SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c2b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3c2b TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Agrobacterium
fabrum) 		5 / 12 LEU A 212
GLY A 213
HIS A 209
LEU A 200
VAL A 196
 None
 1.14A 1dfoA-3c2bA:
undetectable		 1dfoA-3c2bA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3c2b TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Agrobacterium
fabrum) 		5 / 12 LEU A 212
GLY A 213
HIS A 209
LEU A 200
VAL A 196
 None
 1.14A 1dfoB-3c2bA:
undetectable		 1dfoB-3c2bA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3c2b TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Agrobacterium
fabrum) 		5 / 12 LEU A 212
GLY A 213
HIS A 209
LEU A 200
VAL A 196
 None
 1.15A 1dfoC-3c2bA:
undetectable		 1dfoC-3c2bA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3c2b TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Agrobacterium
fabrum) 		5 / 12 LEU A 212
GLY A 213
HIS A 209
LEU A 200
VAL A 196
 None
 1.14A 1dfoD-3c2bA:
undetectable		 1dfoD-3c2bA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 3c2b TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Agrobacterium
fabrum) 		5 / 12 PHE A 156
GLY A 148
LEU A  87
ALA A 162
PHE A 199
 None
 1.17A 1gseA-3c2bA:
undetectable		 1gseA-3c2bA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 3c2b TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Agrobacterium
fabrum) 		4 / 7 SER A 165
LEU A 202
PHE A 199
GLY A 204
 None
 0.93A 2bdmA-3c2bA:
undetectable		 2bdmA-3c2bA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLO_A_TESA1920_1
(ANDROGEN RECEPTOR)		 3c2b TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Agrobacterium
fabrum) 		5 / 12 LEU A 110
ASN A 111
LEU A 113
GLN A 117
ARG A  57
 None
 1.23A 2yloA-3c2bA:
undetectable		 2yloA-3c2bA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 3c2b TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Agrobacterium
fabrum) 		4 / 6 ARG A 134
TYR A 163
PHE A  94
LEU A  98
 FMT  A 302 (-3.3A)
FMT  A 302 ( 4.2A)
None
None
 1.36A 3tgvD-3c2bA:
undetectable		 3tgvD-3c2bA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 3c2b TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Agrobacterium
fabrum) 		5 / 12 LEU A 110
ASN A 111
LEU A 113
GLN A 117
ARG A  57
 None
 1.26A 3zqtA-3c2bA:
undetectable		 3zqtA-3c2bA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 3c2b TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Agrobacterium
fabrum) 		3 / 3 ASP A 185
LYS A 186
ASP A 187
 None
 0.59A 4a7tA-3c2bA:
undetectable		 4a7tA-3c2bA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3c2b TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Agrobacterium
fabrum) 		4 / 8 HIS A 175
ASN A 111
GLY A 104
VAL A 101
 None
 1.01A 5m8rC-3c2bA:
undetectable		 5m8rC-3c2bA:
18.02