SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c0b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 3c0b CONSERVED ARCHAEAL
PROTEIN Q6M145
(Methanococcus
maripaludis) 		4 / 6 SER A 238
ILE A 243
ALA A 248
ALA A 196
 None
 0.96A 1w0gA-3c0bA:
undetectable		 1w0gA-3c0bA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 3c0b CONSERVED ARCHAEAL
PROTEIN Q6M145
(Methanococcus
maripaludis) 		5 / 12 VAL A 267
THR A 138
MET A 134
ASP A 140
HIS A 176
 None
 1.37A 2qo4A-3c0bA:
undetectable		 2qo4A-3c0bA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3c0b CONSERVED ARCHAEAL
PROTEIN Q6M145
(Methanococcus
maripaludis) 		4 / 8 GLU A  80
ASN A  77
ILE A  75
LYS A  37
 None
 0.98A 3kp6A-3c0bA:
0.0
3kp6B-3c0bA:
undetectable		 3kp6A-3c0bA:
21.88
3kp6B-3c0bA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3c0b CONSERVED ARCHAEAL
PROTEIN Q6M145
(Methanococcus
maripaludis) 		3 / 3 TYR A 194
ASP A 200
ASP A 224
 None
 0.82A 3ou6B-3c0bA:
undetectable		 3ou6B-3c0bA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 3c0b CONSERVED ARCHAEAL
PROTEIN Q6M145
(Methanococcus
maripaludis) 		3 / 3 THR A 137
SER A 136
ARG A 171
 None
 0.73A 3phnA-3c0bA:
undetectable		 3phnA-3c0bA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 3c0b CONSERVED ARCHAEAL
PROTEIN Q6M145
(Methanococcus
maripaludis) 		3 / 3 LYS A 273
VAL A 270
HIS A 162
 None
 1.08A 3tj7A-3c0bA:
undetectable		 3tj7A-3c0bA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 3c0b CONSERVED ARCHAEAL
PROTEIN Q6M145
(Methanococcus
maripaludis) 		5 / 9 LEU A  99
ALA A  79
VAL A  50
LEU A   3
ILE A  87
 None
 1.27A 3wsjA-3c0bA:
undetectable		 3wsjA-3c0bA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3c0b CONSERVED ARCHAEAL
PROTEIN Q6M145
(Methanococcus
maripaludis) 		3 / 3 ASP A 140
ASN A 266
SER A 136
 None
 0.80A 4obwA-3c0bA:
undetectable		 4obwA-3c0bA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3c0b CONSERVED ARCHAEAL
PROTEIN Q6M145
(Methanococcus
maripaludis) 		4 / 5 ILE A 281
LYS A 260
ILE A 263
VAL A 267
 None
 0.91A 5jmnA-3c0bA:
undetectable		 5jmnA-3c0bA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3c0b CONSERVED ARCHAEAL
PROTEIN Q6M145
(Methanococcus
maripaludis) 		4 / 6 ILE A  97
ILE A   2
LEU A 326
HIS A 329
 None
 0.95A 5vkqB-3c0bA:
undetectable
5vkqC-3c0bA:
undetectable		 5vkqB-3c0bA:
11.93
5vkqC-3c0bA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3c0b CONSERVED ARCHAEAL
PROTEIN Q6M145
(Methanococcus
maripaludis) 		4 / 6 ILE A  97
ILE A   2
LEU A 326
HIS A 329
 None
 0.92A 5vkqC-3c0bA:
undetectable
5vkqD-3c0bA:
undetectable		 5vkqC-3c0bA:
11.93
5vkqD-3c0bA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3c0b CONSERVED ARCHAEAL
PROTEIN Q6M145
(Methanococcus
maripaludis) 		4 / 6 GLY A 306
TYR A 305
LEU A 311
VAL A  25
 None
 0.96A 5x80A-3c0bA:
2.2
5x80B-3c0bA:
2.1		 5x80A-3c0bA:
20.27
5x80B-3c0bA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 3c0b CONSERVED ARCHAEAL
PROTEIN Q6M145
(Methanococcus
maripaludis) 		5 / 12 LEU A 284
GLY A 135
VAL A 279
VAL A 132
ASP A 140
 None
 1.12A 6bxlB-3c0bA:
undetectable		 6bxlB-3c0bA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 3c0b CONSERVED ARCHAEAL
PROTEIN Q6M145
(Methanococcus
maripaludis) 		4 / 5 LEU A 170
THR A 169
THR A 138
GLY A 135
 None
 0.84A 6gtqA-3c0bA:
undetectable		 6gtqA-3c0bA:
18.02