SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c1o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 3c1o EUGENOL SYNTHASE
(Clarkia
breweri) 		5 / 12 PHE A 304
PRO A 310
LEU A 300
LEU A 224
LEU A 161
 None
 1.34A 1e7wA-3c1oA:
13.8		 1e7wA-3c1oA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 3c1o EUGENOL SYNTHASE
(Clarkia
breweri) 		4 / 6 HIS A  92
ILE A  93
ALA A 100
VAL A  78
 None
 1.02A 1hk1A-3c1oA:
undetectable		 1hk1A-3c1oA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1870_0
(FPRA)		 3c1o EUGENOL SYNTHASE
(Clarkia
breweri) 		4 / 4 HIS A  26
PRO A  27
LYS A   3
ILE A   4
 None
 1.40A 1lqtA-3c1oA:
6.6		 1lqtA-3c1oA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 3c1o EUGENOL SYNTHASE
(Clarkia
breweri) 		4 / 8 TYR A 147
GLU A 139
ARG A 117
GLU A 115
 None
 1.23A 1s3zA-3c1oA:
undetectable
1s3zB-3c1oA:
undetectable		 1s3zA-3c1oA:
19.12
1s3zB-3c1oA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3c1o EUGENOL SYNTHASE
(Clarkia
breweri) 		5 / 12 ALA A 137
ILE A 138
ALA A  99
LEU A  72
PHE A 106
 None
 1.12A 1udtA-3c1oA:
undetectable		 1udtA-3c1oA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3c1o EUGENOL SYNTHASE
(Clarkia
breweri) 		5 / 12 ALA A 137
ILE A 138
ALA A  99
LEU A  72
PHE A 106
 None
 1.09A 1uduB-3c1oA:
undetectable		 1uduB-3c1oA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 3c1o EUGENOL SYNTHASE
(Clarkia
breweri) 		4 / 7 PHE A 111
TYR A 212
ASN A 151
VAL A 210
 None
 0.98A 1wu8A-3c1oA:
undetectable
1wu8C-3c1oA:
undetectable		 1wu8A-3c1oA:
21.88
1wu8C-3c1oA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 3c1o EUGENOL SYNTHASE
(Clarkia
breweri) 		4 / 8 ASP A 173
PRO A 242
TYR A 177
LEU A 246
 None
 0.89A 1z2bB-3c1oA:
6.6		 1z2bB-3c1oA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB400_0
(HISTAMINE
N-METHYLTRANSFERASE)		 3c1o EUGENOL SYNTHASE
(Clarkia
breweri) 		5 / 12 GLU A 129
SER A  80
GLN A  90
TYR A 147
GLU A 139
 None
 1.41A 2aouB-3c1oA:
2.3		 2aouB-3c1oA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 3c1o EUGENOL SYNTHASE
(Clarkia
breweri) 		3 / 3 SER A 266
GLU A 125
ASP A 116
 None
 0.72A 2avdB-3c1oA:
6.6		 2avdB-3c1oA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3c1o EUGENOL SYNTHASE
(Clarkia
breweri) 		4 / 6 ALA A  96
TYR A   7
ILE A 103
ILE A  93
 None
 1.18A 2dcfA-3c1oA:
undetectable		 2dcfA-3c1oA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3c1o EUGENOL SYNTHASE
(Clarkia
breweri) 		5 / 12 ALA A 137
ILE A 138
ALA A  99
LEU A  72
PHE A 106
 None
 1.12A 2h42B-3c1oA:
undetectable		 2h42B-3c1oA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)		 3c1o EUGENOL SYNTHASE
(Clarkia
breweri) 		4 / 8 PRO A 123
PRO A 260
VAL A 261
SER A 262
 None
 0.77A 2v32C-3c1oA:
undetectable
2v32D-3c1oA:
undetectable		 2v32C-3c1oA:
21.36
2v32D-3c1oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)		 3c1o EUGENOL SYNTHASE
(Clarkia
breweri) 		4 / 8 PRO A 123
PRO A 260
VAL A 261
SER A 262
 None
 0.79A 2v41C-3c1oA:
undetectable
2v41D-3c1oA:
2.4		 2v41C-3c1oA:
21.36
2v41D-3c1oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 3c1o EUGENOL SYNTHASE
(Clarkia
breweri) 		4 / 8 PRO A 123
PRO A 260
VAL A 261
SER A 262
 None
 0.79A 2v41C-3c1oA:
undetectable
2v41D-3c1oA:
2.4		 2v41C-3c1oA:
21.36
2v41D-3c1oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)		 3c1o EUGENOL SYNTHASE
(Clarkia
breweri) 		4 / 8 PRO A 123
PRO A 260
VAL A 261
SER A 262
 None
 0.85A 2v41G-3c1oA:
undetectable
2v41H-3c1oA:
undetectable		 2v41G-3c1oA:
21.36
2v41H-3c1oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 3c1o EUGENOL SYNTHASE
(Clarkia
breweri) 		4 / 5 ARG A 136
ASP A 116
ILE A 209
GLU A 139
 None
 1.20A 2xrzA-3c1oA:
4.4
2xrzB-3c1oA:
4.4		 2xrzA-3c1oA:
20.97
2xrzB-3c1oA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DGQ_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 3c1o EUGENOL SYNTHASE
