SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c0i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
3 / 3 VAL A 207
VAL A 253
TRP A 203
None
0.88A 1av2A-3c0iA:
undetectable
1av2B-3c0iA:
undetectable
1av2A-3c0iA:
4.76
1av2B-3c0iA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
3 / 3 TRP A 275
TYR A 284
LEU A 288
None
1.04A 1kxhA-3c0iA:
undetectable
1kxhA-3c0iA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
5 / 11 GLY A 204
PHE A 185
PHE A 227
VAL A 190
VAL A 191
None
1.15A 1ukbA-3c0iA:
undetectable
1ukbA-3c0iA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
4 / 6 ILE A  18
VAL A  26
ILE A  74
ILE A 137
3AM  A 338 (-4.5A)
3AM  A 338 ( 4.1A)
None
None
0.81A 1uwhB-3c0iA:
24.6
1uwhB-3c0iA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
3 / 3 VAL A 207
VAL A 253
TRP A 203
None
0.79A 1w5uA-3c0iA:
undetectable
1w5uB-3c0iA:
undetectable
1w5uA-3c0iA:
4.76
1w5uB-3c0iA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
6 / 12 ILE A  18
VAL A  26
LYS A  41
VAL A  75
PHE A  91
LEU A 148
3AM  A 338 (-4.5A)
3AM  A 338 ( 4.1A)
3AM  A 338 (-2.9A)
None
3AM  A 338 (-3.6A)
3AM  A 338 (-4.7A)
0.56A 2eufB-3c0iA:
21.7
2eufB-3c0iA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
3 / 3 VAL A 253
TRP A 203
VAL A 207
None
0.74A 2izqC-3c0iA:
undetectable
2izqD-3c0iA:
undetectable
2izqC-3c0iA:
4.76
2izqD-3c0iA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
3 / 3 GLN A 124
LYS A 159
VAL A 147
None
0.63A 2jfaB-3c0iA:
undetectable
2jfaB-3c0iA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
6 / 12 ILE A  18
VAL A  26
ALA A  39
PHE A  91
MET A  94
LEU A 148
3AM  A 338 (-4.5A)
3AM  A 338 ( 4.1A)
3AM  A 338 (-3.3A)
3AM  A 338 (-3.6A)
None
3AM  A 338 (-4.7A)
0.66A 2y7jA-3c0iA:
33.0
2y7jA-3c0iA:
28.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
6 / 10 ILE A  18
VAL A  26
ALA A  39
PHE A  91
MET A  94
LEU A 148
3AM  A 338 (-4.5A)
3AM  A 338 ( 4.1A)
3AM  A 338 (-3.3A)
3AM  A 338 (-3.6A)
None
3AM  A 338 (-4.7A)
0.77A 2y7jB-3c0iA:
32.8
2y7jB-3c0iA:
28.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
6 / 10 ILE A  18
VAL A  26
ALA A  39
PHE A  91
MET A  94
LEU A 148
3AM  A 338 (-4.5A)
3AM  A 338 ( 4.1A)
3AM  A 338 (-3.3A)
3AM  A 338 (-3.6A)
None
3AM  A 338 (-4.7A)
0.73A 2y7jC-3c0iA:
33.0
2y7jC-3c0iA:
28.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
6 / 10 ILE A  18
VAL A  26
ALA A  39
PHE A  91
MET A  94
LEU A 148
3AM  A 338 (-4.5A)
3AM  A 338 ( 4.1A)
3AM  A 338 (-3.3A)
3AM  A 338 (-3.6A)
None
3AM  A 338 (-4.7A)
0.83A 2y7jD-3c0iA:
32.5
2y7jD-3c0iA:
28.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
3 / 3 ASP A 141
THR A  56
GLU A  62
None
0.73A 2zifB-3c0iA:
undetectable
2zifB-3c0iA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
4 / 6 GLN A 124
LEU A 126
GLU A 127
LEU A 271
None
0.87A 3h5gA-3c0iA:
undetectable
3h5gC-3c0iA:
undetectable
3h5gA-3c0iA:
7.17
3h5gC-3c0iA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
5 / 12 LEU A 209
LEU A 276
LYS A 277
ILE A 125
TYR A 113
None
1.16A 3hj3B-3c0iA:
undetectable
3hj3B-3c0iA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
6 / 11 ILE A  18
ALA A  39
LYS A  41
PHE A  91
PHE A  93
MET A  94
3AM  A 338 (-4.5A)
3AM  A 338 (-3.3A)
3AM  A 338 (-2.9A)
3AM  A 338 (-3.6A)
3AM  A 338 ( 4.6A)
None
0.81A 3miyA-3c0iA:
24.3
3miyA-3c0iA:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
5 / 9 ILE A  18
ALA A  39
PHE A  91
PHE A  93
MET A  94
3AM  A 338 (-4.5A)
3AM  A 338 (-3.3A)
3AM  A 338 (-3.6A)
3AM  A 338 ( 4.6A)
None
0.58A 3miyB-3c0iA:
24.0
3miyB-3c0iA:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
6 / 9 ILE A  18
ALA A  39
PHE A  93
MET A  94
GLY A  96
