SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bzj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3bzj UV ENDONUCLEASE
(Thermus
thermophilus) 		3 / 3 GLU A 175
HIS A 203
HIS A 143
 None
MN  A 281 (-3.3A)
None
 0.46A 1oe2A-3bzjA:
undetectable		 1oe2A-3bzjA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 3bzj UV ENDONUCLEASE
(Thermus
thermophilus) 		3 / 3 ARG A 227
GLY A 262
PRO A 261
 None
 0.70A 2hreD-3bzjA:
undetectable		 2hreD-3bzjA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 3bzj UV ENDONUCLEASE
(Thermus
thermophilus) 		4 / 6 ARG A  40
THR A  16
ALA A  15
ARG A  19
 None
 1.23A 2ql8A-3bzjA:
undetectable
2ql8B-3bzjA:
undetectable		 2ql8A-3bzjA:
19.38
2ql8B-3bzjA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 3bzj UV ENDONUCLEASE
(Thermus
thermophilus) 		4 / 4 ARG A 218
ASP A 265
GLY A 226
THR A 223
 None
 0.96A 3k4vB-3bzjA:
undetectable		 3k4vB-3bzjA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 3bzj UV ENDONUCLEASE
(Thermus
thermophilus) 		4 / 8 HIS A 101
VAL A 141
VAL A 139
ASP A 200
 None
None
None
MN  A 281 ( 3.8A)
 1.12A 3uy4A-3bzjA:
undetectable		 3uy4A-3bzjA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 3bzj UV ENDONUCLEASE
(Thermus
thermophilus) 		4 / 5 LEU A  42
LEU A  63
MET A 100
TRP A  76
 None
 1.27A 4do3A-3bzjA:
undetectable		 4do3A-3bzjA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3bzj UV ENDONUCLEASE
(Thermus
thermophilus) 		4 / 6 GLU A 185
ASN A 207
GLU A 269
VAL A 141
 None
None
MN  A 281 ( 4.9A)
None
 0.99A 4ejwB-3bzjA:
undetectable		 4ejwB-3bzjA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3bzj UV ENDONUCLEASE
(Thermus
thermophilus) 		4 / 8 LEU A 229
ARG A  58
VAL A 139
VAL A 141
 None
 1.00A 4em2A-3bzjA:
undetectable		 4em2A-3bzjA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 3bzj UV ENDONUCLEASE
(Thermus
thermophilus) 		5 / 12 LEU A 219
PRO A 261
ALA A 264
LEU A 213
GLY A 209
 None
 1.33A 4l9qA-3bzjA:
undetectable		 4l9qA-3bzjA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 3bzj UV ENDONUCLEASE
(Thermus
thermophilus) 		4 / 7 HIS A 231
ASN A 176
HIS A 143
VAL A 141
 None
 0.78A 4p6sA-3bzjA:
undetectable		 4p6sA-3bzjA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 3bzj UV ENDONUCLEASE
(Thermus
thermophilus) 		4 / 7 HIS A 231
ASN A 176
HIS A 143
VAL A 141
 None
 0.78A 4p6sB-3bzjA:
undetectable		 4p6sB-3bzjA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 3bzj UV ENDONUCLEASE
(Thermus
thermophilus) 		4 / 7 HIS A 231
HIS A 203
ASN A 176
HIS A 143
 None
MN  A 281 (-3.3A)
None
None
 0.89A 4p6sB-3bzjA:
undetectable		 4p6sB-3bzjA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 3bzj UV ENDONUCLEASE
(Thermus
thermophilus) 		4 / 6 LEU A 172
HIS A 101
HIS A 231
GLU A 175
 None
 1.12A 4pahA-3bzjA:
undetectable		 4pahA-3bzjA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 3bzj UV ENDONUCLEASE
(Thermus
thermophilus) 		5 / 11 HIS A 231
GLU A 175
GLU A 269
GLY A 242
HIS A 143
 None
None
MN  A 281 ( 4.9A)
None
None
 0.91A 4pqaA-3bzjA:
undetectable		 4pqaA-3bzjA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3bzj UV ENDONUCLEASE
(Thermus
thermophilus) 		4 / 8 LEU A  39
THR A  17
LEU A 129
LEU A  84
 None
 0.65A 4z90F-3bzjA:
undetectable
4z90G-3bzjA:
undetectable
4z90H-3bzjA:
undetectable
4z90I-3bzjA:
undetectable
4z90J-3bzjA:
undetectable		 4z90F-3bzjA:
21.26
4z90G-3bzjA:
21.26
4z90H-3bzjA:
21.26
4z90I-3bzjA:
21.26
4z90J-3bzjA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 3bzj UV ENDONUCLEASE
(Thermus
thermophilus) 		5 / 7 HIS A 101
HIS A 231
HIS A 203
ASN A 176
VAL A 141
 None
None
MN  A 281 (-3.3A)
None
None
 1.23A 5i3aA-3bzjA:
