SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bvh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)
3bvh FIBRINOGEN GAMMA
CHAIN

(Homo
sapiens)
5 / 12 THR C 259
ALA C 260
ASP C 261
MET C 379
ILE C 367
None
0.97A 1errA-3bvhC:
undetectable
1errA-3bvhC:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)
3bvh FIBRINOGEN BETA
CHAIN
FIBRINOGEN GAMMA
CHAIN

(Homo
sapiens)
4 / 5 ILE B 179
SER B 170
LEU B 175
ASN C 117
None
1.05A 1y0xX-3bvhB:
undetectable
1y0xX-3bvhB:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_A_SAMA1217_0
(CATECHOL
O-METHYLTRANSFERASE)
3bvh FIBRINOGEN BETA
CHAIN

(Homo
sapiens)
5 / 12 MET B 447
GLY B 442
TYR B 445
TYR B 417
SER B 358
None
1.30A 2cl5A-3bvhB:
undetectable
2cl5A-3bvhB:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)
3bvh FIBRINOGEN BETA
CHAIN

(Homo
sapiens)
4 / 5 GLU B 210
PRO B 229
ILE B 227
GLY B 208
None
1.13A 2qeuA-3bvhB:
undetectable
2qeuC-3bvhB:
undetectable
2qeuA-3bvhB:
17.91
2qeuC-3bvhB:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)
3bvh FIBRINOGEN GAMMA
CHAIN

(Homo
sapiens)
5 / 10 ALA C 341
ALA C 289
LEU C 250
MET C 384
VAL C 248
None
1.09A 2wuzA-3bvhC:
undetectable
2wuzA-3bvhC:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)
3bvh FIBRINOGEN GAMMA
CHAIN

(Homo
sapiens)
5 / 10 ALA C 341
ALA C 289
LEU C 250
MET C 384
VAL C 248
None
1.07A 2wuzB-3bvhC:
undetectable
2wuzB-3bvhC:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
3bvh FIBRINOGEN GAMMA
CHAIN

(Homo
sapiens)
4 / 7 PHE C 290
ARG C 247
MET C 384
THR C 383
None
1.03A 3ag2N-3bvhC:
undetectable
3ag2W-3bvhC:
undetectable
3ag2N-3bvhC:
20.17
3ag2W-3bvhC:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)
3bvh FIBRINOGEN BETA
CHAIN

(Homo
sapiens)
5 / 12 MET B 447
GLY B 442
TYR B 445
TYR B 417
SER B 358
None
1.26A 3bwmA-3bvhB:
undetectable
3bwmA-3bvhB:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_0
(COMT PROTEIN)
3bvh FIBRINOGEN BETA
CHAIN

(Homo
sapiens)
5 / 12 MET B 447
GLY B 442
TYR B 445
TYR B 417
SER B 358
None
1.29A 3bwyA-3bvhB:
undetectable
3bwyA-3bvhB:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)
3bvh FIBRINOGEN GAMMA
CHAIN

(Homo
sapiens)
4 / 8 PRO C 360
ASN C 361
VAL C 347
GLY C 346
None
0.90A 3em0B-3bvhC:
undetectable
3em0B-3bvhC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_PNTA901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)
3bvh FIBRINOGEN BETA
CHAIN

(Homo
sapiens)
5 / 12 ASP B 398
GLY B 434
SER B 446
VAL B 436
TYR B 417
None
1.40A 3hiiA-3bvhB:
undetectable
3hiiA-3bvhB:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_PNTB901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)
3bvh FIBRINOGEN BETA
CHAIN

(Homo
sapiens)
5 / 12 ASP B 398
GLY B 434
SER B 446
VAL B 436
TYR B 417
None
1.38A 3hiiB-3bvhB:
undetectable
3hiiB-3bvhB:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)
3bvh FIBRINOGEN BETA
CHAIN

(Homo
sapiens)
4 / 7 PHE B 262
GLY B 414
GLY B 258
PHE B 375
None
0.89A 3ko0M-3bvhB:
undetectable
3ko0P-3bvhB:
undetectable
3ko0M-3bvhB:
16.38
3ko0P-3bvhB:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)
3bvh FIBRINOGEN GAMMA
CHAIN

(Homo
sapiens)
4 / 7 PHE C 204
GLY C 346
GLY C 200
PHE C 312
None
0.89A 3ko0M-3bvhC:
undetectable
3ko0P-3bvhC:
undetectable
3ko0M-3bvhC:
15.66
3ko0P-3bvhC:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)
3bvh FIBRINOGEN GAMMA
CHAIN