(Clarkia
breweri) 		4 / 5 ARG A 117
ILE A 209
TYR A 147
THR A 146
 None
 1.26A 3dgqA-3c1oA:
undetectable		 3dgqA-3c1oA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3c1o EUGENOL SYNTHASE
(Clarkia
breweri) 		4 / 6 ILE A 174
PHE A 157
PHE A 268
TYR A 177
 None
NAP  A 401 (-4.4A)
None
None
 1.29A 3elzB-3c1oA:
undetectable		 3elzB-3c1oA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3c1o EUGENOL SYNTHASE
(Clarkia
breweri) 		4 / 8 ILE A  13
TYR A 212
ASN A 217
GLY A 112
 NAP  A 401 (-4.3A)
None
None
NAP  A 401 ( 3.7A)
 0.81A 3em0B-3c1oA:
undetectable		 3em0B-3c1oA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3c1o EUGENOL SYNTHASE
(Clarkia
breweri) 		5 / 11 ILE A  94
ALA A 141
LEU A 143
ALA A 142
ILE A  87
 None
 1.02A 3fc6A-3c1oA:
undetectable		 3fc6A-3c1oA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAM_B_LLLB500_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3c1o EUGENOL SYNTHASE
(Clarkia
breweri) 		5 / 11 SER A 275
ASP A 282
SER A 266
ASP A 272
ARG A 135
 None
 1.47A 3hamB-3c1oA:
0.0		 3hamB-3c1oA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3c1o EUGENOL SYNTHASE
(Clarkia
breweri) 		3 / 3 GLY A 178
GLY A 180
THR A 182
 None
 0.42A 3si7B-3c1oA:
undetectable		 3si7B-3c1oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 3c1o EUGENOL SYNTHASE
(Clarkia
breweri) 		5 / 10 ILE A  30
SER A  52
ILE A  57
ALA A  32
GLU A  59
 None
 1.31A 3u6tA-3c1oA:
undetectable		 3u6tA-3c1oA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3c1o EUGENOL SYNTHASE
(Clarkia
breweri) 		5 / 12 GLY A   8
GLY A  14
ILE A  79
LEU A  82
PRO A  83
 NAP  A 401 (-3.6A)
None
None
None
NAP  A 401 (-3.8A)
 1.00A 4gc9A-3c1oA:
4.3		 4gc9A-3c1oA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 3c1o EUGENOL SYNTHASE
(Clarkia
breweri) 		3 / 3 LYS A 231
LEU A 227
ALA A 230
 None
 0.66A 4ikiA-3c1oA:
undetectable		 4ikiA-3c1oA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3c1o EUGENOL SYNTHASE
(Clarkia
breweri) 		5 / 12 LEU A 143
ILE A  94
ILE A  93
ALA A 100
VAL A  78
 None
 1.03A 4nkvA-3c1oA:
undetectable		 4nkvA-3c1oA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3c1o EUGENOL SYNTHASE
(Clarkia
breweri) 		5 / 12 LEU A 143
ILE A  94
ILE A  93
ALA A 100
VAL A  78
 None
 1.08A 4nkvC-3c1oA:
undetectable		 4nkvC-3c1oA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3c1o EUGENOL SYNTHASE
(Clarkia
breweri) 		5 / 12 LEU A 143
ILE A  94
ILE A  93
ALA A 100
VAL A  78
 None
 1.08A 4nkvD-3c1oA:
undetectable		 4nkvD-3c1oA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3c1o EUGENOL SYNTHASE
(Clarkia
breweri) 		5 / 12 LEU A 143
ILE A  94
ILE A  93
ALA A 100
VAL A  78
 None
 1.04A 4nkxA-3c1oA:
undetectable		 4nkxA-3c1oA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3c1o EUGENOL SYNTHASE
(Clarkia
breweri) 		3 / 3 PRO A  83
LEU A  82
HIS A  92
 NAP  A 401 (-3.8A)
None
None
 0.69A 4pevA-3c1oA:
6.4		 4pevA-3c1oA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 3c1o EUGENOL SYNTHASE
(Clarkia
breweri) 		3 / 3 ARG A 136
TYR A 145
GLU A 139
 None
 0.65A 4zzbE-3c1oA:
undetectable		 4zzbE-3c1oA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 3c1o EUGENOL SYNTHASE
(Clarkia
breweri) 		4 / 6 ASP A 173
PRO A 242
TYR A 177
LEU A 246
 None
 1.13A 5bmvB-3c1oA:
6.2		 5bmvB-3c1oA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 3c1o EUGENOL SYNTHASE
(Clarkia
breweri) 		4 / 6 GLU A 189
PRO A 310
GLY A 154
PHE A 304
 None
 1.41A 5jcnB-3c1oA:
5.9		 5jcnB-3c1oA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 3c1o EUGENOL SYNTHASE
(Clarkia
breweri) 		5 / 8 GLY A 112
PHE A 111
VAL A 210
GLY A 154
ALA A 193
 NAP  A 401 ( 3.7A)
None
None
None
None
 1.24A 6hu9H-3c1oA:
undetectable
6hu9e-3c1oA:
undetectable		 6hu9H-3c1oA:
13.38
6hu9e-3c1oA:
17.95