnA-3bs4A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3bs4 UNCHARACTERIZED
PROTEIN PH0321
(Pyrococcus
horikoshii) 		4 / 8 GLY A  33
GLU A  26
ALA A  29
PHE A 242
 None
 0.89A 5mvsB-3bs4A:
2.7		 5mvsB-3bs4A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 3bs4 UNCHARACTERIZED
PROTEIN PH0321
(Pyrococcus
horikoshii) 		4 / 8 PRO A 247
TYR A  39
ILE A  40
TYR A 240
 None
 0.55A 5mzrE-3bs4A:
undetectable		 5mzrE-3bs4A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3bs4 UNCHARACTERIZED
PROTEIN PH0321
(Pyrococcus
horikoshii) 		4 / 7 ILE A  24
LEU A 208
ARG A  32
LEU A 249
 None
 0.93A 6nmfA-3bs4A:
undetectable
6nmfJ-3bs4A:
undetectable		 6nmfA-3bs4A:
18.10
6nmfJ-3bs4A:
11.92