SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bv6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 3bv6 METAL-DEPENDENT
HYDROLASE
(Vibrio
cholerae) 		3 / 3 ALA A 146
VAL A 148
TRP A 151
 None
 0.89A 1av2C-3bv6A:
undetectable
1av2D-3bv6A:
undetectable		 1av2C-3bv6A:
6.07
1av2D-3bv6A:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 3bv6 METAL-DEPENDENT
HYDROLASE
(Vibrio
cholerae) 		4 / 5 ASP A 227
HIS A 282
HIS A 117
HIS A 122
 FE  A 401 ( 2.5A)
FE  A 402 (-3.4A)
FE  A 401 (-3.1A)
FE  A 402 (-3.3A)
 1.05A 1ei6A-3bv6A:
undetectable		 1ei6A-3bv6A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 3bv6 METAL-DEPENDENT
HYDROLASE
(Vibrio
cholerae) 		5 / 8 ASP A 184
ASP A 227
HIS A 282
HIS A 117
HIS A 122
 FE  A 401 (-2.9A)
FE  A 401 ( 2.5A)
FE  A 402 (-3.4A)
FE  A 401 (-3.1A)
FE  A 402 (-3.3A)
 1.13A 1ei6C-3bv6A:
undetectable		 1ei6C-3bv6A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IHI_A_IU5A326_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 3bv6 METAL-DEPENDENT
HYDROLASE
(Vibrio
cholerae) 		5 / 10 VAL A 113
VAL A 131
ILE A 107
TRP A  49
LEU A  43
 None
 1.23A 1ihiA-3bv6A:
0.6		 1ihiA-3bv6A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA6_0
(GRAMICIDIN A)		 3bv6 METAL-DEPENDENT
HYDROLASE
(Vibrio
cholerae) 		3 / 3 ALA A 146
VAL A 148
TRP A 151
 None
 0.87A 1nt5A-3bv6A:
undetectable		 1nt5A-3bv6A:
4.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 3bv6 METAL-DEPENDENT
HYDROLASE
(Vibrio
cholerae) 		3 / 3 ALA A 146
VAL A 148
TRP A 151
 None
 0.87A 1nt5B-3bv6A:
undetectable		 1nt5B-3bv6A:
4.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 3bv6 METAL-DEPENDENT
HYDROLASE
(Vibrio
cholerae) 		3 / 3 ALA A 146
VAL A 148
TRP A 151
 None
 0.75A 1nt6A-3bv6A:
undetectable		 1nt6A-3bv6A:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 3bv6 METAL-DEPENDENT
HYDROLASE
(Vibrio
cholerae) 		3 / 3 ALA A 146
VAL A 148
TRP A 151
 None
 0.75A 1nt6B-3bv6A:
undetectable		 1nt6B-3bv6A:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 3bv6 METAL-DEPENDENT
HYDROLASE
(Vibrio
cholerae) 		3 / 3 TRP A 151
ALA A 146
VAL A 148
 None
 0.85A 2izqA-3bv6A:
undetectable
2izqB-3bv6A:
undetectable		 2izqA-3bv6A:
6.07
2izqB-3bv6A:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 3bv6 METAL-DEPENDENT
HYDROLASE
(Vibrio
cholerae) 		4 / 5 LEU A 102
PRO A 101
LEU A  24
ILE A  28
 None
 0.57A 2qd4A-3bv6A:
undetectable		 2qd4A-3bv6A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 3bv6 METAL-DEPENDENT
HYDROLASE
(Vibrio
cholerae) 		3 / 3 GLY A 220
TYR A 324
SER A 221
 None
 0.76A 2xatA-3bv6A:
undetectable		 2xatA-3bv6A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUR_A_TESA339_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 3bv6 METAL-DEPENDENT
HYDROLASE
(Vibrio
cholerae) 		5 / 10 ILE A 123
TRP A 151
SER A 182
VAL A 166
VAL A 179
 None
 1.29A 3burA-3bv6A:
undetectable		 3burA-3bv6A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3bv6 METAL-DEPENDENT
HYDROLASE
(Vibrio
cholerae) 		4 / 7 ALA A 115
ILE A  60
HIS A 224
GLY A 226
 None
 0.86A 3v4tH-3bv6A:
undetectable		 3v4tH-3bv6A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3bv6 METAL-DEPENDENT
HYDROLASE
(Vibrio
cholerae) 		4 / 4 LEU A 102
PRO A 101
LEU A  24
ILE A  28
 None
 0.56A 4f4dB-3bv6A:
undetectable		 4f4dB-3bv6A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3bv6 METAL-DEPENDENT
HYDROLASE
(Vibrio
cholerae) 		5 / 8 VAL A 113
VAL A 131
ILE A 107
TRP A  49
LEU A  43
 None
 1.21A 4jq1B-3bv6A:
undetectable		 4jq1B-3bv6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQA_A_ID8A401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3bv6 METAL-DEPENDENT
HYDROLASE
(Vibrio
cholerae) 		5 / 9 VAL A 113
VAL A 131
ILE A 107
TRP A  49
LEU A  43
 None
 1.28A 4jqaA-3bv6A:
