SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bs8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		4 / 8 SER A 338
TYR A  58
MET A 387
VAL A 392
 None
 1.08A 1fduB-3bs8A:
undetectable		 1fduB-3bs8A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_A_CHCA1001_1
(BILE ACID RECEPTOR)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 12 PHE A 380
ILE A 346
PHE A 424
ILE A 337
TYR A 383
 None
 1.36A 1ot7A-3bs8A:
0.0		 1ot7A-3bs8A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		4 / 5 GLY A 118
PRO A  64
VAL A 269
ILE A 270
 PMP  A 431 (-3.6A)
None
None
None
 1.00A 2aoiA-3bs8A:
undetectable		 2aoiA-3bs8A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 11 LEU A  60
ILE A  66
LEU A 318
PHE A 246
GLY A 245
 None
 1.16A 2bxmA-3bs8A:
undetectable		 2bxmA-3bs8A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 10 ILE A 417
ILE A 337
GLY A 358
PRO A 395
VAL A 392
 None
 1.12A 3elzB-3bs8A:
undetectable		 3elzB-3bs8A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 9 ALA A 278
GLY A 118
PRO A  64
VAL A 269
ILE A 270
 None
PMP  A 431 (-3.6A)
None
None
None
 1.19A 3em4B-3bs8A:
undetectable		 3em4B-3bs8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 12 VAL A  32
MET A  39
ILE A  37
ILE A  56
HIS A 408
 None
 1.27A 3g8iA-3bs8A:
undetectable		 3g8iA-3bs8A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		3 / 3 SER A 117
GLY A 118
THR A 119
 PMP  A 431 ( 3.8A)
PMP  A 431 (-3.6A)
PMP  A 431 (-3.4A)
 0.15A 3k9wA-3bs8A:
undetectable		 3k9wA-3bs8A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 10 THR A 122
GLY A 149
GLU A 120
LEU A 152
LEU A 153
 PMP  A 431 ( 4.4A)
None
None
None
None
 1.16A 3kvrA-3bs8A:
undetectable		 3kvrA-3bs8A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 9 THR A 122
GLY A 149
GLU A 120
LEU A 152
LEU A 153
 PMP  A 431 ( 4.4A)
None
None
None
None
 1.14A 3nbqA-3bs8A:
undetectable		 3nbqA-3bs8A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 10 ALA A 125
ILE A 285
GLY A 281
VAL A 109
ILE A 238
 None
 1.09A 3oxvB-3bs8A:
undetectable		 3oxvB-3bs8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 10 ALA A 125
ILE A 285
GLY A 281
VAL A 109
ILE A 238
 None
 0.99A 3oxwB-3bs8A:
undetectable		 3oxwB-3bs8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 11 ALA A 125
ILE A 285
GLY A 281
VAL A 109
ILE A 238
 None
 0.98A 3oxxD-3bs8A:
undetectable		 3oxxD-3bs8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		4 / 4 GLY A 271
GLY A 311
THR A 309
LEU A  78
 None
 0.92A 3si7C-3bs8A:
undetectable
3si7D-3bs8A:
undetectable		 3si7C-3bs8A:
22.94
3si7D-3bs8A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 12 LEU A 402
ILE A  56
ILE A 413
PHE A 359
TYR A 384
 None
 1.27A 4a79A-3bs8A:
undetectable		 4a79A-3bs8A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 11 LEU A 402
ILE A  56
ILE A 413
PHE A 359
TYR A 384
 None
 1.31A 4a7aA-3bs8A:
undetectable		 4a7aA-3bs8A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		4 / 8 LEU A 315
VAL A 102
VAL A 106
GLN A 254
 None
 0.98A 4em2A-3bs8A:
undetectable		 4em2A-3bs8A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		4 / 6 PHE A 359
ILE A 346
PRO A 347
PHE A 350
 None
 1.07A 4fgkA-3bs8A:
undetectable		 4fgkA-3bs8A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		4 / 6 GLY A 281
GLY A 280
GLU A 110
ILE A 103
 None
 0.92A 4fglD-3bs8A:
undetectable		 4fglD-3bs8A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		4 / 8 GLY A  63
GLY A 273
LEU A 274
VAL A 276
 None
