SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bww'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3bww PROTEIN OF UNKNOWN
FUNCTION
DUF692/COG3220
(Histophilus
somni) 		3 / 3 GLU A 138
HIS A  94
HIS A  59
 FE  A 307 (-2.5A)
FE  A 307 ( 3.2A)
FE  A 307 (-3.4A)
 0.65A 1oe2A-3bwwA:
undetectable		 1oe2A-3bwwA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3bww PROTEIN OF UNKNOWN
FUNCTION
DUF692/COG3220
(Histophilus
somni) 		4 / 7 PHE A  91
ILE A  37
PRO A  33
GLU A  34
 None
 1.07A 1oniA-3bwwA:
undetectable
1oniB-3bwwA:
undetectable		 1oniA-3bwwA:
20.07
1oniB-3bwwA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_G_BEZG513_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3bww PROTEIN OF UNKNOWN
FUNCTION
DUF692/COG3220
(Histophilus
somni) 		4 / 5 PHE A  91
ILE A  37
PRO A  33
GLU A  34
 None
 1.10A 1oniG-3bwwA:
undetectable
1oniH-3bwwA:
undetectable		 1oniG-3bwwA:
20.07
1oniH-3bwwA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3bww PROTEIN OF UNKNOWN
FUNCTION
DUF692/COG3220
(Histophilus
somni) 		5 / 12 TYR A 201
HIS A 203
ILE A  56
LEU A  61
ILE A  79
 None
FE  A 308 (-3.4A)
None
None
None
 1.15A 2h42B-3bwwA:
undetectable		 2h42B-3bwwA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3bww PROTEIN OF UNKNOWN
FUNCTION
DUF692/COG3220
(Histophilus
somni) 		4 / 6 PHE A  91
ASN A 200
ASN A 173
LEU A 254
 None
 1.31A 2nyrA-3bwwA:
undetectable		 2nyrA-3bwwA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 3bww PROTEIN OF UNKNOWN
FUNCTION
DUF692/COG3220
(Histophilus
somni) 		5 / 12 PHE A 112
SER A 149
THR A 150
ALA A 116
ILE A 160
 None
 1.29A 3lcvB-3bwwA:
undetectable		 3lcvB-3bwwA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZS3_A_ACTA1224_0
(THAUMATIN-LIKE
PROTEIN)		 3bww PROTEIN OF UNKNOWN
FUNCTION
DUF692/COG3220
(Histophilus
somni) 		4 / 5 SER A  92
GLU A 138
TYR A 201
ASP A 171
 None
FE  A 307 (-2.5A)
None
FE  A 308 ( 3.2A)
 1.49A 3zs3A-3bwwA:
undetectable		 3zs3A-3bwwA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 3bww PROTEIN OF UNKNOWN
FUNCTION
DUF692/COG3220
(Histophilus
somni) 		4 / 5 LEU A  61
HIS A 169
GLU A 138
HIS A 203
 None
None
FE  A 307 (-2.5A)
FE  A 308 (-3.4A)
 1.09A 4a7bB-3bwwA:
undetectable		 4a7bB-3bwwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 3bww PROTEIN OF UNKNOWN
FUNCTION
DUF692/COG3220
(Histophilus
somni) 		4 / 5 ILE A  31
ALA A  51
MET A  29
ARG A   2
 None
 1.19A 4ac9B-3bwwA:
2.7
4ac9C-3bwwA:
2.8		 4ac9B-3bwwA:
21.13
4ac9C-3bwwA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3bww PROTEIN OF UNKNOWN
FUNCTION
DUF692/COG3220
(Histophilus
somni) 		4 / 5 ILE A  31
ALA A  51
MET A  29
ARG A   2
 None
 1.19A 4acaB-3bwwA:
2.6
4acaC-3bwwA:
2.9		 4acaB-3bwwA:
21.13
4acaC-3bwwA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3bww PROTEIN OF UNKNOWN
FUNCTION
DUF692/COG3220
(Histophilus
somni) 		3 / 3 HIS A  59
GLU A 270
ASN A 174
 FE  A 307 (-3.4A)
FE  A 308 ( 2.5A)
CAC  A 309 (-3.2A)
 0.72A 4bupB-3bwwA:
undetectable		 4bupB-3bwwA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3bww PROTEIN OF UNKNOWN
FUNCTION
DUF692/COG3220
(Histophilus
somni) 		5 / 12 LEU A 196
LEU A 261
LEU A 301
ARG A 260
ILE A 191
 None
 1.04A 4f4dA-3bwwA:
undetectable		 4f4dA-3bwwA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3bww PROTEIN OF UNKNOWN
FUNCTION
DUF692/COG3220
(Histophilus
somni) 		3 / 3 GLU A 255
TYR A 256
ARG A 260
 None
 0.73A 5uunA-3bwwA:
undetectable		 5uunA-3bwwA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3bww PROTEIN OF UNKNOWN
FUNCTION
DUF692/COG3220
(Histophilus
somni) 		3 / 3 GLU A 255
TYR A 256
ARG A 260
 None
 0.71A 5uunB-3bwwA:
undetectable		 5uunB-3bwwA:
20.86