SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bxh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 3bxh CENTRAL GLYCOLYTIC
GENE REGULATOR
(Bacillus
subtilis) 		5 / 11 ALA A 313
GLU A 315
PHE A 318
LEU A 107
THR A 268
 None
 1.28A 1jomA-3bxhA:
undetectable		 1jomA-3bxhA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3bxh CENTRAL GLYCOLYTIC
GENE REGULATOR
(Bacillus
subtilis) 		4 / 4 ALA A 244
VAL A 267
ALA A 266
HIS A 283
 None
 1.14A 1q23A-3bxhA:
undetectable		 1q23A-3bxhA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 3bxh CENTRAL GLYCOLYTIC
GENE REGULATOR
(Bacillus
subtilis) 		4 / 6 ILE A 314
ALA A 305
THR A 152
ALA A 131
 None
None
F6P  A 401 (-3.5A)
None
 0.83A 1w0gA-3bxhA:
undetectable		 1w0gA-3bxhA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 3bxh CENTRAL GLYCOLYTIC
GENE REGULATOR
(Bacillus
subtilis) 		4 / 7 GLU A 330
TRP A 122
PRO A 121
GLY A 331
 None
 1.30A 2hs1B-3bxhA:
undetectable		 2hs1B-3bxhA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 3bxh CENTRAL GLYCOLYTIC
GENE REGULATOR
(Bacillus
subtilis) 		3 / 3 ASP A 278
THR A 100
GLU A 315
 None
 0.76A 2zifB-3bxhA:
undetectable		 2zifB-3bxhA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 3bxh CENTRAL GLYCOLYTIC
GENE REGULATOR
(Bacillus
subtilis) 		4 / 8 LEU A 178
ARG A 251
TYR A 273
GLU A 269
 SCN  A   1 (-4.4A)
F6P  A 401 (-3.7A)
None
F6P  A 401 (-2.9A)
 1.33A 3zmdA-3bxhA:
undetectable
3zmdB-3bxhA:
undetectable		 3zmdA-3bxhA:
18.53
3zmdB-3bxhA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 3bxh CENTRAL GLYCOLYTIC
GENE REGULATOR
(Bacillus
subtilis) 		5 / 12 TYR A 215
GLY A 289
GLY A 176
ILE A 219
VAL A 206
 None
 1.08A 4a6dA-3bxhA:
undetectable		 4a6dA-3bxhA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_A_LURA201_1
(TRANSTHYRETIN)		 3bxh CENTRAL GLYCOLYTIC
GENE REGULATOR
(Bacillus
subtilis) 		4 / 4 LYS A 102
LEU A  94
ALA A 110
VAL A 325
 None
 1.28A 4ik6A-3bxhA:
undetectable		 4ik6A-3bxhA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3bxh CENTRAL GLYCOLYTIC
GENE REGULATOR
(Bacillus
subtilis) 		4 / 8 ASP A 329
ALA A 305
SER A 117
ASP A 118
 None
 0.99A 4k0bB-3bxhA:
undetectable		 4k0bB-3bxhA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3bxh CENTRAL GLYCOLYTIC
GENE REGULATOR
(Bacillus
subtilis) 		4 / 8 ASP A 329
ALA A 305
SER A 117
ASP A 118
 None
 1.00A 4l7iB-3bxhA:
undetectable		 4l7iB-3bxhA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3bxh CENTRAL GLYCOLYTIC
GENE REGULATOR
(Bacillus
subtilis) 		4 / 5 GLY A 115
ASP A 329
GLU A  98
VAL A 325
 None
 1.17A 4nkvD-3bxhA:
undetectable		 4nkvD-3bxhA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 3bxh CENTRAL GLYCOLYTIC
GENE REGULATOR
(Bacillus
subtilis) 		4 / 7 GLU A 180
THR A 151
GLY A 150
THR A 152
 F6P  A 401 (-3.3A)
F6P  A 401 (-2.9A)
F6P  A 401 (-3.5A)
F6P  A 401 (-3.5A)
 0.90A 4qwpB-3bxhA:
undetectable		 4qwpB-3bxhA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 3bxh CENTRAL GLYCOLYTIC
GENE REGULATOR
(Bacillus
subtilis) 		4 / 8 LEU A 101
GLU A  98
MET A 127
ALA A 131
 None
 0.88A 4rjdA-3bxhA:
undetectable
4rjdB-3bxhA:
undetectable		 4rjdA-3bxhA:
16.17
4rjdB-3bxhA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3bxh CENTRAL GLYCOLYTIC
GENE REGULATOR
(Bacillus
subtilis) 		5 / 12 SER A 309
GLN A 119
ALA A 305
GLY A 306
THR A 152
 None
None
None
None
F6P  A 401 (-3.5A)
 1.29A 5l5zH-3bxhA:
undetectable
5l5zI-3bxhA:
undetectable		 5l5zH-3bxhA:
21.09
5l5zI-3bxhA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3bxh CENTRAL GLYCOLYTIC
GENE REGULATOR
(Bacillus
subtilis) 		5 / 12 SER A 309
GLN A 119
ALA A 305
GLY A 306
THR A 152
 None
None
None
None
F6P  A 401 (-3.5A)
 1.29A 5l5zV-3bxhA:
undetectable
5l5zW-3bxhA:
undetectable		 5l5zV-3bxhA:
21.09
5l5zW-3bxhA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 3bxh CENTRAL GLYCOLYTIC
GENE REGULATOR
(Bacillus
subtilis) 		5 / 9 ALA A 313
ALA A 305
GLY A 242
ALA A 303
GLY A 240
 None
None
F6P  A 401 (-3.5A)
None
F6P  A 401 ( 4.1A)
 1.10A 6bklE-3bxhA:
undetectable
6bklF-3bxhA:
undetectable
6bklG-3bxhA:
undetectable
6bklH-3bxhA:
undetectable		 6bklE-3bxhA:
7.06
6bklF-3bxhA:
7.06
6bklG-3bxhA:
7.06
6bklH-3bxhA:
7.06