SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bws'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 3bws PROTEIN LP49
(Leptospira
interrogans) 		4 / 6 ASN A 435
HIS A 136
GLY A 379
TYR A 381
 None
 0.91A 1c8lA-3bwsA:
undetectable		 1c8lA-3bwsA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 3bws PROTEIN LP49
(Leptospira
interrogans) 		4 / 6 ASN A 435
HIS A 136
GLY A 379
TYR A 381
 None
 0.90A 1gfzA-3bwsA:
undetectable		 1gfzA-3bwsA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3bws PROTEIN LP49
(Leptospira
interrogans) 		4 / 6 ASN A 435
HIS A 136
GLY A 379
TYR A 381
 None
 0.91A 1l5qA-3bwsA:
undetectable		 1l5qA-3bwsA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3bws PROTEIN LP49
(Leptospira
interrogans) 		4 / 6 ASN A 435
HIS A 136
GLY A 379
TYR A 381
 None
 0.92A 1l5qB-3bwsA:
undetectable		 1l5qB-3bwsA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3bws PROTEIN LP49
(Leptospira
interrogans) 		4 / 6 ASN A 435
HIS A 136
GLY A 379
TYR A 381
 None
 0.91A 1l7xA-3bwsA:
undetectable		 1l7xA-3bwsA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3bws PROTEIN LP49
(Leptospira
interrogans) 		4 / 6 ASN A 435
HIS A 136
GLY A 379
TYR A 381
 None
 0.91A 1l7xB-3bwsA:
undetectable		 1l7xB-3bwsA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3bws PROTEIN LP49
(Leptospira
interrogans) 		5 / 12 ILE A 322
LEU A 308
VAL A 342
ILE A 340
ILE A 310
 None
 0.99A 1oipA-3bwsA:
undetectable		 1oipA-3bwsA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3bws PROTEIN LP49
(Leptospira
interrogans) 		3 / 3 LEU A 283
HIS A 330
ILE A 239
 None
 0.61A 1s9pB-3bwsA:
undetectable		 1s9pB-3bwsA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 3bws PROTEIN LP49
(Leptospira
interrogans) 		4 / 6 LYS A  76
LEU A  78
LEU A  86
SER A  57
 None
 1.15A 1tyrA-3bwsA:
undetectable		 1tyrA-3bwsA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 3bws PROTEIN LP49
(Leptospira
interrogans) 		4 / 6 LYS A  76
LEU A  78
LEU A  86
SER A  57
 None
 0.98A 1tz8C-3bwsA:
undetectable
1tz8D-3bwsA:
3.9		 1tz8C-3bwsA:
16.97
1tz8D-3bwsA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_D_DESD128_1
(TRANSTHYRETIN)		 3bws PROTEIN LP49
(Leptospira
interrogans) 		4 / 4 LYS A  76
LEU A  78
LEU A  86
SER A  57
 None
 1.34A 1tz8D-3bwsA:
3.9		 1tz8D-3bwsA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE509_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3bws PROTEIN LP49
(Leptospira
interrogans) 		4 / 6 ASP A 258
GLU A 269
ARG A 271
LYS A 272
 None
 1.50A 1yc2A-3bwsA:
undetectable
1yc2B-3bwsA:
undetectable
1yc2E-3bwsA:
undetectable		 1yc2A-3bwsA:
20.50
1yc2B-3bwsA:
20.50
1yc2E-3bwsA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 3bws PROTEIN LP49
(Leptospira
interrogans) 		4 / 6 LYS A  76
LEU A  78
LEU A  86
SER A  57
 None
 1.07A 3cfqA-3bwsA:
undetectable		 3cfqA-3bwsA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3bws PROTEIN LP49
(Leptospira
interrogans) 		4 / 6 ASN A 435
HIS A 136
GLY A 379
TYR A 381
 None
 0.88A 3dd1A-3bwsA:
undetectable		 3dd1A-3bwsA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3bws PROTEIN LP49
(Leptospira
interrogans) 		4 / 6 ASN A 435
HIS A 136
GLY A 379
TYR A 381
 None
 0.91A 3dd1B-3bwsA:
undetectable		 3dd1B-3bwsA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3bws PROTEIN LP49
(Leptospira
interrogans) 		4 / 6 ASN A 435
HIS A 136
GLY A 379
TYR A 381
 None
 0.91A 3ddsA-3bwsA:
undetectable		 3ddsA-3bwsA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3bws PROTEIN LP49
(Leptospira
interrogans) 		4 / 6 ASN A 435
HIS A 136
GLY A 379
TYR A 381
 None
 0.91A 3ddsB-3bwsA:
undetectable		 3ddsB-3bwsA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3bws PROTEIN LP49
(Leptospira
interrogans) 		4 / 6 ASN A 435
