SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bw2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3bw2 2-NITROPROPANE
DIOXYGENASE
(Streptomyces
ansochromogenes) 		5 / 12 THR A 243
GLU A 245
LEU A 340
LEU A 336
GLY A 334
 None
 1.26A 1d4fD-3bw2A:
undetectable		 1d4fD-3bw2A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3bw2 2-NITROPROPANE
DIOXYGENASE
(Streptomyces
ansochromogenes) 		5 / 11 VAL A 212
VAL A 125
SER A 127
ALA A 168
LEU A   5
 None
 1.16A 1eqgB-3bw2A:
undetectable		 1eqgB-3bw2A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 3bw2 2-NITROPROPANE
DIOXYGENASE
(Streptomyces
ansochromogenes) 		5 / 11 ASP A 190
ARG A 268
GLY A 181
THR A 153
GLY A 193
 None
 1.25A 1jr1A-3bw2A:
22.0		 1jr1A-3bw2A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 3bw2 2-NITROPROPANE
DIOXYGENASE
(Streptomyces
ansochromogenes) 		5 / 11 ALA A 171
VAL A 203
PRO A  17
ALA A  16
VAL A  14
 None
None
FMN  A 370 (-4.4A)
FMN  A 370 (-3.5A)
None
 1.12A 1rv7A-3bw2A:
undetectable
1rv7B-3bw2A:
undetectable		 1rv7A-3bw2A:
14.48
1rv7B-3bw2A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 3bw2 2-NITROPROPANE
DIOXYGENASE
(Streptomyces
ansochromogenes) 		4 / 7 ARG A 329
ILE A  13
GLY A 237
PHE A 240
 None
None
FMN  A 370 (-3.2A)
None
 0.88A 2tsrA-3bw2A:
undetectable		 2tsrA-3bw2A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 3bw2 2-NITROPROPANE
DIOXYGENASE
(Streptomyces
ansochromogenes) 		5 / 11 LEU A 149
VAL A 161
LEU A   5
VAL A 207
ILE A 209
 None
 1.01A 2uxoB-3bw2A:
undetectable		 2uxoB-3bw2A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3bw2 2-NITROPROPANE
DIOXYGENASE
(Streptomyces
ansochromogenes) 		4 / 7 ILE A 223
GLY A 220
ARG A 219
PHE A 240
 None
 1.04A 2vctD-3bw2A:
undetectable		 2vctD-3bw2A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3bw2 2-NITROPROPANE
DIOXYGENASE
(Streptomyces
ansochromogenes) 		5 / 11 ALA A 164
ALA A 166
VAL A 125
LEU A   5
HIS A 183
 None
 1.24A 3bszE-3bw2A:
undetectable		 3bszE-3bw2A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 3bw2 2-NITROPROPANE
DIOXYGENASE
(Streptomyces
ansochromogenes) 		4 / 8 PRO A  12
ALA A 234
ALA A 213
ILE A 223
 None
 0.86A 3dtuC-3bw2A:
undetectable
3dtuD-3bw2A:
undetectable		 3dtuC-3bw2A:
22.68
3dtuD-3bw2A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3bw2 2-NITROPROPANE
DIOXYGENASE
(Streptomyces
ansochromogenes) 		5 / 12 VAL A  14
LEU A 200
ALA A 233
ALA A 168
ALA A 171
 None
 0.88A 3mdvB-3bw2A:
undetectable		 3mdvB-3bw2A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 3bw2 2-NITROPROPANE
DIOXYGENASE
(Streptomyces
ansochromogenes) 		4 / 6 ALA A 213
ILE A 217
LEU A 196
ALA A 229
 None
 0.77A 3r9sA-3bw2A:
undetectable		 3r9sA-3bw2A:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 3bw2 2-NITROPROPANE
DIOXYGENASE
(Streptomyces
ansochromogenes) 		4 / 6 ALA A 213
ILE A 217
LEU A 196
ALA A 229
 None
 0.82A 3r9sC-3bw2A:
undetectable		 3r9sC-3bw2A:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3bw2 2-NITROPROPANE
DIOXYGENASE
(Streptomyces
ansochromogenes) 		5 / 12 GLY A 195
ILE A 223
GLY A 216
ALA A 213
ALA A 234
 None
None
FMN  A 370 (-3.3A)
None
None
 1.08A 3sueA-3bw2A:
undetectable		 3sueA-3bw2A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 3bw2 2-NITROPROPANE
DIOXYGENASE
(Streptomyces
ansochromogenes) 		5 / 12 ARG A 281
PHE A 282
GLY A 287
ALA A  93
GLY A  91
 None
 1.22A 3v3oA-3bw2A:
undetectable		 3v3oA-3bw2A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 3bw2 2-NITROPROPANE
DIOXYGENASE
(Streptomyces
ansochromogenes) 		4 / 6 ALA A 318
ALA A 275
PRO A 274
THR A 267
 None
 0.99A 4dtzA-3bw2A:
