SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c2q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3c2q UNCHARACTERIZED
CONSERVED PROTEIN
(Methanococcus
maripaludis) 		5 / 12 ILE A 217
LEU A 401
ALA A 239
ILE A 237
ILE A 234
 None
 1.02A 1epbA-3c2qA:
undetectable		 1epbA-3c2qA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 3c2q UNCHARACTERIZED
CONSERVED PROTEIN
(Methanococcus
maripaludis) 		3 / 3 THR A 378
PRO A 376
THR A 380
 None
 0.72A 209dC-3c2qA:
undetectable		 209dC-3c2qA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 3c2q UNCHARACTERIZED
CONSERVED PROTEIN
(Methanococcus
maripaludis) 		4 / 9 ILE A 309
ALA A 226
VAL A 229
GLU A 230
 None
 0.66A 2vufA-3c2qA:
undetectable		 2vufA-3c2qA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3c2q UNCHARACTERIZED
CONSERVED PROTEIN
(Methanococcus
maripaludis) 		5 / 12 GLY A 212
SER A 351
THR A 352
ILE A 237
LEU A 243
 None
IMD  A 501 (-4.0A)
None
None
None
 1.27A 3iv6D-3c2qA:
undetectable		 3iv6D-3c2qA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3c2q UNCHARACTERIZED
CONSERVED PROTEIN
(Methanococcus
maripaludis) 		4 / 7 TYR A 276
VAL A 326
ILE A 281
ARG A 318
 None
 1.08A 3ms9B-3c2qA:
undetectable		 3ms9B-3c2qA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_1
(PROTEASE)		 3c2q UNCHARACTERIZED
CONSERVED PROTEIN
(Methanococcus
maripaludis) 		6 / 12 ASP A 247
GLY A 299
VAL A 295
ILE A 305
ILE A 323
ILE A 248
 None
 1.34A 3s54A-3c2qA:
undetectable		 3s54A-3c2qA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 3c2q UNCHARACTERIZED
CONSERVED PROTEIN
(Methanococcus
maripaludis) 		5 / 12 ILE A 124
GLY A 153
ALA A  81
THR A 104
GLY A 150
 None
 1.00A 3uq6B-3c2qA:
4.7		 3uq6B-3c2qA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 3c2q UNCHARACTERIZED
CONSERVED PROTEIN
(Methanococcus
maripaludis) 		5 / 12 ILE A 124
GLY A 153
ALA A  81
THR A 104
GLY A 150
 None
 1.03A 3vaqB-3c2qA:
5.1		 3vaqB-3c2qA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3c2q UNCHARACTERIZED
CONSERVED PROTEIN
(Methanococcus
maripaludis) 		5 / 12 GLY A 222
SER A 250
LEU A 350
GLY A 213
ASP A 247
 None
 1.19A 4blvB-3c2qA:
undetectable		 4blvB-3c2qA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3c2q UNCHARACTERIZED
CONSERVED PROTEIN
(Methanococcus
maripaludis) 		4 / 7 GLU A 198
TYR A 200
GLY A 232
ARG A 197
 None
 0.84A 4fgzA-3c2qA:
undetectable		 4fgzA-3c2qA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 3c2q UNCHARACTERIZED
CONSERVED PROTEIN
(Methanococcus
maripaludis) 		5 / 11 ALA A 244
GLY A 321
VAL A 326
SER A 316
GLY A 240
 None
 1.11A 4xnxA-3c2qA:
1.8		 4xnxA-3c2qA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3c2q UNCHARACTERIZED
CONSERVED PROTEIN
(Methanococcus
maripaludis) 		3 / 3 ALA A 358
ASN A 361
LEU A 362
 None
 0.38A 5i1nB-3c2qA:
undetectable		 5i1nB-3c2qA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3c2q UNCHARACTERIZED
CONSERVED PROTEIN
(Methanococcus
maripaludis) 		3 / 3 ALA A 358
ASN A 361
LEU A 362
 None
 0.45A 5i1oA-3c2qA:
undetectable		 5i1oA-3c2qA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 3c2q UNCHARACTERIZED
CONSERVED PROTEIN
(Methanococcus
maripaludis) 		5 / 12 ALA A 184
LYS A 406
GLU A 409
LEU A 411
GLU A 412
 None
 1.23A 5nwuA-3c2qA:
undetectable		 5nwuA-3c2qA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3c2q UNCHARACTERIZED
CONSERVED PROTEIN
(Methanococcus
maripaludis) 		5 / 12 GLY A 240
ASP A 247
LEU A 401
ARG A 318
ILE A 217
 None
 1.18A 5vopB-3c2qA:
undetectable		 5vopB-3c2qA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 3c2q UNCHARACTERIZED
CONSERVED PROTEIN
(Methanococcus
maripaludis) 		5 / 9 SER A 256
ALA A 251
SER A 250
GLY A 254
ALA A 277
 None
 1.21A 6bklE-3c2qA:
undetectable
6bklF-3c2qA:
undetectable
6bklG-3c2qA:
undetectable
6bklH-3c2qA:
undetectable		 6bklE-3c2qA:
4.68
6bklF-3c2qA:
4.68
6bklG-3c2qA:
4.68
6bklH-3c2qA:
4.68