LEU A 148
3AM  A 338 (-4.5A)
3AM  A 338 (-3.3A)
3AM  A 338 ( 4.6A)
None
None
3AM  A 338 (-4.7A)
1.26A 3miyB-3c0iA:
24.0
3miyB-3c0iA:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
6 / 9 ILE A  18
ALA A  39
VAL A  75
PHE A  91
PHE A  93
LEU A 148
3AM  A 338 (-4.5A)
3AM  A 338 (-3.3A)
None
3AM  A 338 (-3.6A)
3AM  A 338 ( 4.6A)
3AM  A 338 (-4.7A)
0.60A 3ti1A-3c0iA:
23.9
3ti1A-3c0iA:
28.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
5 / 10 ILE A 167
GLY A 197
TYR A 196
GLY A 173
SER A 172
None
1.00A 4bwlC-3c0iA:
undetectable
4bwlC-3c0iA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
4 / 8 VAL A 267
HIS A 139
ASP A 201
HIS A 133
None
0.91A 4exsB-3c0iA:
undetectable
4exsB-3c0iA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
6 / 10 ILE A  18
ALA A  39
VAL A  75
PHE A  93
GLY A  96
LEU A 148
3AM  A 338 (-4.5A)
3AM  A 338 (-3.3A)
None
3AM  A 338 ( 4.6A)
None
3AM  A 338 (-4.7A)
1.14A 4ks8A-3c0iA:
29.9
4ks8A-3c0iA:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
4 / 7 ALA A  39
MET A  94
ASP A  98
LEU A 148
3AM  A 338 (-3.3A)
None
None
3AM  A 338 (-4.7A)
0.58A 4l9iA-3c0iA:
11.9
4l9iA-3c0iA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
4 / 7 VAL A  26
ALA A  39
MET A  94
LEU A 148
3AM  A 338 ( 4.1A)
3AM  A 338 (-3.3A)
None
3AM  A 338 (-4.7A)
0.76A 4l9iA-3c0iA:
11.9
4l9iA-3c0iA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
7 / 12 VAL A  26
ALA A  39
LYS A  41
PHE A  93
MET A  94
GLY A  96
LEU A 148
3AM  A 338 ( 4.1A)
3AM  A 338 (-3.3A)
3AM  A 338 (-2.9A)
3AM  A 338 ( 4.6A)
None
None
3AM  A 338 (-4.7A)
0.89A 4wa9B-3c0iA:
25.5
4wa9B-3c0iA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
4 / 8 VAL A 267
HIS A 139
ASP A 201
HIS A 133
None
0.81A 5a5zA-3c0iA:
undetectable
5a5zA-3c0iA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
4 / 7 GLY A  19
GLY A  21
VAL A  26
LYS A  41
None
None
3AM  A 338 ( 4.1A)
3AM  A 338 (-2.9A)
0.22A 5izjA-3c0iA:
21.8
5izjA-3c0iA:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
4 / 7 GLY A  19
GLY A  21
VAL A  26
LYS A  41
None
None
3AM  A 338 ( 4.1A)
3AM  A 338 (-2.9A)
0.25A 5j5xA-3c0iA:
20.3
5j5xA-3c0iA:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
7 / 12 ILE A  18
GLY A  19
VAL A  26
ALA A  39
VAL A  75
PHE A  91
LEU A 148
3AM  A 338 (-4.5A)
None
3AM  A 338 ( 4.1A)
3AM  A 338 (-3.3A)
None
3AM  A 338 (-3.6A)
3AM  A 338 (-4.7A)
0.68A 5l2iA-3c0iA:
7.7
5l2iA-3c0iA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
7 / 12 ILE A  18
GLY A  19
VAL A  26
ALA A  39
VAL A  75
PHE A  91
LEU A 148
3AM  A 338 (-4.5A)
None
3AM  A 338 ( 4.1A)
3AM  A 338 (-3.3A)
None
3AM  A 338 (-3.6A)
3AM  A 338 (-4.7A)
1.12A 5l2tA-3c0iA:
7.8
5l2tA-3c0iA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
5 / 9 ILE A  18
GLY A  19
VAL A  26
ALA A  39
MET A  94
3AM  A 338 (-4.5A)
None
3AM  A 338 ( 4.1A)
3AM  A 338 (-3.3A)
None
0.59A 5lw1B-3c0iA:
23.2
5lw1B-3c0iA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
6 / 12 GLU A  16
ALA A  39
VAL A  75
PHE A  93
GLY A  96
LEU A 148
None
3AM  A 338 (-3.3A)
None
3AM  A 338 ( 4.6A)
None
3AM  A 338 (-4.7A)
0.84A 5te0A-3c0iA:
27.7
5te0A-3c0iA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
5 / 12 VAL A 190
VAL A 200
ASP A 201
GLY A 204
LEU A 160
None
1.17A 5x24A-3c0iA:
undetectable
5x24A-3c0iA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
4 / 5 VAL A 165
PHE A  93
MET A  94
GLY A  96
None
3AM  A 338 ( 4.6A)
None
None
0.61A 6hd4A-3c0iA:
23.0
6hd4A-3c0iA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo
sapiens)
4 / 6 VAL A 165
PHE A  93
MET A  94
GLY A  96
None
3AM  A 338 ( 4.6A)
None
None
0.64A 6hd4B-3c0iA:
23.2
6hd4B-3c0iA:
15.41