SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3btu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3btu GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Saccharomyces
cerevisiae) 		5 / 11 ILE A  90
VAL A  91
LEU A  52
THR A  73
ILE A  92
 None
 1.26A 1pkvA-3btuA:
undetectable
1pkvB-3btuA:
undetectable		 1pkvA-3btuA:
13.20
1pkvB-3btuA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 3btu GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 310
GLY A 180
ILE A 158
MET A 221
LEU A 305
 None
 0.97A 1x7pA-3btuA:
undetectable
1x7pB-3btuA:
2.7		 1x7pA-3btuA:
22.05
1x7pB-3btuA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 3btu GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 310
GLY A 180
ILE A 158
MET A 221
LEU A 305
 None
 0.97A 1x7pA-3btuA:
undetectable
1x7pB-3btuA:
2.5		 1x7pA-3btuA:
22.05
1x7pB-3btuA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 3btu GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 368
GLN A 370
ILE A 147
PHE A  47
PHE A 399
 None
 1.24A 2q6hA-3btuA:
undetectable		 2q6hA-3btuA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 3btu GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 279
TYR A 185
THR A 209
TRP A 184
 None
 1.47A 2q6kA-3btuA:
undetectable		 2q6kA-3btuA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 3btu GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 368
GLN A 370
ILE A 147
PHE A  47
PHE A 399
 None
 1.27A 2qeiA-3btuA:
undetectable		 2qeiA-3btuA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3btu GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Saccharomyces
cerevisiae) 		5 / 12 PHE A  22
SER A  60
THR A  59
GLY A  30
ALA A  32
 None
 1.22A 2x2iC-3btuA:
undetectable		 2x2iC-3btuA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 3btu GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Saccharomyces
cerevisiae) 		4 / 7 ARG A 153
PHE A 399
PHE A 389
ILE A 147
 None
 1.04A 2zseA-3btuA:
undetectable		 2zseA-3btuA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 3btu GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  78
VAL A 102
ILE A 148
VAL A  23
HIS A 409
 None
 1.25A 3sp9B-3btuA:
undetectable		 3sp9B-3btuA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3btu GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 182
GLY A 282
ILE A 178
LEU A 292
GLY A 310
 None
 1.08A 4yvgA-3btuA:
undetectable		 4yvgA-3btuA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3btu GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 147
ALA A 139
VAL A 144
VAL A 121
 None
 0.80A 5ecnD-3btuA:
undetectable		 5ecnD-3btuA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 3btu GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 122
LEU A  25
GLY A  24
ILE A  33
ALA A  28
 None
 1.07A 5j7wD-3btuA:
undetectable		 5j7wD-3btuA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 3btu GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 152
LEU A 150
HIS A 213
 None
 0.69A 5u63A-3btuA:
3.0		 5u63A-3btuA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3btu GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 182
GLY A 282
ILE A 178
LEU A 292
GLY A 310
 None
 1.07A 5wyqA-3btuA:
undetectable		 5wyqA-3btuA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3btu GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 268
VAL A 273
VAL A 275
ILE A 296
 None
 0.67A 5y9mA-3btuA:
undetectable		 5y9mA-3btuA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3btu GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 268
VAL A 273
VAL A 275
ILE A 296
 None
 0.66A 5y9mX-3btuA:
undetectable		 5y9mX-3btuA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 3btu GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 303
ILE A 170
GLY A 301
VAL A 293
ILE A 296
 None
 1.06A 6emuC-3btuA:
2.9		 6emuC-3btuA:
19.29