SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3btp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 3btp SINGLE-STRAND
DNA-BINDING PROTEIN
(Agrobacterium
fabrum) 		4 / 8 LEU A 151
ILE A 265
VAL A 120
ILE A 118
 None
 0.69A 1d4yB-3btpA:
undetectable		 1d4yB-3btpA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 3btp SINGLE-STRAND
DNA-BINDING PROTEIN
(Agrobacterium
fabrum) 		4 / 6 LEU A 515
ILE A 454
ASP A 466
PRO A 465
 None
 1.02A 1ditH-3btpA:
undetectable
1ditP-3btpA:
undetectable		 1ditH-3btpA:
18.35
1ditP-3btpA:
3.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 3btp PROTEIN VIRE1
SINGLE-STRAND
DNA-BINDING PROTEIN
(Agrobacterium
fabrum) 		4 / 8 PHE B  36
THR B  37
HIS A 315
ILE B  44
 NH4  B 602 ( 4.6A)
None
None
None
 0.99A 1ei6D-3btpB:
undetectable		 1ei6D-3btpB:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 3btp SINGLE-STRAND
DNA-BINDING PROTEIN
(Agrobacterium
fabrum) 		4 / 6 ILE A 305
LYS A 296
LYS A 298
ALA A 294
 None
 1.27A 1hk2A-3btpA:
undetectable		 1hk2A-3btpA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 3btp SINGLE-STRAND
DNA-BINDING PROTEIN
(Agrobacterium
fabrum) 		5 / 12 THR A 217
TYR A 250
ILE A 246
ILE A 236
TYR A 235
 None
 1.12A 1jtxA-3btpA:
undetectable		 1jtxA-3btpA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA8_0
(GRAMICIDIN A)		 3btp SINGLE-STRAND
DNA-BINDING PROTEIN
(Agrobacterium
fabrum) 		4 / 4 GLY A 434
VAL A 431
TRP A 393
GLY A 390
 None
 1.17A 1ng8A-3btpA:
undetectable		 1ng8A-3btpA:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB8_0
(GRAMICIDIN A)		 3btp SINGLE-STRAND
DNA-BINDING PROTEIN
(Agrobacterium
fabrum) 		4 / 4 GLY A 434
VAL A 431
TRP A 393
GLY A 390
 None
 1.17A 1ng8B-3btpA:
undetectable		 1ng8B-3btpA:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3btp SINGLE-STRAND
DNA-BINDING PROTEIN
(Agrobacterium
fabrum) 		4 / 4 ASP A 262
ASP A 126
ASP A 281
GLY A 242
 None
 1.17A 2igtC-3btpA:
undetectable		 2igtC-3btpA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 3btp SINGLE-STRAND
DNA-BINDING PROTEIN
(Agrobacterium
fabrum) 		4 / 8 GLU A 338
ARG A 340
ASP A 329
PHE A 332
 None
 1.07A 3mjrD-3btpA:
undetectable		 3mjrD-3btpA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 3btp SINGLE-STRAND
DNA-BINDING PROTEIN
(Agrobacterium
fabrum) 		3 / 3 LEU A 264
ARG A 113
ASN A 135
 None
 0.72A 3qxvD-3btpA:
undetectable		 3qxvD-3btpA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3btp SINGLE-STRAND
DNA-BINDING PROTEIN
(Agrobacterium
fabrum) 		3 / 3 TYR A 117
LEU A 307
LYS A 308
 None
 0.75A 3sueD-3btpA:
undetectable		 3sueD-3btpA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3btp SINGLE-STRAND
DNA-BINDING PROTEIN
PROTEIN VIRE1
(Agrobacterium
fabrum;
Agrobacterium
fabrum) 		5 / 12 ASP B  40
GLY B  35
TYR A 250
SER A 311
HIS B  31
 None
NH4  B 603 (-3.7A)
None
None
None
 1.13A 4blvB-3btpB:
undetectable		 4blvB-3btpB:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 3btp SINGLE-STRAND
DNA-BINDING PROTEIN
(Agrobacterium
fabrum) 		3 / 3 ARG A 244
ASP A 262
TYR A 241
 None
 0.96A 4yo9B-3btpA:
undetectable		 4yo9B-3btpA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 3btp SINGLE-STRAND
DNA-BINDING PROTEIN
(Agrobacterium
fabrum) 		3 / 3 PRO A 161
LEU A 264
SER A 258
 None
 0.78A 5fsaB-3btpA:
undetectable		 5fsaB-3btpA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 3btp SINGLE-STRAND
DNA-BINDING PROTEIN
(Agrobacterium
fabrum) 		5 / 12 ASP A 115
ILE A 263
THR A 132
ALA A 294
GLU A 304
 None
 1.13A 5vcgA-3btpA:
undetectable		 5vcgA-3btpA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 3btp SINGLE-STRAND
DNA-BINDING PROTEIN
(Agrobacterium
fabrum) 		4 / 4 HIS A 419
VAL A 398
LEU A 423
ALA A 400
 None
 1.23A 6d8pB-3btpA:
undetectable		 6d8pB-3btpA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 3btp SINGLE-STRAND
DNA-BINDING PROTEIN
PROTEIN VIRE1
(Agrobacterium
fabrum;
Agrobacterium
fabrum) 		4 / 7 ASP B  40
GLY A 257
SER A 311
GLY A 312
 None
 0.90A 6ekzA-3btpB:
undetectable		 6ekzA-3btpB:
16.25