SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3buz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3buz IOTA TOXIN COMPONENT
IA
(Clostridium
perfringens) 		4 / 8 SER A  50
GLN A 181
PHE A 136
ASN A  51
 None
 1.08A 1p6kA-3buzA:
undetectable		 1p6kA-3buzA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3buz IOTA TOXIN COMPONENT
IA
(Clostridium
perfringens) 		4 / 8 SER A  50
GLN A 181
PHE A 136
ASN A  51
 None
 1.08A 1zzqA-3buzA:
undetectable		 1zzqA-3buzA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3buz IOTA TOXIN COMPONENT
IA
(Clostridium
perfringens) 		4 / 8 SER A  50
GLN A 181
PHE A 136
ASN A  51
 None
 1.06A 1zzqB-3buzA:
undetectable		 1zzqB-3buzA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 3buz IOTA TOXIN COMPONENT
IA
(Clostridium
perfringens) 		4 / 7 ARG A 295
SER A 338
ARG A 352
GLU A 380
 TAD  A 500 (-3.2A)
TAD  A 500 (-3.2A)
TAD  A 500 (-2.7A)
TAD  A 500 (-2.6A)
 0.67A 2c8aA-3buzA:
23.1		 2c8aA-3buzA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 3buz IOTA TOXIN COMPONENT
IA
(Clostridium
perfringens) 		4 / 7 ARG A 295
SER A 338
ARG A 352
GLU A 380
 TAD  A 500 (-3.2A)
TAD  A 500 (-3.2A)
TAD  A 500 (-2.7A)
TAD  A 500 (-2.6A)
 0.75A 2c8aB-3buzA:
22.9		 2c8aB-3buzA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 3buz IOTA TOXIN COMPONENT
IA
(Clostridium
perfringens) 		4 / 6 ARG A 295
SER A 338
ARG A 352
GLU A 380
 TAD  A 500 (-3.2A)
TAD  A 500 (-3.2A)
TAD  A 500 (-2.7A)
TAD  A 500 (-2.6A)
 0.61A 2c8aC-3buzA:
22.6		 2c8aC-3buzA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 3buz IOTA TOXIN COMPONENT
IA
(Clostridium
perfringens) 		4 / 7 ARG A 295
SER A 338
ARG A 352
GLU A 380
 TAD  A 500 (-3.2A)
TAD  A 500 (-3.2A)
TAD  A 500 (-2.7A)
TAD  A 500 (-2.6A)
 0.67A 2c8aD-3buzA:
18.4		 2c8aD-3buzA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 3buz IOTA TOXIN COMPONENT
IA
(Clostridium
perfringens) 		4 / 7 LEU A 258
ILE A 337
SER A 387
TYR A 251
 None
None
None
TAD  A 500 (-4.1A)
 1.14A 2hc4A-3buzA:
undetectable		 2hc4A-3buzA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 3buz IOTA TOXIN COMPONENT
IA
(Clostridium
perfringens) 		4 / 8 ARG A 296
ILE A 354
GLY A 303
PHE A 302
 None
 0.84A 2tsrB-3buzA:
undetectable		 2tsrB-3buzA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1353_1
(PROSTAGLANDIN
REDUCTASE 2)		 3buz IOTA TOXIN COMPONENT
IA
(Clostridium
perfringens) 		5 / 9 THR A 339
PHE A 336
VAL A 293
GLY A 366
ILE A 287
 None
 1.37A 2w98A-3buzA:
undetectable		 2w98A-3buzA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC202_1
(PROTEIN S100-A4)		 3buz IOTA TOXIN COMPONENT
IA
(Clostridium
perfringens) 		5 / 11 ASP A 134
LEU A 356
ILE A 391
PHE A 100
ASP A 395
 None
 1.18A 3ko0A-3buzA:
undetectable
3ko0B-3buzA:
undetectable
3ko0C-3buzA:
undetectable
3ko0D-3buzA:
undetectable		 3ko0A-3buzA:
12.71
3ko0B-3buzA:
12.71
3ko0C-3buzA:
12.71
3ko0D-3buzA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)		 3buz IOTA TOXIN COMPONENT
IA
(Clostridium
perfringens) 		5 / 11 ASP A 395
LEU A 356
ILE A 391
PHE A 100
ASP A 134
 None
 1.21A 3ko0C-3buzA:
undetectable
3ko0D-3buzA:
undetectable
3ko0E-3buzA:
undetectable
3ko0F-3buzA:
undetectable		 3ko0C-3buzA:
12.71
3ko0D-3buzA:
12.71
3ko0E-3buzA:
12.71
3ko0F-3buzA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 3buz IOTA TOXIN COMPONENT
IA
(Clostridium
perfringens) 		5 / 12 LEU A 356
ILE A 391
PHE A 100
ASP A 395
ASP A 134
 None
 1.19A 3ko0M-3buzA:
undetectable
3ko0N-3buzA:
undetectable
3ko0O-3buzA:
undetectable
3ko0P-3buzA:
undetectable		 3ko0M-3buzA:
12.71
3ko0N-3buzA:
12.71
3ko0O-3buzA:
12.71
3ko0P-3buzA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)		 3buz IOTA TOXIN COMPONENT
IA
(Clostridium
perfringens) 		5 / 11 LEU A 356
ILE A 391
PHE A 100
ASP A 395
ASP A 134
 None
 1.21A 3ko0O-3buzA:
undetectable