HIS A 136
GLY A 379
TYR A 381
 None
 0.92A 3ddwA-3bwsA:
undetectable		 3ddwA-3bwsA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3bws PROTEIN LP49
(Leptospira
interrogans) 		4 / 6 ASN A 435
HIS A 136
GLY A 379
TYR A 381
 None
 0.92A 3ddwB-3bwsA:
undetectable		 3ddwB-3bwsA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 3bws PROTEIN LP49
(Leptospira
interrogans) 		3 / 3 ASP A 434
PHE A 153
SER A 376
 None
 0.78A 3i5uB-3bwsA:
undetectable		 3i5uB-3bwsA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3bws PROTEIN LP49
(Leptospira
interrogans) 		5 / 12 GLY A 177
SER A 176
ILE A 448
LEU A 172
ARG A 158
 None
 1.30A 3iv6B-3bwsA:
undetectable		 3iv6B-3bwsA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 3bws PROTEIN LP49
(Leptospira
interrogans) 		5 / 11 ILE A 239
PRO A 279
ILE A 293
LEU A 291
ILE A 259
 None
 1.04A 4dt8A-3bwsA:
2.4		 4dt8A-3bwsA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 3bws PROTEIN LP49
(Leptospira
interrogans) 		5 / 10 ILE A 239
PRO A 279
ILE A 293
LEU A 291
ILE A 259
 None
 1.02A 4dtaA-3bwsA:
2.3		 4dtaA-3bwsA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 3bws PROTEIN LP49
(Leptospira
interrogans) 		4 / 8 ILE A 331
LYS A 369
ILE A 350
GLY A 326
 None
 0.89A 4hdlA-3bwsA:
undetectable		 4hdlA-3bwsA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3bws PROTEIN LP49
(Leptospira
interrogans) 		4 / 4 LEU A 163
LEU A 182
GLN A 212
GLU A 196
 None
 1.24A 4i41A-3bwsA:
undetectable		 4i41A-3bwsA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 3bws PROTEIN LP49
(Leptospira
interrogans) 		4 / 6 LYS A  76
LEU A  78
LEU A  86
SER A  57
 None
 1.04A 4i89A-3bwsA:
undetectable		 4i89A-3bwsA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 3bws PROTEIN LP49
(Leptospira
interrogans) 		4 / 7 LYS A  76
LEU A  78
LEU A  86
SER A  57
 None
 1.04A 4ikkA-3bwsA:
2.6
4ikkB-3bwsA:
undetectable		 4ikkA-3bwsA:
16.97
4ikkB-3bwsA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 3bws PROTEIN LP49
(Leptospira
interrogans) 		5 / 11 ASN A 371
SER A 343
VAL A 332
ILE A 331
LEU A 241
 None
 1.40A 4k37B-3bwsA:
undetectable		 4k37B-3bwsA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3bws PROTEIN LP49
(Leptospira
interrogans) 		5 / 12 LEU A 282
LEU A 291
ILE A 293
GLU A 302
VAL A 261
 None
 0.90A 4y0sA-3bwsA:
undetectable		 4y0sA-3bwsA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 3bws PROTEIN LP49
(Leptospira
interrogans) 		5 / 12 GLY A 288
GLU A 202
TYR A 242
TYR A 250
LEU A 241
 None
 1.33A 5czyA-3bwsA:
undetectable		 5czyA-3bwsA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 3bws PROTEIN LP49
(Leptospira
interrogans) 		5 / 11 ASP A 258
THR A 273
VAL A 261
VAL A 249
LEU A 232
 None
 1.34A 5jkwA-3bwsA:
undetectable		 5jkwA-3bwsA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 3bws PROTEIN LP49
(Leptospira
interrogans) 		5 / 10 VAL A 195
LEU A 232
THR A 273
GLY A 281
LEU A 282
 None
 1.22A 5m5cE-3bwsA:
undetectable		 5m5cE-3bwsA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 3bws PROTEIN LP49
(Leptospira
interrogans) 		4 / 5 LEU A 282
CYH A 251
LEU A 232
ASP A 258
 None
 1.45A 5mafA-3bwsA:
3.0		 5mafA-3bwsA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 3bws PROTEIN LP49
(Leptospira
interrogans) 		5 / 9 LEU A 429
VAL A 431
LEU A 438
ILE A 409
PRO A 377
 None
 1.36A 5og9A-3bwsA:
undetectable		 5og9A-3bwsA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 3bws PROTEIN LP49
(Leptospira
interrogans) 		4 / 8 HIS A 446
GLY A 145
GLY A 168
GLU A 165
 None
 0.87A 6mdqA-3bwsA:
undetectable		 6mdqA-3bwsA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3bws PROTEIN LP49
(Leptospira
interrogans) 		3 / 3 ARG A 449
LEU A 126
PHE A  56
 None
 0.50A 6nknP-3bwsA:
undetectable		 6nknP-3bwsA:
19.91