SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3buu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 3buu UNCHARACTERIZED LOLA
SUPERFAMILY PROTEIN
NE2245
(Nitrosomonas
europaea) 		4 / 8 SER A  84
TYR A 204
VAL A 129
VAL A  58
 None
 0.99A 2y05A-3buuA:
undetectable
2y05B-3buuA:
undetectable		 2y05A-3buuA:
22.32
2y05B-3buuA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 3buu UNCHARACTERIZED LOLA
SUPERFAMILY PROTEIN
NE2245
(Nitrosomonas
europaea) 		4 / 7 VAL A  58
TYR A  74
GLY A 132
VAL A 129
 None
 0.84A 2y05A-3buuA:
undetectable
2y05B-3buuA:
undetectable		 2y05A-3buuA:
22.32
2y05B-3buuA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 3buu UNCHARACTERIZED LOLA
SUPERFAMILY PROTEIN
NE2245
(Nitrosomonas
europaea) 		5 / 12 ILE A  99
ASP A 167
ILE A 166
ASP A 142
ARG A 136
 None
 1.45A 3phaB-3buuA:
undetectable		 3phaB-3buuA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 3buu UNCHARACTERIZED LOLA
SUPERFAMILY PROTEIN
NE2245
(Nitrosomonas
europaea) 		3 / 3 ARG A  48
PHE A  49
PRO A  50
 None
 0.81A 3zoaB-3buuA:
undetectable		 3zoaB-3buuA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 3buu UNCHARACTERIZED LOLA
SUPERFAMILY PROTEIN
NE2245
(Nitrosomonas
europaea) 		5 / 12 ASP A 167
ILE A 166
ASP A 142
GLU A  82
ARG A 136
 None
 1.43A 4b9zA-3buuA:
undetectable		 4b9zA-3buuA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3buu UNCHARACTERIZED LOLA
SUPERFAMILY PROTEIN
NE2245
(Nitrosomonas
europaea) 		5 / 10 THR A 171
SER A 120
VAL A 108
ALA A 135
ILE A  99
 None
 1.07A 4lbgA-3buuA:
undetectable		 4lbgA-3buuA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3buu UNCHARACTERIZED LOLA
SUPERFAMILY PROTEIN
NE2245
(Nitrosomonas
europaea) 		4 / 6 GLY A 127
GLU A  69
ASP A 223
ASP A 133
 None
 0.91A 4uckB-3buuA:
undetectable		 4uckB-3buuA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 3buu UNCHARACTERIZED LOLA
SUPERFAMILY PROTEIN
NE2245
(Nitrosomonas
europaea) 		4 / 6 LEU A  41
ASP A  45
PHE A 139
ILE A 166
 None
 1.22A 4y4dA-3buuA:
undetectable		 4y4dA-3buuA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 3buu UNCHARACTERIZED LOLA
SUPERFAMILY PROTEIN
NE2245
(Nitrosomonas
europaea) 		4 / 6 GLY A 127
THR A 126
SER A 231
VAL A 129
 None
 1.08A 5ewuA-3buuA:
undetectable		 5ewuA-3buuA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 3buu UNCHARACTERIZED LOLA
SUPERFAMILY PROTEIN
NE2245
(Nitrosomonas
europaea) 		3 / 3 LEU A 148
ASP A 157
ILE A 153
 None
 0.57A 6dh0B-3buuA:
undetectable		 6dh0B-3buuA:
19.21