1.2		 4jqaA-3bv6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQA_B_ID8B401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3bv6 METAL-DEPENDENT
HYDROLASE
(Vibrio
cholerae) 		5 / 9 VAL A 113
VAL A 131
ILE A 107
TRP A  49
LEU A  43
 None
 1.23A 4jqaB-3bv6A:
1.1		 4jqaB-3bv6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3bv6 METAL-DEPENDENT
HYDROLASE
(Vibrio
cholerae) 		5 / 10 VAL A 113
VAL A 131
ILE A 107
TRP A  49
LEU A  43
 None
 1.27A 4jtqA-3bv6A:
undetectable		 4jtqA-3bv6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_B_FLPB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3bv6 METAL-DEPENDENT
HYDROLASE
(Vibrio
cholerae) 		5 / 9 VAL A 113
VAL A 131
ILE A 107
TRP A  49
LEU A  43
 None
 1.25A 4jtqB-3bv6A:
0.6		 4jtqB-3bv6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3bv6 METAL-DEPENDENT
HYDROLASE
(Vibrio
cholerae) 		4 / 5 LEU A 102
PRO A 101
LEU A  24
ILE A  28
 None
 0.60A 4klrA-3bv6A:
undetectable		 4klrA-3bv6A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_1
(ADENOSINE KINASE)		 3bv6 METAL-DEPENDENT
HYDROLASE
(Vibrio
cholerae) 		5 / 12 LEU A 114
ALA A 112
ASN A  55
GLY A  54
ASP A 174
 None
 1.18A 4n09A-3bv6A:
undetectable		 4n09A-3bv6A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3bv6 METAL-DEPENDENT
HYDROLASE
(Vibrio
cholerae) 		4 / 7 PRO A  18
SER A  59
PHE A  62
ASP A 103
 None
 1.28A 4odjA-3bv6A:
undetectable		 4odjA-3bv6A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3bv6 METAL-DEPENDENT
HYDROLASE
(Vibrio
cholerae) 		4 / 6 GLU A 297
ARG A 330
PHE A 314
HIS A 332
 None
 1.21A 4uciA-3bv6A:
undetectable		 4uciA-3bv6A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 3bv6 METAL-DEPENDENT
HYDROLASE
(Vibrio
cholerae) 		5 / 11 HIS A 117
HIS A 119
ASP A 121
HIS A 122
HIS A 282
 FE  A 401 (-3.1A)
FE  A 401 (-3.3A)
FE  A 402 (-2.6A)
FE  A 402 (-3.3A)
FE  A 402 (-3.4A)
 0.40A 5ayaA-3bv6A:
9.5		 5ayaA-3bv6A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 3bv6 METAL-DEPENDENT
HYDROLASE
(Vibrio
cholerae) 		4 / 7 TYR A 234
GLY A 226
SER A 249
LEU A 248
 None
 1.08A 5bphB-3bv6A:
undetectable		 5bphB-3bv6A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 3bv6 METAL-DEPENDENT
HYDROLASE
(Vibrio
cholerae) 		5 / 12 SER A 225
GLY A 226
ASP A 121
HIS A 282
PHE A 281
 None
None
FE  A 402 (-2.6A)
FE  A 402 (-3.4A)
None
 1.27A 5eeiA-3bv6A:
undetectable		 5eeiA-3bv6A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 3bv6 METAL-DEPENDENT
HYDROLASE
(Vibrio
cholerae) 		5 / 12 SER A 225
GLY A 226
ASP A 121
HIS A 282
PHE A 281
 None
None
FE  A 402 (-2.6A)
FE  A 402 (-3.4A)
None
 1.28A 5eeiB-3bv6A:
undetectable		 5eeiB-3bv6A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 3bv6 METAL-DEPENDENT
HYDROLASE
(Vibrio
cholerae) 		5 / 12 HIS A 122
GLY A 226
HIS A 117
LYS A 260
ASP A 259
 FE  A 402 (-3.3A)
None
FE  A 401 (-3.1A)
FE  A 402 ( 3.9A)
None
 1.12A 5hg0B-3bv6A:
undetectable		 5hg0B-3bv6A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3bv6 METAL-DEPENDENT
HYDROLASE
(Vibrio
cholerae) 		4 / 8 ASP A 227
HIS A 117
TRP A 286
HIS A 282
 FE  A 401 ( 2.5A)
FE  A 401 (-3.1A)
None
FE  A 402 (-3.4A)
 0.98A 5nekB-3bv6A:
undetectable		 5nekB-3bv6A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 3bv6 METAL-DEPENDENT
HYDROLASE
(Vibrio
cholerae) 		4 / 6 ASN A  57
THR A  56
ASN A  55
GLU A  29
 None
 1.32A 5uigA-3bv6A:
undetectable		 5uigA-3bv6A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 3bv6 METAL-DEPENDENT
HYDROLASE
(Vibrio
cholerae) 		4 / 5 THR A  46
HIS A 117
ASP A 184
HIS A 119
 None
FE  A 401 (-3.1A)
FE  A 401 (-2.9A)
FE  A 401 (-3.3A)
 1.11A 6dchA-3bv6A:
undetectable		 6dchA-3bv6A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_C_PCFC607_0
(CYTOCHROME B)		 3bv6 METAL-DEPENDENT
HYDROLASE
(Vibrio
cholerae) 		5 / 10 TRP A 154
PHE A  62
ALA A 128
PHE A 141
VAL A 113
 None
 1.47A 6hu9C-3bv6A:
undetectable		 6hu9C-3bv6A:
21.05