SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3by9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 3by9 SENSOR PROTEIN
(Vibrio
cholerae) 		3 / 3 PHE A 122
LEU A 118
SER A 114
 SIN  A 287 (-3.7A)
None
None
 0.85A 1e7aA-3by9A:
undetectable		 1e7aA-3by9A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_E_SAME500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 3by9 SENSOR PROTEIN
(Vibrio
cholerae) 		5 / 11 SER A 213
TRP A 209
SER A 204
TRP A 252
GLN A 199
 None
 1.40A 2c2bE-3by9A:
undetectable
2c2bF-3by9A:
undetectable		 2c2bE-3by9A:
18.85
2c2bF-3by9A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_F_SAMF500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 3by9 SENSOR PROTEIN
(Vibrio
cholerae) 		5 / 10 TRP A 252
GLN A 199
SER A 213
TRP A 209
SER A 204
 None
 1.43A 2c2bE-3by9A:
0.0
2c2bF-3by9A:
0.0		 2c2bE-3by9A:
18.85
2c2bF-3by9A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_A_SAMA1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 3by9 SENSOR PROTEIN
(Vibrio
cholerae) 		4 / 4 SER A  46
GLU A 248
GLN A  32
ASP A  43
 None
 1.16A 2cl5A-3by9A:
0.0		 2cl5A-3by9A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 3by9 SENSOR PROTEIN
(Vibrio
cholerae) 		4 / 6 SER A  46
GLU A 248
GLN A  32
ASP A  43
 None
 1.16A 2cl5B-3by9A:
undetectable		 2cl5B-3by9A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 3by9 SENSOR PROTEIN
(Vibrio
cholerae) 		4 / 8 VAL A 201
VAL A 193
LEU A 210
PRO A 207
 None
 1.08A 2ddwA-3by9A:
undetectable		 2ddwA-3by9A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3by9 SENSOR PROTEIN
(Vibrio
cholerae) 		4 / 7 VAL A 266
SER A 268
ARG A 279
THR A 195
 None
 1.09A 2f78B-3by9A:
undetectable		 2f78B-3by9A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 3by9 SENSOR PROTEIN
(Vibrio
cholerae) 		3 / 3 SER A 267
ARG A 269
GLN A  39
 None
 1.02A 2xnrA-3by9A:
undetectable		 2xnrA-3by9A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3by9 SENSOR PROTEIN
(Vibrio
cholerae) 		4 / 6 SER A  46
GLU A 248
GLN A  32
ASP A  43
 None
 1.16A 2zvjA-3by9A:
undetectable		 2zvjA-3by9A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3by9 SENSOR PROTEIN
(Vibrio
cholerae) 		5 / 10 ILE A 123
ILE A 111
GLY A 170
TYR A 132
LEU A  89
 None
None
None
SIN  A 287 (-4.4A)
None
 1.37A 3elzB-3by9A:
undetectable		 3elzB-3by9A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3by9 SENSOR PROTEIN
(Vibrio
cholerae) 		5 / 10 ALA A  98
VAL A  92
ALA A 159
ILE A 172
LEU A  69
 None
 1.23A 3fl9A-3by9A:
undetectable		 3fl9A-3by9A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3by9 SENSOR PROTEIN
(Vibrio
cholerae) 		4 / 8 TRP A 185
GLU A 182
SER A 205
MET A 203
 None
 1.31A 3jx1A-3by9A:
undetectable
3jx1B-3by9A:
undetectable		 3jx1A-3by9A:
19.42
3jx1B-3by9A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3by9 SENSOR PROTEIN
(Vibrio
cholerae) 		4 / 8 TRP A 185
GLU A 182
SER A 205
MET A 203
 None
 1.35A 3nlyA-3by9A:
undetectable
3nlyB-3by9A:
undetectable		 3nlyA-3by9A:
19.42
3nlyB-3by9A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3by9 SENSOR PROTEIN
(Vibrio
cholerae) 		4 / 8 TRP A 185
GLU A 182
SER A 205
MET A 203
 None
 1.35A 3rqlA-3by9A:
undetectable
3rqlB-3by9A:
undetectable		 3rqlA-3by9A:
19.42
3rqlB-3by9A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3by9 SENSOR PROTEIN
(Vibrio
cholerae) 		4 / 5 GLN A 140
LEU A 135
SER A 136
ASP A  54
 None
 0.91A 4qtuD-3by9A:
undetectable		 4qtuD-3by9A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3by9 SENSOR PROTEIN
(Vibrio
cholerae) 		5 / 12 TYR A 102
ALA A  99
ALA A  98
TYR A 157
TYR A 132
 None
None
None
SIN  A 287 (-4.5A)
SIN  A 287 (-4.4A)
 1.45A 4u15B-3by9A:
undetectable		 4u15B-3by9A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3by9 SENSOR PROTEIN
(Vibrio
cholerae) 		4 / 5 SER A  46
GLU A 248
GLN A  32
ASP A  43
 None
 1.18A 5fhrB-3by9A:
undetectable		 5fhrB-3by9A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 3by9 SENSOR PROTEIN
(Vibrio
cholerae) 		6 / 10 TYR A 132
TYR A 102
ILE A 104
ILE A 172
ILE A 137
ILE A 168
 SIN  A 287 (-4.4A)
None
None
None
None
None
 1.28A 5murE-3by9A:
undetectable		 5murE-3by9A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 3by9 SENSOR PROTEIN
(Vibrio
cholerae) 		3 / 3 TYR A 264
SER A 190
TRP A 209
 None
 0.90A 5n8jB-3by9A:
undetectable		 5n8jB-3by9A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 3by9 SENSOR PROTEIN
(Vibrio
cholerae) 		3 / 3 TYR A 264
SER A 190
TRP A 209
 None
 0.92A 5n8jA-3by9A:
undetectable		 5n8jA-3by9A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 3by9 SENSOR PROTEIN
(Vibrio
cholerae) 		3 / 3 TYR A 264
SER A 190
TRP A 209
 None
 0.94A 5n8jD-3by9A:
undetectable		 5n8jD-3by9A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3by9 SENSOR PROTEIN
(Vibrio
cholerae) 		4 / 8 SER A 205
MET A 203
TRP A 185
GLU A 182
 None
 1.29A 5uo7A-3by9A:
undetectable
5uo7B-3by9A:
undetectable		 5uo7A-3by9A:
23.77
5uo7B-3by9A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 3by9 SENSOR PROTEIN
(Vibrio
cholerae) 		3 / 3 LEU A 274
VAL A  50
ASP A  54
 None
 0.56A 5x23A-3by9A:
undetectable		 5x23A-3by9A:
18.45