undetectable		 4dtzA-3bw2A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3bw2 2-NITROPROPANE
DIOXYGENASE
(Streptomyces
ansochromogenes) 		4 / 8 GLY A 322
GLY A 215
LEU A 196
GLU A 175
 FMN  A 370 (-3.4A)
FMN  A 370 (-3.6A)
None
None
 0.92A 4fgzA-3bw2A:
undetectable		 4fgzA-3bw2A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3bw2 2-NITROPROPANE
DIOXYGENASE
(Streptomyces
ansochromogenes) 		4 / 8 GLY A 324
GLY A 215
LEU A 196
GLU A 175
 None
FMN  A 370 (-3.6A)
None
None
 0.89A 4fgzA-3bw2A:
undetectable		 4fgzA-3bw2A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3bw2 2-NITROPROPANE
DIOXYGENASE
(Streptomyces
ansochromogenes) 		4 / 8 GLY A 324
GLY A 215
LEU A 196
GLU A 175
 None
FMN  A 370 (-3.6A)
None
None
 0.91A 4fgzB-3bw2A:
undetectable		 4fgzB-3bw2A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 3bw2 2-NITROPROPANE
DIOXYGENASE
(Streptomyces
ansochromogenes) 		4 / 7 ALA A 239
GLU A 343
LEU A 340
LEU A 336
 None
 0.87A 4iomA-3bw2A:
undetectable		 4iomA-3bw2A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 3bw2 2-NITROPROPANE
DIOXYGENASE
(Streptomyces
ansochromogenes) 		5 / 10 ALA A 152
ILE A 170
GLY A 173
VAL A 211
VAL A 169
 None
 1.04A 4j5jB-3bw2A:
undetectable		 4j5jB-3bw2A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 3bw2 2-NITROPROPANE
DIOXYGENASE
(Streptomyces
ansochromogenes) 		4 / 8 ALA A 239
GLU A 343
LEU A 340
LEU A 336
 None
 0.86A 4jjkA-3bw2A:
undetectable		 4jjkA-3bw2A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 3bw2 2-NITROPROPANE
DIOXYGENASE
(Streptomyces
ansochromogenes) 		5 / 9 VAL A  31
ALA A  30
GLY A 237
PHE A 240
SER A  23
 None
None
FMN  A 370 (-3.2A)
None
None
 0.93A 4mmeB-3bw2A:
undetectable		 4mmeB-3bw2A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3bw2 2-NITROPROPANE
DIOXYGENASE
(Streptomyces
ansochromogenes) 		4 / 8 GLY A 322
ILE A 217
LEU A 196
GLU A 175
 FMN  A 370 (-3.4A)
None
None
None
 0.81A 4mwzB-3bw2A:
undetectable		 4mwzB-3bw2A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 3bw2 2-NITROPROPANE
DIOXYGENASE
(Streptomyces
ansochromogenes) 		5 / 12 PHE A  65
TYR A  51
VAL A  67
GLY A  66
LEU A 118
 None
 1.37A 4ot2A-3bw2A:
undetectable		 4ot2A-3bw2A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 3bw2 2-NITROPROPANE
DIOXYGENASE
(Streptomyces
ansochromogenes) 		5 / 12 LEU A 149
GLN A 235
LEU A  37
ILE A 138
PHE A 128
 None
FMN  A 370 (-4.0A)
None
None
None
 1.40A 4p6xI-3bw2A:
undetectable		 4p6xI-3bw2A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 3bw2 2-NITROPROPANE
DIOXYGENASE
(Streptomyces
ansochromogenes) 		4 / 7 VAL A  69
LEU A 141
VAL A 123
THR A 146
 None
 0.92A 5e4dA-3bw2A:
undetectable
5e4dB-3bw2A:
undetectable		 5e4dA-3bw2A:
17.56
5e4dB-3bw2A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3bw2 2-NITROPROPANE
DIOXYGENASE
(Streptomyces
ansochromogenes) 		4 / 5 VAL A 212
ASP A 232
PRO A 210
ALA A 233
 None
 0.96A 5otrA-3bw2A:
undetectable		 5otrA-3bw2A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 3bw2 2-NITROPROPANE
DIOXYGENASE
(Streptomyces
ansochromogenes) 		5 / 12 GLN A 180
GLY A 181
VAL A 132
ILE A 217
GLY A 177
 None
None
None
None
FMN  A 370 (-3.7A)
 1.17A 6c2mB-3bw2A:
undetectable		 6c2mB-3bw2A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 3bw2 2-NITROPROPANE
DIOXYGENASE
(Streptomyces
ansochromogenes) 		3 / 3 ARG A 273
ARG A 268
ASP A 185
 None
 0.98A 6d8pA-3bw2A:
undetectable		 6d8pA-3bw2A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3bw2 2-NITROPROPANE
DIOXYGENASE
(Streptomyces
ansochromogenes) 		4 / 8 ASP A 108
HIS A 298
ARG A 107
ASP A 296
 None
 1.24A 6mn4A-3bw2A:
undetectable		 6mn4A-3bw2A:
24.02