SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c2g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		5 / 11 ASP A 729
PHE A 685
VAL A 701
ILE A 705
ILE A 755
 None
 1.34A 1fkfA-3c2gA:
undetectable		 1fkfA-3c2gA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKJ_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		5 / 11 ASP A 729
PHE A 685
VAL A 701
ILE A 705
ILE A 755
 None
 1.35A 1fkjA-3c2gA:
undetectable		 1fkjA-3c2gA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		4 / 6 VAL A 710
VAL A 661
ILE A 674
ARG A 645
 None
 1.05A 1iepA-3c2gA:
undetectable		 1iepA-3c2gA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		4 / 7 VAL A 531
LEU A 501
THR A 499
VAL A 490
 None
 0.94A 1jgsA-3c2gA:
undetectable		 1jgsA-3c2gA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		5 / 12 THR A 653
LEU A 588
LEU A 551
LEU A 584
PHE A 655
 None
 1.21A 1mx1C-3c2gA:
undetectable		 1mx1C-3c2gA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		5 / 5 ILE A 618
LEU A 619
VAL A 661
ALA A 717
CYH A 715
 None
 1.10A 1mz9C-3c2gA:
undetectable		 1mz9C-3c2gA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		4 / 6 ILE A 784
VAL A 721
ILE A 728
ILE A 674
 None
 0.82A 1uwhB-3c2gA:
undetectable		 1uwhB-3c2gA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		5 / 12 LEU A 673
ILE A 674
VAL A 721
CYH A 678
LEU A 644
 None
 1.21A 1wsvB-3c2gA:
undetectable		 1wsvB-3c2gA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		5 / 11 VAL A 460
ILE A 468
GLY A 466
LEU A 496
PHE A 527
 None
 0.99A 1z11A-3c2gA:
undetectable		 1z11A-3c2gA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		5 / 11 VAL A 460
ILE A 468
GLY A 466
LEU A 496
PHE A 527
 None
 1.01A 1z11B-3c2gA:
undetectable		 1z11B-3c2gA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		5 / 10 VAL A 460
ILE A 468
GLY A 466
LEU A 496
PHE A 527
 None
 1.05A 1z11C-3c2gA:
undetectable		 1z11C-3c2gA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		5 / 10 VAL A 460
ILE A 468
GLY A 466
LEU A 496
PHE A 527
 None
 0.94A 1z11D-3c2gA:
undetectable		 1z11D-3c2gA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FKE_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		5 / 11 ASP A 729
PHE A 685
VAL A 701
ILE A 705
ILE A 755
 None
 1.36A 2fkeA-3c2gA:
undetectable		 2fkeA-3c2gA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		4 / 6 GLN A 609
ASN A 605
ASN A 585
LEU A 650
 None
 1.05A 2nyrA-3c2gA:
undetectable		 2nyrA-3c2gA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		4 / 7 THR A 633
PRO A 634
GLY A 635
LEU A 564
 None
 0.95A 2vl2B-3c2gA:
undetectable		 2vl2B-3c2gA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		3 / 3 MET A 623
VAL A 573
GLU A 563
 None
 0.75A 2x9gA-3c2gA:
undetectable		 2x9gA-3c2gA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		4 / 6 SER A 251
ALA A 254
HIS A 311
ASP A 309
 None
 1.30A 3aruA-3c2gA:
undetectable		 3aruA-3c2gA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		5 / 12 ILE A 388
LEU A 486
ILE A 456
SER A 453
ILE A 404
 None
 1.00A 3cd2A-3c2gA:
undetectable		 3cd2A-3c2gA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		5 / 12 LEU A 626
GLY A 635
LEU A 636
LEU A 644
CYH A 578
 None
 1.13A 3e23A-3c2gA:
undetectable		 3e23A-3c2gA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		4 / 6 VAL A 538
LEU A 588
ILE A 504
ILE A 541
 None
 0.88A 3gcsA-3c2gA:
undetectable		 3gcsA-3c2gA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		4 / 7 VAL A 710