(Homo
sapiens)
3 / 3 LEU C 276
TRP C 334
GLY C 342
None
0.73A 3l35A-3bvhC:
2.7
3l35H-3bvhC:
undetectable
3l35A-3bvhC:
5.46
3l35H-3bvhC:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)
3bvh FIBRINOGEN GAMMA
CHAIN

(Homo
sapiens)
3 / 3 LEU C 276
TRP C 334
GLY C 342
None
0.69A 3l35B-3bvhC:
2.1
3l35K-3bvhC:
undetectable
3l35B-3bvhC:
5.46
3l35K-3bvhC:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)
3bvh FIBRINOGEN BETA
CHAIN

(Homo
sapiens)
3 / 3 GLU B 313
LEU B 311
LEU B 294
None
0.74A 3ohtA-3bvhB:
undetectable
3ohtA-3bvhB:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)
3bvh FIBRINOGEN BETA
CHAIN

(Homo
sapiens)
3 / 3 GLU B 313
LEU B 311
LEU B 294
None
0.75A 3ohtB-3bvhB:
undetectable
3ohtB-3bvhB:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
3bvh FIBRINOGEN GAMMA
CHAIN

(Homo
sapiens)
3 / 3 GLN C 210
THR C 314
ASN C 207
None
0.88A 3v4tE-3bvhC:
undetectable
3v4tE-3bvhC:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)
3bvh FIBRINOGEN BETA
CHAIN

(Homo
sapiens)
5 / 12 TYR B 269
GLY B 400
TYR B 378
ALA B 410
PHE B 375
None
1.22A 3vywB-3bvhB:
undetectable
3vywB-3bvhB:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)
3bvh FIBRINOGEN GAMMA
CHAIN

(Homo
sapiens)
4 / 8 ARG C 391
ASN C 189
ILE C 387
ASP C 152
None
1.08A 4d33A-3bvhC:
undetectable
4d33A-3bvhC:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)
3bvh FIBRINOGEN GAMMA
CHAIN

(Homo
sapiens)
4 / 7 ARG C 391
ASN C 189
ILE C 387
ASP C 152
None
1.09A 4d33B-3bvhC:
undetectable
4d33B-3bvhC:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)
3bvh FIBRINOGEN GAMMA
CHAIN

(Homo
sapiens)
4 / 7 ARG C 391
ASN C 189
ILE C 387
ASP C 152
None
1.08A 4d39B-3bvhC:
undetectable
4d39B-3bvhC:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)
3bvh FIBRINOGEN GAMMA
CHAIN

(Homo
sapiens)
3 / 3 LYS C 151
LYS C 170
PRO C 171
None
1.26A 4dv1L-3bvhC:
undetectable
4dv1L-3bvhC:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)
3bvh FIBRINOGEN ALPHA
CHAIN
FIBRINOGEN BETA
CHAIN

(Homo
sapiens)
5 / 10 TYR B 417
GLY B 258
SER B 446
GLY B 419
ASP A 153
None
1.42A 4mmcA-3bvhB:
undetectable
4mmcA-3bvhB:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)
3bvh FIBRINOGEN BETA
CHAIN

(Homo
sapiens)
5 / 9 ASP B 241
VAL B 238
TYR B 239
GLY B 248
SER B 222
None
1.23A 4mmeA-3bvhB:
undetectable
4mmeA-3bvhB:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)
3bvh FIBRINOGEN BETA
CHAIN

(Homo
sapiens)
5 / 9 ASP B 241
VAL B 238
TYR B 239
GLY B 248
SER B 222
None
1.22A 4mmeB-3bvhB:
undetectable
4mmeB-3bvhB:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)
3bvh FIBRINOGEN BETA
CHAIN

(Homo
sapiens)
5 / 9 ASP B 241
VAL B 238
TYR B 239
GLY B 248
SER B 222
None
1.27A 4mmfA-3bvhB:
undetectable
4mmfA-3bvhB:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)
3bvh FIBRINOGEN BETA
CHAIN

(Homo
sapiens)
5 / 9 ASP B 241
VAL B 238
TYR B 239
GLY B 248
SER B 222
None
1.22A 4mmfB-3bvhB:
undetectable
4mmfB-3bvhB:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)
3bvh FIBRINOGEN GAMMA
CHAIN

