SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bxw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 SER B 356
VAL B 355
GLY B 276
ASN B 278
TYR B 239
 None
 1.49A 1a27A-3bxwB:
undetectable		 1a27A-3bxwB:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 10 GLY B 363
ARG B  26
LEU B  28
GLU B  41
HIS B  42
 None
 1.38A 1cmcA-3bxwB:
undetectable
1cmcB-3bxwB:
undetectable		 1cmcA-3bxwB:
15.57
1cmcB-3bxwB:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 10 ARG B  26
LEU B  28
GLU B  41
HIS B  42
GLY B 363
 None
 1.40A 1cmcA-3bxwB:
undetectable
1cmcB-3bxwB:
undetectable		 1cmcA-3bxwB:
15.57
1cmcB-3bxwB:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_B_SAMB400_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 9 ARG B  26
LEU B  28
GLU B  41
HIS B  42
GLY B 363
 None
 1.34A 1mjlA-3bxwB:
undetectable
1mjlB-3bxwB:
undetectable		 1mjlA-3bxwB:
14.51
1mjlB-3bxwB:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 11 GLY B 363
ARG B  26
LEU B  28
GLU B  41
HIS B  42
 None
 1.41A 1mjqA-3bxwB:
undetectable
1mjqB-3bxwB:
undetectable		 1mjqA-3bxwB:
14.51
1mjqB-3bxwB:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_H_SAMH200_0
(METHIONINE REPRESSOR)		 3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 10 GLY B 363
ARG B  26
LEU B  28
GLU B  41
HIS B  42
 None
 1.41A 1mjqG-3bxwB:
undetectable
1mjqH-3bxwB:
undetectable		 1mjqG-3bxwB:
14.51
1mjqH-3bxwB:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 6 HIS B 306
GLU B 292
PRO B 293
VAL B 333
 None
 1.18A 1q13A-3bxwB:
9.0		 1q13A-3bxwB:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 6 VAL B 101
THR B 102
GLU B 131
LEU B  91
 None
 1.03A 1s8fB-3bxwB:
undetectable		 1s8fB-3bxwB:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2433_1
(CHITINASE)		 3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 9 GLU B 170
MET B 237
TYR B 239
TYR B 280
TRP B 358
 None
 1.12A 2a3aB-3bxwB:
26.6		 2a3aB-3bxwB:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU B 231
GLY B 233
LEU B 202
LEU B 203
LEU B 194
 None
 1.06A 2f8dB-3bxwB:
undetectable		 2f8dB-3bxwB:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 HIS B 163
LEU B 199
GLY B 166
PHE B 164
ALA B 193
 None
 1.16A 2kceB-3bxwB:
undetectable		 2kceB-3bxwB:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 SER B  68
TYR B  71
HIS B  69
 None
 0.78A 2r2vD-3bxwB:
undetectable		 2r2vD-3bxwB:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 9 LEU B 277
ILE B  84
GLY B  78
VAL B 355
ILE B 357
 None
 1.16A 2r5qA-3bxwB:
undetectable		 2r5qA-3bxwB:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 9 LEU B 277
ILE B  84
GLY B  78
VAL B 355
ILE B 357
 None
 1.17A 2r5qC-3bxwB:
undetectable		 2r5qC-3bxwB:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 10 PHE B  81
ILE B 273
LEU B 370
ILE B 205
GLY B  61
 None
 1.36A 2v0mA-3bxwB:
undetectable		 2v0mA-3bxwB:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 PHE B 279
SER B 340
LEU B 338
 None
 0.81A 2w1bA-3bxwB:
undetectable		 2w1bA-3bxwB:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 8 GLN B 342
LEU B 277
LEU B 370
ARG B 349
 None
 0.95A 2xn3A-3bxwB:
undetectable
2xn3B-3bxwB:
undetectable		 2xn3A-3bxwB:
21.07
2xn3B-3bxwB:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G6M_A_CFFA1_1
(CHITINASE)		 3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		6 / 11 TYR B  62
GLU B 170
MET B 237
TYR B 239
TYR B 280
TRP B 358
 None
 0.99A 3g6mA-3bxwB:
26.8		 3g6mA-3bxwB:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ASP B 369
ARG B  26
ASP B  52
 None
 0.81A 4fp9A-3bxwB:
undetectable		 4fp9A-3bxwB:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ASP B 283
VAL B 333
SER B 242
GLY B 248
GLN B 246
 None
 1.37A 4pevA-3bxwB:
undetectable		 4pevA-3bxwB:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL B 204
LEU B 351
LEU B 263
LEU B 275
ALA B 208
 None
SO4  B 372 (-4.5A)
None
None
None
 1.25A 4x1kA-3bxwB:
3.5
4x1kB-3bxwB:
4.1		 4x1kA-3bxwB:
22.63
4x1kB-3bxwB:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLY B 361
LEU B  60
GLY B 166
PHE B  81
THR B  64
 None
 1.12A 4ze1A-3bxwB:
undetectable		 4ze1A-3bxwB:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 8 SER B 242
GLY B 212
THR B 238
PHE B 334
 None
 0.86A 5flcB-3bxwB:
undetectable		 5flcB-3bxwB:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 8 SER B 242
GLY B 212
THR B 238
PHE B 334
 None
 0.85A 5flcF-3bxwB:
undetectable		 5flcF-3bxwB:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 7 LEU B 360
VAL B 204
TYR B 239
SER B 235
 None
 1.21A 5umwA-3bxwB:
undetectable
5umwF-3bxwB:
undetectable		 5umwA-3bxwB:
15.65
5umwF-3bxwB:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 6 PHE B  55
LEU B 345
ALA B 348
GLN B  24
 None
 1.04A 6b89B-3bxwB:
1.5		 6b89B-3bxwB:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 9 PHE B  99
HIS B 189
LEU B  89
VAL B 125
SER B  85
 None
 1.42A 6c2mD-3bxwB:
undetectable		 6c2mD-3bxwB:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 8 ASP B 305
HIS B  42
ARG B 307
HIS B 306
 None
 1.23A 6mn4C-3bxwB:
undetectable		 6mn4C-3bxwB:
23.18