 0.79A 4fgzA-3bs8A:
undetectable		 4fgzA-3bs8A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		4 / 8 GLY A  63
GLY A 273
LEU A 274
VAL A 276
 None
 0.79A 4fgzB-3bs8A:
undetectable		 4fgzB-3bs8A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		4 / 6 LEU A 394
TYR A 383
ILE A 337
GLY A 358
 None
 0.96A 4l39A-3bs8A:
0.9		 4l39A-3bs8A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 9 ALA A 278
GLY A 118
PRO A  64
VAL A 269
ILE A 270
 None
PMP  A 431 (-3.6A)
None
None
None
 1.24A 4ll3B-3bs8A:
undetectable		 4ll3B-3bs8A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 12 ILE A 238
HIS A 146
ARG A 130
LEU A 126
LEU A 152
 None
 1.30A 4pbhA-3bs8A:
undetectable		 4pbhA-3bs8A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_C_PARC500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 10 SER A 117
THR A 122
SER A 124
TYR A 279
GLY A 147
 PMP  A 431 ( 3.8A)
PMP  A 431 ( 4.4A)
None
None
PMP  A 431 ( 3.7A)
 1.33A 4qb9C-3bs8A:
0.0		 4qb9C-3bs8A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_C_PARC500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 10 SER A 117
THR A 122
SER A 124
TYR A 279
TYR A 145
 PMP  A 431 ( 3.8A)
PMP  A 431 ( 4.4A)
None
None
None
 1.45A 4qb9C-3bs8A:
0.0		 4qb9C-3bs8A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 12 SER A 117
THR A 122
SER A 124
TYR A 279
GLY A 147
 PMP  A 431 ( 3.8A)
PMP  A 431 ( 4.4A)
None
None
PMP  A 431 ( 3.7A)
 1.18A 4qb9E-3bs8A:
undetectable		 4qb9E-3bs8A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 12 SER A 117
THR A 122
SER A 124
TYR A 279
TYR A 145
 PMP  A 431 ( 3.8A)
PMP  A 431 ( 4.4A)
None
None
None
 1.45A 4qb9E-3bs8A:
undetectable		 4qb9E-3bs8A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 12 GLY A 214
GLU A 400
GLY A 401
ALA A 372
THR A 371
 None
 0.66A 4uckA-3bs8A:
undetectable		 4uckA-3bs8A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		4 / 6 LEU A 306
PHE A  88
THR A  92
VAL A  94
 None
 0.91A 4udaA-3bs8A:
undetectable		 4udaA-3bs8A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 12 GLY A 281
ILE A 175
GLY A 149
THR A 119
THR A 264
 None
None
None
PMP  A 431 (-3.4A)
None
 1.05A 4zdyA-3bs8A:
undetectable		 4zdyA-3bs8A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 12 GLY A 281
ILE A 175
GLY A 149
THR A 119
THR A 264
 None
None
None
PMP  A 431 (-3.4A)
None
 1.15A 4ze2A-3bs8A:
undetectable		 4ze2A-3bs8A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 12 GLY A 281
ILE A 175
GLY A 149
THR A 119
THR A 264
 None
None
None
PMP  A 431 (-3.4A)
None
 1.11A 5eskA-3bs8A:
undetectable		 5eskA-3bs8A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 12 GLY A 281
ILE A 175
GLY A 149
THR A 119
THR A 264
 None
None
None
PMP  A 431 (-3.4A)
None
 1.04A 5eslA-3bs8A:
undetectable		 5eslA-3bs8A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		3 / 3 GLY A 147
LEU A 152
HIS A 146
 PMP  A 431 ( 3.7A)
None
None
 0.63A 5u63A-3bs8A:
undetectable		 5u63A-3bs8A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		3 / 3 GLY A 147
LEU A 152
HIS A 146
 PMP  A 431 ( 3.7A)
None
None
 0.63A 5u63B-3bs8A:
1.7		 5u63B-3bs8A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		5 / 12 GLY A 281
ILE A 175
GLY A 149
THR A 119
THR A 264
 None
None
None
PMP  A 431 (-3.4A)
None
 1.11A 6e8qA-3bs8A:
undetectable		 6e8qA-3bs8A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Bacillus
subtilis) 		4 / 7 ASP A 412
GLY A  42
SER A  45
GLY A  44
 None
 0.84A 6ekzA-3bs8A:
undetectable		 6ekzA-3bs8A:
11.79