VAL A 661
ILE A 674
ARG A 645
 None
 1.06A 3mssB-3c2gA:
undetectable		 3mssB-3c2gA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		3 / 3 PHE A 267
GLN A 318
PHE A 218
 None
 0.83A 3rv5A-3c2gA:
undetectable		 3rv5A-3c2gA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		5 / 11 VAL A 460
ILE A 468
GLY A 466
LEU A 496
PHE A 527
 None
 1.00A 3t3rA-3c2gA:
undetectable		 3t3rA-3c2gA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		4 / 5 PHE A 294
LEU A 261
THR A 268
VAL A 280
 None
 1.02A 3wrkD-3c2gA:
undetectable		 3wrkD-3c2gA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		4 / 7 THR A 653
ASN A 585
LEU A 584
PHE A 655
 None
 1.38A 4awuA-3c2gA:
undetectable		 4awuA-3c2gA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		5 / 11 PHE A 527
PHE A 459
GLN A 489
ALA A 493
LEU A 501
 None
 1.15A 4jbtB-3c2gA:
undetectable		 4jbtB-3c2gA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		3 / 3 ARG A 762
TRP A 766
ILE A 755
 None
 1.00A 4mwxA-3c2gA:
undetectable		 4mwxA-3c2gA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		4 / 8 PRO A 731
VAL A 721
TRP A 766
LEU A 756
 None
 1.00A 4pwdA-3c2gA:
undetectable		 4pwdA-3c2gA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		4 / 8 PHE A 795
ALA A 788
LEU A 791
PHE A 685
 None
 1.06A 4rkuA-3c2gA:
2.5
4rkuJ-3c2gA:
undetectable		 4rkuA-3c2gA:
21.35
4rkuJ-3c2gA:
5.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		4 / 8 GLY A 603
TRP A 591
GLU A 606
ASP A 540
 None
 1.06A 5gqbA-3c2gA:
undetectable		 5gqbA-3c2gA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		3 / 3 ILE A 371
ILE A 376
MET A 328
 None
 0.67A 5i9yA-3c2gA:
undetectable		 5i9yA-3c2gA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		4 / 8 ILE A 326
LEU A 234
ILE A 237
LEU A 335
 None
 0.99A 5ieoA-3c2gA:
undetectable		 5ieoA-3c2gA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		4 / 6 ILE A 277
ILE A 372
LEU A 343
HIS A 342
 None
 0.87A 5vkqA-3c2gA:
3.2
5vkqB-3c2gA:
3.2		 5vkqA-3c2gA:
16.34
5vkqB-3c2gA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		4 / 6 ILE A 277
ILE A 372
LEU A 343
HIS A 342
 None
 0.88A 5vkqB-3c2gA:
3.2
5vkqC-3c2gA:
3.2		 5vkqB-3c2gA:
16.34
5vkqC-3c2gA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		4 / 6 ILE A 277
ILE A 372
LEU A 343
HIS A 342
 None
 0.85A 5vkqC-3c2gA:
3.2
5vkqD-3c2gA:
3.2		 5vkqC-3c2gA:
16.34
5vkqD-3c2gA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		4 / 6 ILE A 277
ILE A 372
LEU A 343
HIS A 342
 None
 0.85A 5vkqA-3c2gA:
3.2
5vkqD-3c2gA:
3.2		 5vkqA-3c2gA:
16.34
5vkqD-3c2gA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		4 / 5 ASN A 733
TYR A 681
VAL A 684
LEU A 700
 None
 1.25A 6a7pA-3c2gA:
3.2		 6a7pA-3c2gA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		3 / 3 LEU A 501
THR A 583
ASN A 586
 None
 0.54A 6baaE-3c2gA:
2.4		 6baaE-3c2gA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		3 / 3 LEU A 501
THR A 583
ASN A 586
 None
 0.54A 6baaF-3c2gA:
2.4		 6baaF-3c2gA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		3 / 3 LEU A 501
THR A 583
ASN A 586
 None
 0.54A 6baaG-3c2gA:
2.4		 6baaG-3c2gA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		3 / 3 LEU A 501
THR A 583
ASN A 586
 None
 0.55A 6baaH-3c2gA:
2.4		 6baaH-3c2gA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 3c2g SYS-1 PROTEIN
(Caenorhabditis
elegans) 		4 / 8 PHE A 294
LEU A 261
THR A 268
VAL A 280
 None
 0.98A 6cp4A-3c2gA:
undetectable		 6cp4A-3c2gA:
22.06