SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bvq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 3bvq NOTI RESTRICTION
ENDONUCLEASE
(Nocardia
otitidiscaviarum) 		4 / 8 ALA A  47
LEU A  50
ALA A 111
THR A 114
 None
 0.93A 1ie4B-3bvqA:
undetectable
1ie4D-3bvqA:
undetectable		 1ie4B-3bvqA:
17.20
1ie4D-3bvqA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3bvq NOTI RESTRICTION
ENDONUCLEASE
(Nocardia
otitidiscaviarum) 		3 / 3 VAL A 326
ASP A 327
GLU A 296
 None
 0.62A 2qeuA-3bvqA:
undetectable		 2qeuA-3bvqA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3bvq NOTI RESTRICTION
ENDONUCLEASE
(Nocardia
otitidiscaviarum) 		3 / 3 VAL A 326
ASP A 327
GLU A 296
 None
 0.60A 2qeuC-3bvqA:
undetectable		 2qeuC-3bvqA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 3bvq NOTI RESTRICTION
ENDONUCLEASE
(Nocardia
otitidiscaviarum) 		5 / 12 ILE A 330
ILE A 148
VAL A 180
THR A 257
PHE A 246
 None
 1.13A 2qo5A-3bvqA:
undetectable		 2qo5A-3bvqA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3bvq NOTI RESTRICTION
ENDONUCLEASE
(Nocardia
otitidiscaviarum) 		4 / 8 THR A 114
ILE A 110
VAL A 134
GLY A 123
 None
 0.95A 4eq4B-3bvqA:
undetectable		 4eq4B-3bvqA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3bvq NOTI RESTRICTION
ENDONUCLEASE
(Nocardia
otitidiscaviarum) 		4 / 6 PHE A 301
ILE A 261
PHE A 303
PHE A  90
 None
 1.14A 4fgkA-3bvqA:
undetectable		 4fgkA-3bvqA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FH2_A_0RNA303_1
(BETA-LACTAMASE SHV-1)		 3bvq NOTI RESTRICTION
ENDONUCLEASE
(Nocardia
otitidiscaviarum) 		5 / 10 TYR A 101
SER A  95
VAL A 135
GLY A 179
ALA A 255
 None
 1.26A 4fh2A-3bvqA:
undetectable		 4fh2A-3bvqA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 3bvq NOTI RESTRICTION
ENDONUCLEASE
(Nocardia
otitidiscaviarum) 		4 / 8 PHE A  90
PHE A  44
TRP A 161
TYR A 137
 None
 1.22A 4v2zC-3bvqA:
undetectable		 4v2zC-3bvqA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 3bvq NOTI RESTRICTION
ENDONUCLEASE
(Nocardia
otitidiscaviarum) 		4 / 6 GLY A 228
GLU A 227
TYR A 192
ILE A  15
 None
 0.92A 5kmfA-3bvqA:
undetectable
5kmfC-3bvqA:
undetectable		 5kmfA-3bvqA:
19.69
5kmfC-3bvqA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 3bvq NOTI RESTRICTION
ENDONUCLEASE
(Nocardia
otitidiscaviarum) 		5 / 10 PRO A  43
ILE A 183
ALA A 260
PHE A  90
PRO A 313
 None
 1.32A 5m0oA-3bvqA:
undetectable		 5m0oA-3bvqA:
22.63