SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bwt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3bwt PROTEIN PUF4
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 657
VAL A 689
SER A 644
ILE A 643
VAL A 669
 None
 1.20A 1z9hD-3bwtA:
3.1		 1z9hD-3bwtA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 3bwt PROTEIN PUF4
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 806
VAL A 840
MET A 815
ILE A 816
 None
 0.83A 2piwA-3bwtA:
undetectable		 2piwA-3bwtA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 3bwt PROTEIN PUF4
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 716
LEU A 694
PHE A 706
LEU A 745
THR A 677
 None
 0.97A 2w3bA-3bwtA:
undetectable		 2w3bA-3bwtA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 3bwt PROTEIN PUF4
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 716
LEU A 694
PHE A 706
LEU A 745
THR A 677
 None
 0.93A 2w3bB-3bwtA:
undetectable		 2w3bB-3bwtA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 3bwt PROTEIN PUF4
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 716
LEU A 694
PHE A 706
LEU A 745
THR A 677
 None
 0.92A 2w3mA-3bwtA:
undetectable		 2w3mA-3bwtA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 3bwt PROTEIN PUF4
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 716
LEU A 694
PHE A 706
LEU A 745
THR A 677
 None
 1.00A 2w3mB-3bwtA:
undetectable		 2w3mB-3bwtA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3bwt PROTEIN PUF4
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 880
SER A 793
ALA A 789
ILE A 802
LEU A 806
 None
 1.31A 3adsB-3bwtA:
undetectable		 3adsB-3bwtA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 3bwt PROTEIN PUF4
(Saccharomyces
cerevisiae) 		5 / 9 THR A 874
LEU A 841
SER A 860
ILE A 828
GLY A 869
 None
 1.16A 3cv9A-3bwtA:
undetectable		 3cv9A-3bwtA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3bwt PROTEIN PUF4
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 782
ILE A 802
ILE A 781
LEU A 784
 None
 0.80A 3hegA-3bwtA:
undetectable		 3hegA-3bwtA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 3bwt PROTEIN PUF4
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 775
VAL A 811
THR A 778
ILE A 781
 None
 0.81A 3p4wC-3bwtA:
undetectable		 3p4wC-3bwtA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3bwt PROTEIN PUF4
(Saccharomyces
cerevisiae) 		4 / 8 PRO A 865
LEU A 832
LEU A 841
ILE A 862
 None
 0.92A 3u5kD-3bwtA:
undetectable		 3u5kD-3bwtA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 3bwt PROTEIN PUF4
(Saccharomyces
cerevisiae) 		5 / 8 LEU A 632
ILE A 617
ASN A 614
GLY A 649
ILE A 643
 None
 1.30A 3wxoA-3bwtA:
undetectable		 3wxoA-3bwtA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 3bwt PROTEIN PUF4
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 687
VAL A 678
HIS A 719
ILE A 716
 None
 0.98A 4eyzA-3bwtA:
undetectable		 4eyzA-3bwtA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 3bwt PROTEIN PUF4
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 687
VAL A 678
HIS A 719
ILE A 716
 None
 0.99A 4eyzB-3bwtA:
undetectable		 4eyzB-3bwtA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 3bwt PROTEIN PUF4
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 621
ALA A 652
LEU A 656
SER A 644
 None
 1.13A 4iklA-3bwtA:
undetectable
4iklB-3bwtA:
undetectable		 4iklA-3bwtA:
18.27
4iklB-3bwtA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 3bwt PROTEIN PUF4
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 716
LEU A 694
PHE A 706
LEU A 745
THR A 677
 None
 0.90A 4kebB-3bwtA:
undetectable		 4kebB-3bwtA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 3bwt PROTEIN PUF4
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 716
LEU A 694
PHE A 706
LEU A 745
THR A 677
 None
 0.89A 4kfjB-3bwtA:
