SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c17'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3c17 L-ASPARAGINASE
PRECURSOR
(Escherichia
coli) 		5 / 10 ALA A   7
SER A  48
LEU A 191
ALA A 192
ILE A 280
 None
 1.14A 1g5yC-3c17A:
undetectable		 1g5yC-3c17A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 3c17 L-ASPARAGINASE
PRECURSOR
(Escherichia
coli) 		5 / 12 GLY A 178
GLY A 199
THR A 230
VAL A 180
ALA A  72
 None
 1.06A 1nv8A-3c17A:
undetectable		 1nv8A-3c17A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 3c17 L-ASPARAGINASE
PRECURSOR
(Escherichia
coli) 		5 / 12 GLY A 178
GLY A 199
THR A 230
VAL A 180
ALA A  72
 None
 1.02A 1nv8B-3c17A:
undetectable		 1nv8B-3c17A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 3c17 L-ASPARAGINASE
PRECURSOR
(Escherichia
coli) 		3 / 3 TYR A 311
ARG A  27
GLN A  23
 None
None
CL  A 332 (-4.2A)
 0.95A 1tw4A-3c17A:
undetectable		 1tw4A-3c17A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3c17 L-ASPARAGINASE
PRECURSOR
(Escherichia
coli) 		3 / 3 ASP A 304
TYR A 301
LYS A   2
 None
 1.11A 2othA-3c17A:
undetectable		 2othA-3c17A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3c17 L-ASPARAGINASE
PRECURSOR
(Escherichia
coli) 		4 / 5 LEU A 185
ALA A 226
SER A 224
LYS A   3
 None
 1.12A 2othA-3c17A:
undetectable		 2othA-3c17A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 3c17 L-ASPARAGINASE
PRECURSOR
(Escherichia
coli) 		5 / 11 ALA A 216
ALA A 241
GLY A 231
GLY A 209
ILE A 237
 None
None
NA  A 324 ( 4.1A)
CL  A 330 ( 3.9A)
None
 1.12A 2x1lA-3c17A:
undetectable		 2x1lA-3c17A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 3c17 L-ASPARAGINASE
PRECURSOR
(Escherichia
coli) 		5 / 11 ALA A 216
ALA A 241
GLY A 231
GLY A 209
ILE A 237
 None
None
NA  A 324 ( 4.1A)
CL  A 330 ( 3.9A)
None
 1.10A 2x1lC-3c17A:
undetectable		 2x1lC-3c17A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 3c17 L-ASPARAGINASE
PRECURSOR
(Escherichia
coli) 		3 / 3 GLY A 231
ASP A 210
SER A 211
 NA  A 324 ( 4.1A)
NA  A 324 ( 4.7A)
NA  A 324 ( 4.8A)
 0.66A 3brfA-3c17A:
undetectable		 3brfA-3c17A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 3c17 L-ASPARAGINASE
PRECURSOR
(Escherichia
coli) 		4 / 4 GLY A  39
VAL A  52
GLY A 181
THR A 195
 None
 0.83A 3ib2A-3c17A:
undetectable		 3ib2A-3c17A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3c17 L-ASPARAGINASE
PRECURSOR
(Escherichia
coli) 		5 / 11 LEU A  60
ILE A   8
ALA A  34
ALA A 298
THR A 308
 None
 1.10A 3mdtB-3c17A:
undetectable		 3mdtB-3c17A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 3c17 L-ASPARAGINASE
PRECURSOR
(Escherichia
coli) 		5 / 11 THR A 230
THR A 195
ALA A  84
GLY A  10
SER A 228
 None
 1.16A 3mg0N-3c17A:
2.9		 3mg0N-3c17A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3c17 L-ASPARAGINASE
PRECURSOR
(Escherichia
coli) 		5 / 12 VAL A  73
ALA A  72
GLY A  71
ALA A  84
ASN A  67
 None
None
NA  A   1 ( 4.4A)
None
None
 1.14A 3qxyA-3c17A:
undetectable		 3qxyA-3c17A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 3c17 L-ASPARAGINASE
PRECURSOR
(Escherichia
coli) 		5 / 11 VAL A  73
ALA A  72
GLY A  71
ALA A  84
ASN A  67
 None
None
NA  A   1 ( 4.4A)
None
None
 1.12A 3qxyB-3c17A:
undetectable
3qxyQ-3c17A:
undetectable		 3qxyB-3c17A:
21.04
3qxyQ-3c17A:
4.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3c17 L-ASPARAGINASE
PRECURSOR
(Escherichia
coli) 		5 / 11 VAL A  73
ALA A  72
GLY A  71
ALA A  84
ASN A  67
 None
None
NA  A   1 ( 4.4A)
None
None
 1.14A 3rc0A-3c17A:
undetectable		 3rc0A-3c17A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3c17 L-ASPARAGINASE
PRECURSOR
(Escherichia
coli) 		5 / 12 VAL A  73
ALA A  72
GLY A  71
ALA A  84
ASN A  67
 None
None
NA  A   1 ( 4.4A)
None
None
 1.13A 3rc0B-3c17A:
undetectable		 3rc0B-3c17A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_B_MIYB391_1
(TETX2 PROTEIN)		 3c17 L-ASPARAGINASE
PRECURSOR
(Escherichia
coli) 		5 / 11 PHE A  66
ASN A  67
GLY A  10
PRO A 170
GLY A 168
 None
 1.50A 4a99B-3c17A:
undetectable		 4a99B-3c17A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 3c17 L-ASPARAGINASE
PRECURSOR
(Escherichia
coli) 		4 / 8 ASN A 221
ALA A 223
SER A 224
TYR A 251
 NA  A 325 ( 4.1A)
NA  A 325 ( 4.6A)
None
None
 1.04A 4ijiF-3c17A:
undetectable		 4ijiF-3c17A:
22.87