(Homo
sapiens)
5 / 12 GLY C 200
GLU C 225
ASN C 365
SER C 378
ILE C 367
None
1.21A 4pb1A-3bvhC:
undetectable
4pb1A-3bvhC:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)
3bvh FIBRINOGEN BETA
CHAIN

(Homo
sapiens)
5 / 12 MET B 447
GLY B 442
TYR B 445
TYR B 417
SER B 358
None
1.29A 4xudA-3bvhB:
undetectable
4xudA-3bvhB:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)
3bvh FIBRINOGEN BETA
CHAIN

(Homo
sapiens)
5 / 12 MET B 447
GLY B 442
TYR B 445
TYR B 417
SER B 358
None
1.28A 4xueB-3bvhB:
undetectable
4xueB-3bvhB:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)
3bvh FIBRINOGEN GAMMA
CHAIN

(Homo
sapiens)
3 / 3 TYR C 348
LYS C 381
LYS C 380
None
1.18A 5dbyA-3bvhC:
undetectable
5dbyA-3bvhC:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
3bvh FIBRINOGEN BETA
CHAIN

(Homo
sapiens)
5 / 12 ASP B 261
ASP B 398
THR B 431
GLY B 434
TYR B 417
None
1.18A 5hfjF-3bvhB:
undetectable
5hfjF-3bvhB:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)
3bvh FIBRINOGEN GAMMA
CHAIN

(Homo
sapiens)
3 / 3 GLY C 188
GLN C 154
LYS C 162
None
0.96A 5imsB-3bvhC:
undetectable
5imsB-3bvhC:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)
3bvh FIBRINOGEN GAMMA
CHAIN

(Homo
sapiens)
5 / 12 THR C 374
ALA C 370
SER C 355
ALA C 364
THR C 359
None
1.18A 5lf7V-3bvhC:
undetectable
5lf7b-3bvhC:
undetectable
5lf7V-3bvhC:
22.08
5lf7b-3bvhC:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)
3bvh FIBRINOGEN GAMMA
CHAIN

(Homo
sapiens)
5 / 12 THR C 374
ALA C 370
SER C 355
ALA C 364
THR C 359
None
1.19A 5lf7H-3bvhC:
undetectable
5lf7N-3bvhC:
undetectable
5lf7H-3bvhC:
22.08
5lf7N-3bvhC:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)
3bvh FIBRINOGEN ALPHA
CHAIN
FIBRINOGEN BETA
CHAIN
FIBRINOGEN GAMMA
CHAIN

(Homo
sapiens)
4 / 6 ILE A 154
LEU C 124
ILE B 179
TYR A 178
None
0.72A 5mvmB-3bvhA:
3.9
5mvmC-3bvhA:
3.9
5mvmB-3bvhA:
21.52
5mvmC-3bvhA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QJQ_A_K1SA304_0
(ADP-SUGAR
PYROPHOSPHATASE)
3bvh FIBRINOGEN GAMMA
CHAIN

(Homo
sapiens)
4 / 5 GLU C 183
TRP C 191
VAL C 193
LEU C 246
None
1.46A 5qjqA-3bvhC:
0.0
5qjqB-3bvhC:
0.0
5qjqA-3bvhC:
21.38
5qjqB-3bvhC:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QJQ_B_K1SB304_0
(ADP-SUGAR
PYROPHOSPHATASE)
3bvh FIBRINOGEN GAMMA
CHAIN

(Homo
sapiens)
4 / 5 TRP C 191
VAL C 193
LEU C 246
GLU C 183
None
1.46A 5qjqA-3bvhC:
0.0
5qjqB-3bvhC:
0.0
5qjqA-3bvhC:
21.38
5qjqB-3bvhC:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)
3bvh FIBRINOGEN ALPHA
CHAIN

(Homo
sapiens)
3 / 3 ARG A 162
ARG A 167
ARG A 171
None
0.88A 5vcgA-3bvhA:
undetectable
5vcgA-3bvhA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_H_BEZH201_0
(NS3 PROTEASE)
3bvh FIBRINOGEN GAMMA
CHAIN

(Homo
sapiens)
4 / 5 HIS C 343
SER C 332
TYR C 211
GLY C 333
None
1.37A 5yodH-3bvhC:
undetectable
5yodH-3bvhC:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
3bvh FIBRINOGEN BETA
CHAIN

(Homo
sapiens)
5 / 9 GLY B 414
TYR B 422
VAL B 435
ASP B 398
GLY B 399
None
1.36A 5zniA-3bvhB:
undetectable
5zniA-3bvhB:
16.48