SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c28'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 3c28 RECOMBINASE CRE
(Escherichia
virus
P1) 		4 / 8 GLU A 138
ALA A 291
LEU A 164
THR A 268
 None
 0.90A 1ie4B-3c28A:
undetectable
1ie4D-3c28A:
undetectable		 1ie4B-3c28A:
15.96
1ie4D-3c28A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 3c28 RECOMBINASE CRE
(Escherichia
virus
P1) 		4 / 5 VAL A 242
VAL A 230
GLY A 229
TRP A 224
 None
 1.15A 2p2fA-3c28A:
undetectable		 2p2fA-3c28A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3c28 RECOMBINASE CRE
(Escherichia
virus
P1) 		4 / 7 GLY A 333
ALA A 334
MET A 335
LEU A 338
 None
 0.60A 2wekB-3c28A:
undetectable		 2wekB-3c28A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3c28 RECOMBINASE CRE
(Escherichia
virus
P1) 		4 / 6 SER A  47
ARG A 259
GLU A 266
GLU A 262
 None
 1.17A 3k9fA-3c28A:
undetectable
3k9fB-3c28A:
undetectable
3k9fD-3c28A:
undetectable		 3k9fA-3c28A:
20.78
3k9fB-3c28A:
20.78
3k9fD-3c28A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3c28 RECOMBINASE CRE
(Escherichia
virus
P1) 		3 / 4 SER A  51
GLY A  82
GLU A 123
 None
 0.69A 3raeA-3c28A:
undetectable
3raeC-3c28A:
undetectable		 3raeA-3c28A:
20.78
3raeC-3c28A:
21.64