SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c2o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_1
(HIV-1 PROTEASE)		 3c2o NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 141
ALA A 140
GLY A 258
GLY A 257
ILE A 274
 None
 0.85A 1hxbA-3c2oA:
undetectable		 1hxbA-3c2oA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 3c2o NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 119
MET A 157
SER A 123
ILE A 280
 None
 0.97A 3sfeB-3c2oA:
undetectable
3sfeC-3c2oA:
undetectable		 3sfeB-3c2oA:
22.19
3sfeC-3c2oA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3c2o NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Saccharomyces
cerevisiae) 		4 / 6 THR A 164
GLY A 141
ARG A 131
ILE A 280
 None
 0.92A 4acbC-3c2oA:
undetectable		 4acbC-3c2oA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3c2o NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 254
MET A 174
ASP A 227
GLY A 257
SER A 276
 NTM  A 300 ( 4.5A)
NTM  A 300 (-3.6A)
None
None
NTM  A 300 (-3.7A)
 1.33A 4djeB-3c2oA:
2.7		 4djeB-3c2oA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA301_0
(GLUTATHIONE
TRANSFERASE GTE1)		 3c2o NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 167
TRP A  21
PHE A  58
ARG A 151
 None
 1.45A 4g19A-3c2oA:
0.0		 4g19A-3c2oA:
22.12