SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bwl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 3bwl SENSOR PROTEIN
(Haloarcula
marismortui) 		4 / 5 VAL A 486
GLN A 460
PHE A 448
ARG A 470
 None
 1.34A 3bjwB-3bwlA:
undetectable		 3bjwB-3bwlA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 3bwl SENSOR PROTEIN
(Haloarcula
marismortui) 		5 / 10 VAL A 486
VAL A 488
LEU A 490
SER A 505
GLY A 474
 None
None
I3A  A 601 ( 4.7A)
I3A  A 601 ( 4.7A)
None
 0.82A 3ls4H-3bwlA:
undetectable		 3ls4H-3bwlA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 3bwl SENSOR PROTEIN
(Haloarcula
marismortui) 		5 / 10 GLY A 481
SER A 482
LEU A 433
ARG A 478
TYR A 435
 None
 1.31A 5hwkA-3bwlA:
undetectable		 5hwkA-3bwlA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 3bwl SENSOR PROTEIN
(Haloarcula
marismortui) 		5 / 10 GLY A 481
SER A 482
LEU A 433
ARG A 478
TYR A 435
 None
 1.30A 5hwkB-3bwlA:
undetectable		 5hwkB-3bwlA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 3bwl SENSOR PROTEIN
(Haloarcula
marismortui) 		4 / 6 ARG A 388
GLU A 387
ALA A 386
LYS A 389
 None
 1.10A 6an0A-3bwlA:
undetectable		 6an0A-3bwlA:
16.71