SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3by5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 3by5 COBALAMIN
BIOSYNTHESIS PROTEIN
(Agrobacterium
fabrum) 		5 / 12 VAL A  28
LEU A  54
GLY A  12
ALA A  11
LEU A  61
 None
 1.08A 1r9oA-3by5A:
undetectable		 1r9oA-3by5A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3by5 COBALAMIN
BIOSYNTHESIS PROTEIN
(Agrobacterium
fabrum) 		4 / 7 PRO A  46
ALA A  69
LEU A  73
ALA A 103
 None
 1.08A 2vcvA-3by5A:
undetectable		 2vcvA-3by5A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1437_1
(ORF12)		 3by5 COBALAMIN
BIOSYNTHESIS PROTEIN
(Agrobacterium
fabrum) 		5 / 11 SER A  84
ALA A 107
GLY A 108
ALA A 109
ARG A  72
 None
 1.40A 2xh9A-3by5A:
undetectable		 2xh9A-3by5A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 3by5 COBALAMIN
BIOSYNTHESIS PROTEIN
(Agrobacterium
fabrum) 		4 / 6 GLY A  12
ARG A 110
ILE A 125
LEU A  42
 None
 1.12A 4ac9C-3by5A:
undetectable		 4ac9C-3by5A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3by5 COBALAMIN
BIOSYNTHESIS PROTEIN
(Agrobacterium
fabrum) 		4 / 6 GLY A  12
ARG A 110
ILE A 125
LEU A  42
 None
 1.11A 4acaC-3by5A:
undetectable		 4acaC-3by5A:
14.94