SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c02'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3c02 AQUAGLYCEROPORIN
(Plasmodium
falciparum) 		3 / 3 LEU A 245
PRO A 244
LEU A 248
 None
 0.59A 2po5B-3c02A:
undetectable		 2po5B-3c02A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3c02 AQUAGLYCEROPORIN
(Plasmodium
falciparum) 		3 / 3 LEU A 245
PRO A 244
LEU A 248
 None
 0.54A 3hcrA-3c02A:
undetectable		 3hcrA-3c02A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3c02 AQUAGLYCEROPORIN
(Plasmodium
falciparum) 		5 / 11 LEU A 144
GLY A 230
LEU A 192
ARG A 196
ASN A  70
 None
None
None
GOL  A 662 (-3.9A)
GOL  A 663 (-4.1A)
 1.12A 3ndvA-3c02A:
undetectable
3ndvB-3c02A:
undetectable		 3ndvA-3c02A:
22.45
3ndvB-3c02A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3c02 AQUAGLYCEROPORIN
(Plasmodium
falciparum) 		5 / 11 GLY A 230
LEU A 192
ARG A 196
ASN A  70
LEU A 144
 None
None
GOL  A 662 (-3.9A)
GOL  A 663 (-4.1A)
None
 1.14A 3ndvC-3c02A:
undetectable
3ndvD-3c02A:
undetectable		 3ndvC-3c02A:
22.45
3ndvD-3c02A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3c02 AQUAGLYCEROPORIN
(Plasmodium
falciparum) 		5 / 12 LEU A  69
ALA A  53
GLY A  51
GLY A  57
ALA A  30
 GOL  A 663 (-4.1A)
None
None
None
None
 1.06A 3ou6A-3c02A:
undetectable		 3ou6A-3c02A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3c02 AQUAGLYCEROPORIN
(Plasmodium
falciparum) 		5 / 12 LEU A  69
ALA A  53
GLY A  51
GLY A  57
ALA A  30
 GOL  A 663 (-4.1A)
None
None
None
None
 1.06A 3ou6B-3c02A:
undetectable		 3ou6B-3c02A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3c02 AQUAGLYCEROPORIN
(Plasmodium
falciparum) 		5 / 12 LEU A  69
ALA A  53
GLY A  51
GLY A  57
ALA A  30
 GOL  A 663 (-4.1A)
None
None
None
None
 1.03A 3ou7B-3c02A:
undetectable		 3ou7B-3c02A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 3c02 AQUAGLYCEROPORIN
(Plasmodium
falciparum) 		4 / 5 PHE A  83
ILE A  88
GLY A  76
HIS A  68
 None
None
None
GOL  A 665 ( 4.8A)
 1.25A 3r0lD-3c02A:
undetectable		 3r0lD-3c02A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 3c02 AQUAGLYCEROPORIN
(Plasmodium
falciparum) 		4 / 8 SER A 171
ALA A  62
LEU A  59
SER A 170
 None
 0.87A 4iklA-3c02A:
undetectable
4iklB-3c02A:
undetectable		 4iklA-3c02A:
20.87
4iklB-3c02A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 3c02 AQUAGLYCEROPORIN
(Plasmodium
falciparum) 		6 / 12 GLY A 174
VAL A 173
ILE A 176
LEU A 192
LEU A 149
ILE A 143
 None
 1.50A 4pd4C-3c02A:
undetectable		 4pd4C-3c02A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 3c02 AQUAGLYCEROPORIN
(Plasmodium
falciparum) 		4 / 7 ALA A  32
THR A  31
ALA A  30
THR A  37
 None
 0.99A 4qw0K-3c02A:
undetectable		 4qw0K-3c02A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 3c02 AQUAGLYCEROPORIN
(Plasmodium
falciparum) 		4 / 7 ALA A  32
THR A  31
ALA A  30
THR A  37
 None
 0.99A 4qw0Y-3c02A:
undetectable		 4qw0Y-3c02A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_ACTA202_0
(RETINOL-BINDING
PROTEIN 2)		 3c02 AQUAGLYCEROPORIN
(Plasmodium
falciparum) 		4 / 6 TYR A 208
GLU A  28
THR A 103
LEU A 203
 None
 1.45A 4qztA-3c02A:
undetectable		 4qztA-3c02A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 3c02 AQUAGLYCEROPORIN
(Plasmodium
falciparum) 		5 / 12 THR A 103
VAL A 106
GLU A 125
ILE A 119
HIS A  35
 None
 1.20A 4s0vA-3c02A:
2.3		 4s0vA-3c02A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 3c02 AQUAGLYCEROPORIN
(Plasmodium
falciparum) 		4 / 6 LEU A 109
TRP A 124
PHE A 113
THR A  36
 None
 1.11A 4udaA-3c02A:
undetectable		 4udaA-3c02A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 3c02 AQUAGLYCEROPORIN
(Plasmodium
falciparum) 		5 / 12 GLY A  51
ILE A 177
TRP A  43
TYR A  44
LEU A 192
 None
GOL  A 662 ( 4.5A)
None
None
None
 1.42A 5nz0A-3c02A:
3.6		 5nz0A-3c02A:
20.96