3ko0P-3buzA:
undetectable
3ko0Q-3buzA:
undetectable
3ko0R-3buzA:
undetectable		 3ko0O-3buzA:
12.71
3ko0P-3buzA:
12.71
3ko0Q-3buzA:
12.71
3ko0R-3buzA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 3buz IOTA TOXIN COMPONENT
IA
(Clostridium
perfringens) 		4 / 8 SER A  50
GLN A 181
PHE A 136
ASN A  51
 None
 1.10A 3n62B-3buzA:
undetectable		 3n62B-3buzA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 3buz IOTA TOXIN COMPONENT
IA
(Clostridium
perfringens) 		3 / 3 ASP A 212
GLU A 180
SER A 340
 None
 0.75A 3p2kA-3buzA:
undetectable		 3p2kA-3buzA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 3buz IOTA TOXIN COMPONENT
IA
(Clostridium
perfringens) 		4 / 4 LEU A 304
ILE A 354
GLY A 303
PHE A 322
 None
 1.05A 4dc3A-3buzA:
undetectable		 4dc3A-3buzA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 3buz IOTA TOXIN COMPONENT
IA
(Clostridium
perfringens) 		4 / 5 LEU A 304
TRP A 326
ILE A 331
ASN A 335
 None
None
None
TAD  A 500 (-2.8A)
 1.35A 4i00A-3buzA:
undetectable		 4i00A-3buzA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA305_0
(THAUMATIN-1)		 3buz IOTA TOXIN COMPONENT
IA
(Clostridium
perfringens) 		4 / 5 LYS A  11
GLU A 143
ILE A 193
VAL A 191
 None
 1.29A 4tvtA-3buzA:
0.0		 4tvtA-3buzA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3buz IOTA TOXIN COMPONENT
IA
(Clostridium
perfringens) 		3 / 3 SER A 229
ASP A 212
ASP A 221
 None
 0.81A 4uckA-3buzA:
undetectable		 4uckA-3buzA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3buz IOTA TOXIN COMPONENT
IA
(Clostridium
perfringens) 		4 / 6 SER A 229
GLY A 220
ASP A 212
ASP A 221
 None
 0.87A 4uckB-3buzA:
undetectable		 4uckB-3buzA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 3buz IOTA TOXIN COMPONENT
IA
(Clostridium
perfringens) 		4 / 7 ARG A 295
SER A 338
GLU A 378
GLU A 380
 TAD  A 500 (-3.2A)
TAD  A 500 (-3.2A)
None
TAD  A 500 (-2.6A)
 0.87A 4xzkA-3buzA:
10.4		 4xzkA-3buzA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 3buz IOTA TOXIN COMPONENT
IA
(Clostridium
perfringens) 		4 / 7 TYR A 251
ARG A 295
SER A 338
GLU A 380
 TAD  A 500 (-4.1A)
TAD  A 500 (-3.2A)
TAD  A 500 (-3.2A)
TAD  A 500 (-2.6A)
 0.62A 4xzkA-3buzA:
10.4		 4xzkA-3buzA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 3buz IOTA TOXIN COMPONENT
IA
(Clostridium
perfringens) 		5 / 12 TYR A 375
SER A 364
ILE A 287
VAL A 381
VAL A 293
 None
 1.04A 5dpdA-3buzA:
undetectable		 5dpdA-3buzA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 3buz IOTA TOXIN COMPONENT
IA
(Clostridium
perfringens) 		5 / 12 TYR A 375
SER A 364
ILE A 287
VAL A 381
VAL A 293
 None
 1.00A 5dpdB-3buzA:
undetectable		 5dpdB-3buzA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3buz IOTA TOXIN COMPONENT
IA
(Clostridium
perfringens) 		4 / 4 LEU A 154
ARG A 107
ILE A 106
ILE A 114
 None
 1.29A 5dzk2-3buzA:
undetectable
5dzkM-3buzA:
undetectable
5dzkN-3buzA:
undetectable		 5dzk2-3buzA:
1.29
5dzkM-3buzA:
17.92
5dzkN-3buzA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 3buz IOTA TOXIN COMPONENT
IA
(Clostridium
perfringens) 		5 / 12 ILE A  17
GLU A  14
TRP A  19
THR A 177
LEU A 141
 None
 1.36A 5fhzD-3buzA:
undetectable		 5fhzD-3buzA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 3buz IOTA TOXIN COMPONENT
IA
(Clostridium
perfringens) 		3 / 3 ASP A 212
SER A 343
TYR A 294
 None
 0.67A 5glmA-3buzA:
undetectable		 5glmA-3buzA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 3buz IOTA TOXIN COMPONENT
IA
(Clostridium
perfringens) 		4 / 8 PRO A 334
TYR A 333
THR A 332
ILE A 331
 TAD  A 500 (-4.6A)
TAD  A 500 (-4.4A)
None
None
 0.71A 5mzrE-3buzA:
undetectable		 5mzrE-3buzA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 3buz IOTA TOXIN COMPONENT
IA
(Clostridium
perfringens) 		4 / 7 ILE A 179
GLN A 181
GLU A  95
VAL A 139
 None
 0.93A 6j20A-3buzA:
undetectable		 6j20A-3buzA:
20.76