SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3byi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 3byi RHO GTPASE
ACTIVATING PROTEIN
15
(Homo
sapiens) 		5 / 11 LEU A 463
VAL A 417
ILE A 416
LEU A 438
LEU A 409
 None
 1.34A 1mrqA-3byiA:
undetectable		 1mrqA-3byiA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 3byi RHO GTPASE
ACTIVATING PROTEIN
15
(Homo
sapiens) 		3 / 3 PHE A 359
LEU A 409
MET A 462
 None
 0.85A 1mx1D-3byiA:
undetectable		 1mx1D-3byiA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 3byi RHO GTPASE
ACTIVATING PROTEIN
15
(Homo
sapiens) 		5 / 11 ASN A 423
ILE A 416
LEU A 430
VAL A 305
HIS A 349
 None
 1.47A 1tw4A-3byiA:
undetectable		 1tw4A-3byiA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 3byi RHO GTPASE
ACTIVATING PROTEIN
15
(Homo
sapiens) 		4 / 7 LEU A 409
LEU A 413
PHE A 410
LEU A 366
 None
 1.00A 2vq5B-3byiA:
undetectable		 2vq5B-3byiA:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 3byi RHO GTPASE
ACTIVATING PROTEIN
15
(Homo
sapiens) 		3 / 3 THR A 445
HIS A 451
ASN A 447
 None
 0.95A 5n4tA-3byiA:
undetectable		 5n4tA-3byiA:
22.48