SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bzw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 3bzw PUTATIVE LIPASE
(Bacteroides
thetaiotaomicron) 		4 / 7 ASP A 203
SER A 191
ASN A 242
GLN A 248
 None
 1.00A 2cmlA-3bzwA:
undetectable		 2cmlA-3bzwA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 3bzw PUTATIVE LIPASE
(Bacteroides
thetaiotaomicron) 		4 / 8 ASP A 203
SER A 191
ASN A 242
GLN A 248
 None
 0.99A 2cmlB-3bzwA:
undetectable		 2cmlB-3bzwA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 3bzw PUTATIVE LIPASE
(Bacteroides
thetaiotaomicron) 		4 / 8 ASP A 203
SER A 191
ASN A 242
GLN A 248
 None
 1.03A 2cmlD-3bzwA:
undetectable		 2cmlD-3bzwA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3bzw PUTATIVE LIPASE
(Bacteroides
thetaiotaomicron) 		4 / 5 ILE A 170
ARG A 165
MET A 157
THR A 158
 None
 1.47A 3abkN-3bzwA:
undetectable
3abkW-3bzwA:
undetectable		 3abkN-3bzwA:
18.49
3abkW-3bzwA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 3bzw PUTATIVE LIPASE
(Bacteroides
thetaiotaomicron) 		4 / 8 VAL A 108
ILE A 182
VAL A 113
GLY A  49
 None
 0.89A 3hjoB-3bzwA:
undetectable		 3hjoB-3bzwA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3bzw PUTATIVE LIPASE
(Bacteroides
thetaiotaomicron) 		4 / 8 PHE A 114
ILE A  65
LEU A 188
PHE A 252
 None
 0.93A 3rqwI-3bzwA:
undetectable
3rqwJ-3bzwA:
undetectable		 3rqwI-3bzwA:
20.18
3rqwJ-3bzwA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 3bzw PUTATIVE LIPASE
(Bacteroides
thetaiotaomicron) 		4 / 7 PHE A 235
ALA A 271
ILE A  78
LEU A 278
 None
 0.92A 4uymA-3bzwA:
undetectable		 4uymA-3bzwA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 3bzw PUTATIVE LIPASE
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 184
GLY A 229
GLY A 225
ILE A 111
LEU A 173
 None
 0.97A 5l0zA-3bzwA:
undetectable		 5l0zA-3bzwA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bzw PUTATIVE LIPASE
(Bacteroides
thetaiotaomicron) 		5 / 9 GLY A  84
TYR A  68
VAL A  82
ASP A  53
PRO A  58
 None
None
None
ACT  A 301 (-3.5A)
None
 1.22A 5zniA-3bzwA:
2.3		 5zniA-3bzwA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_0
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 3bzw PUTATIVE LIPASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLN A 133
THR A 154
THR A 131
VAL A 156
THR A 158
 None
 1.31A 6ak3A-3bzwA:
undetectable		 6ak3A-3bzwA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3bzw PUTATIVE LIPASE
(Bacteroides
thetaiotaomicron) 		5 / 11 GLY A  87
GLN A  96
THR A  56
ARG A 165
GLY A 116
 ACT  A 301 (-3.3A)
None
None
None
None
 1.37A 6nknA-3bzwA:
undetectable
6nknB-3bzwA:
undetectable
6nknT-3bzwA:
undetectable		 6nknA-3bzwA:
18.49
6nknB-3bzwA:
19.11
6nknT-3bzwA:
14.87