undetectable		 5i3aA-3bzjA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 3bzj UV ENDONUCLEASE
(Thermus
thermophilus) 		5 / 7 HIS A 231
HIS A 203
ASN A 176
HIS A 143
VAL A 141
 None
MN  A 281 (-3.3A)
None
None
None
 0.91A 5i3aA-3bzjA:
undetectable		 5i3aA-3bzjA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 3bzj UV ENDONUCLEASE
(Thermus
thermophilus) 		5 / 7 HIS A 101
HIS A 231
HIS A 203
ASN A 176
VAL A 141
 None
None
MN  A 281 (-3.3A)
None
None
 1.24A 5i3aB-3bzjA:
undetectable		 5i3aB-3bzjA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 3bzj UV ENDONUCLEASE
(Thermus
thermophilus) 		5 / 7 HIS A 231
HIS A 203
ASN A 176
HIS A 143
VAL A 141
 None
MN  A 281 (-3.3A)
None
None
None
 0.92A 5i3aB-3bzjA:
undetectable		 5i3aB-3bzjA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 3bzj UV ENDONUCLEASE
(Thermus
thermophilus) 		5 / 7 HIS A 101
HIS A 231
HIS A 203
ASN A 176
VAL A 141
 None
None
MN  A 281 (-3.3A)
None
None
 1.22A 5i3bA-3bzjA:
undetectable		 5i3bA-3bzjA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 3bzj UV ENDONUCLEASE
(Thermus
thermophilus) 		5 / 7 HIS A 231
HIS A 203
ASN A 176
HIS A 143
VAL A 141
 None
MN  A 281 (-3.3A)
None
None
None
 0.92A 5i3bA-3bzjA:
undetectable		 5i3bA-3bzjA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 3bzj UV ENDONUCLEASE
(Thermus
thermophilus) 		4 / 7 LEU A 133
THR A  17
THR A  16
LEU A 130
 None
 0.81A 5jq7B-3bzjA:
undetectable		 5jq7B-3bzjA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3bzj UV ENDONUCLEASE
(Thermus
thermophilus) 		4 / 7 HIS A 231
HIS A 143
LEU A 144
VAL A 141
 None
 0.91A 5m8rA-3bzjA:
undetectable		 5m8rA-3bzjA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3bzj UV ENDONUCLEASE
(Thermus
thermophilus) 		5 / 7 HIS A 231
HIS A 203
ASN A 176
HIS A 143
VAL A 141
 None
MN  A 281 (-3.3A)
None
None
None
 0.99A 5m8rA-3bzjA:
undetectable		 5m8rA-3bzjA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3bzj UV ENDONUCLEASE
(Thermus
thermophilus) 		4 / 8 HIS A 231
HIS A 143
LEU A 144
VAL A 141
 None
 0.91A 5m8rB-3bzjA:
undetectable		 5m8rB-3bzjA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3bzj UV ENDONUCLEASE
(Thermus
thermophilus) 		5 / 8 HIS A 231
HIS A 203
ASN A 176
HIS A 143
VAL A 141
 None
MN  A 281 (-3.3A)
None
None
None
 1.05A 5m8rB-3bzjA:
undetectable		 5m8rB-3bzjA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3bzj UV ENDONUCLEASE
(Thermus
thermophilus) 		4 / 8 HIS A 231
HIS A 143
LEU A 144
VAL A 141
 None
 0.89A 5m8rC-3bzjA:
undetectable		 5m8rC-3bzjA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3bzj UV ENDONUCLEASE
(Thermus
thermophilus) 		4 / 8 HIS A 231
HIS A 143
LEU A 144
VAL A 141
 None
 0.88A 5m8rD-3bzjA:
undetectable		 5m8rD-3bzjA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3bzj UV ENDONUCLEASE
(Thermus
thermophilus) 		5 / 8 HIS A 231
HIS A 203
ASN A 176
HIS A 143
VAL A 141
 None
MN  A 281 (-3.3A)
None
None
None
 1.01A 5m8rD-3bzjA:
undetectable		 5m8rD-3bzjA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3bzj UV ENDONUCLEASE
(Thermus
thermophilus) 		4 / 4 ASP A 200
HIS A 203
HIS A 143
HIS A 231
 MN  A 281 ( 3.8A)
MN  A 281 (-3.3A)
None
None
 0.97A 5ncdD-3bzjA:
4.0		 5ncdD-3bzjA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3bzj UV ENDONUCLEASE
(Thermus
thermophilus) 		4 / 6 ASP A 200
HIS A 203
HIS A 143
HIS A 231
 MN  A 281 ( 3.8A)
MN  A 281 (-3.3A)
None
None
 0.97A 5nelB-3bzjA:
3.8
5nelC-3bzjA:
3.8		 5nelB-3bzjA:
20.66
5nelC-3bzjA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3bzj UV ENDONUCLEASE
(Thermus
thermophilus) 		5 / 9 VAL A 159
VAL A 186
LEU A 162
LEU A 142
VAL A 195
 None
 1.24A 6czmB-3bzjA:
undetectable
6czmC-3bzjA:
undetectable		 6czmB-3bzjA:
24.87
6czmC-3bzjA:
24.87