undetectable		 4kfjB-3bwtA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3bwt PROTEIN PUF4
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 716
LEU A 694
PHE A 706
LEU A 745
THR A 677
 None
 0.89A 4m6kA-3bwtA:
undetectable		 4m6kA-3bwtA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3bwt PROTEIN PUF4
(Saccharomyces
cerevisiae) 		5 / 8 LEU A 832
LEU A 841
LEU A 845
LEU A 884
LEU A 867
 None
 1.06A 4z90A-3bwtA:
undetectable
4z90B-3bwtA:
undetectable
4z90C-3bwtA:
undetectable
4z90D-3bwtA:
undetectable
4z90E-3bwtA:
undetectable		 4z90A-3bwtA:
21.01
4z90B-3bwtA:
21.01
4z90C-3bwtA:
21.01
4z90D-3bwtA:
21.01
4z90E-3bwtA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3bwt PROTEIN PUF4
(Saccharomyces
cerevisiae) 		5 / 8 LEU A 845
LEU A 884
LEU A 867
LEU A 832
LEU A 841
 None
 1.05A 4z90A-3bwtA:
undetectable
4z90B-3bwtA:
undetectable
4z90C-3bwtA:
undetectable
4z90D-3bwtA:
undetectable
4z90E-3bwtA:
undetectable		 4z90A-3bwtA:
21.01
4z90B-3bwtA:
21.01
4z90C-3bwtA:
21.01
4z90D-3bwtA:
21.01
4z90E-3bwtA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3bwt PROTEIN PUF4
(Saccharomyces
cerevisiae) 		5 / 8 LEU A 867
LEU A 832
LEU A 841
LEU A 845
LEU A 884
 None
 1.03A 4z90A-3bwtA:
undetectable
4z90B-3bwtA:
undetectable
4z90C-3bwtA:
undetectable
4z90D-3bwtA:
undetectable
4z90E-3bwtA:
undetectable		 4z90A-3bwtA:
21.01
4z90B-3bwtA:
21.01
4z90C-3bwtA:
21.01
4z90D-3bwtA:
21.01
4z90E-3bwtA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3bwt PROTEIN PUF4
(Saccharomyces
cerevisiae) 		5 / 8 LEU A 884
LEU A 867
LEU A 832
LEU A 841
LEU A 845
 None
 1.04A 4z90A-3bwtA:
undetectable
4z90B-3bwtA:
undetectable
4z90C-3bwtA:
undetectable
4z90D-3bwtA:
undetectable
4z90E-3bwtA:
undetectable		 4z90A-3bwtA:
21.01
4z90B-3bwtA:
21.01
4z90C-3bwtA:
21.01
4z90D-3bwtA:
21.01
4z90E-3bwtA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 3bwt PROTEIN PUF4
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 669
GLN A 654
CYH A 693
 None
 0.69A 5icxA-3bwtA:
undetectable
5icxE-3bwtA:
undetectable		 5icxA-3bwtA:
20.85
5icxE-3bwtA:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 3bwt PROTEIN PUF4
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 669
GLN A 654
CYH A 693
 None
 0.47A 5icxC-3bwtA:
undetectable
5icxF-3bwtA:
undetectable		 5icxC-3bwtA:
20.85
5icxF-3bwtA:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 3bwt PROTEIN PUF4
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 620
LEU A 571
GLY A 577
PHE A 580
ILE A 568
 None
 1.13A 5j7wC-3bwtA:
undetectable		 5j7wC-3bwtA:
23.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 3bwt PROTEIN PUF4
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 795
LYS A 796
PHE A 797
 None
 1.43A 5klaA-3bwtA:
33.0		 5klaA-3bwtA:
32.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 3bwt PROTEIN PUF4
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 702
ASN A 740
GLN A 703
ASP A 743
 None
 1.45A 5kpcA-3bwtA:
undetectable		 5kpcA-3bwtA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 3bwt PROTEIN PUF4
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 775
VAL A 811
THR A 778
ILE A 781
 None
 0.88A 5mzrE-3bwtA:
undetectable		 5mzrE-3bwtA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 3bwt PROTEIN PUF4
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 722
ASN A 759
GLN A 763
LEU A 752
LEU A 745
 None
 1.22A 5nwwA-3bwtA:
undetectable		 5nwwA-3bwtA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3bwt PROTEIN PUF4
(Saccharomyces
cerevisiae) 		4 / 7 THR A 650
GLN A 691
ILE A 690
GLY A 686
 None
 0.87A 5nzyA-3bwtA:
undetectable		 5nzyA-3bwtA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3bwt PROTEIN PUF4
(Saccharomyces
cerevisiae) 		5 / 12 GLN A 618
LEU A 621
ASN A 646
ILE A 643
HIS A 569
 None
 1.36A 5uhbC-3bwtA:
0.0		 5uhbC-3bwtA:
14.52