SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c2u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		4 / 7 LEU A 159
TYR A 139
HIS A 221
TYR A 224
 None
 1.37A 1afsA-3c2uA:
undetectable		 1afsA-3c2uA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		4 / 7 LEU A 159
TYR A 139
HIS A 221
TYR A 224
 None
 1.37A 1afsB-3c2uA:
undetectable		 1afsB-3c2uA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		4 / 6 GLU A  32
ARG A 290
ILE A  72
TRP A  73
 None
B3P  A 539 (-2.7A)
None
B3P  A 539 (-4.6A)
 1.48A 1nsiA-3c2uA:
undetectable
1nsiB-3c2uA:
undetectable		 1nsiA-3c2uA:
22.59
1nsiB-3c2uA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		4 / 8 ASP A 519
PHE A 400
SER A 404
ALA A 517
 None
 1.18A 1rqpA-3c2uA:
undetectable		 1rqpA-3c2uA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_2
(BETA-LACTAMASE
CTX-M-9)		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		4 / 5 CYH A 413
TYR A 501
PRO A 287
THR A 439
 None
 1.46A 1ymxA-3c2uA:
undetectable		 1ymxA-3c2uA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		4 / 5 CYH A 413
TYR A 501
PRO A 287
THR A 439
 None
 1.45A 1ymxB-3c2uA:
undetectable		 1ymxB-3c2uA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_A_LEUA1301_0
(LEUCYL-TRNA
SYNTHETASE)		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		4 / 7 TYR A 139
ASP A 133
TYR A 224
HIS A 221
 None
 1.31A 2bytA-3c2uA:
undetectable		 2bytA-3c2uA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_D_LEUD1601_0
(LEUCYL-TRNA
SYNTHETASE)		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		4 / 7 TYR A 139
ASP A 133
TYR A 224
HIS A 221
 None
 1.31A 2bytD-3c2uA:
undetectable		 2bytD-3c2uA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		5 / 9 GLY A 113
GLU A 109
ILE A 111
ALA A  52
VAL A  51
 None
 1.41A 2drdA-3c2uA:
undetectable		 2drdA-3c2uA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		5 / 12 ALA A 262
THR A 292
ILE A   3
LEU A 321
TYR A  24
 None
 1.19A 2nyrA-3c2uA:
undetectable		 2nyrA-3c2uA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		4 / 8 TYR A 139
ASP A 133
TYR A 224
HIS A 221
 None
 1.32A 2v0gA-3c2uA:
undetectable		 2v0gA-3c2uA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		4 / 8 ASP A 519
PHE A 400
SER A 404
ALA A 517
 None
 1.15A 2v7uA-3c2uA:
undetectable		 2v7uA-3c2uA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		5 / 11 ILE A 518
SER A 373
SER A 376
THR A 417
LYS A  64
 None
 1.14A 3bjwB-3c2uA:
undetectable		 3bjwB-3c2uA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		5 / 11 ILE A 518
SER A 373
SER A 376
THR A 417
LYS A  64
 None
 1.12A 3bjwE-3c2uA:
undetectable		 3bjwE-3c2uA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		5 / 12 ILE A 518
SER A 373
SER A 376
THR A 417
LYS A  64
 None
 1.09A 3bjwF-3c2uA:
undetectable		 3bjwF-3c2uA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		5 / 12 LEU A 497
THR A 417
THR A 412
ALA A 384
ALA A 511
 None
 0.93A 3mdvB-3c2uA:
undetectable		 3mdvB-3c2uA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		4 / 8 GLU A 291
TYR A 534
ARG A 267
PHE A 390
 None
 1.02A 3mjrD-3c2uA:
undetectable		 3mjrD-3c2uA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		5 / 10 ILE A 294
ALA A 262
ILE A 111
ILE A  87
ILE A  72
 None
 1.09A 3prsA-3c2uA:
undetectable		 3prsA-3c2uA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_A_WPPA300_2
(BETA-LACTAMASE)		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		4 / 5 CYH A 413
TYR A 501
PRO A 287
THR A 439
 None
 1.48A 3q07A-3c2uA:
undetectable		 3q07A-3c2uA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_B_WPPB400_2
(BETA-LACTAMASE)		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		4 / 5 CYH A 413
TYR A 501
PRO A 287
THR A 439
 None
 1.47A 3q07B-3c2uA:
undetectable		 3q07B-3c2uA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		3 / 3 HIS A 355
ARG A 371
GLU A 372
 None
 0.82A 3qf1A-3c2uA:
undetectable		 3qf1A-3c2uA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		3 / 3 GLN A 300
ASP A 229
GLN A 227
 None
 0.91A 4aztA-3c2uA:
undetectable		 4aztA-3c2uA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		4 / 7 GLU A  32
ARG A 290
ILE A  72
TRP A  73
 None
B3P  A 539 (-2.7A)
None
B3P  A 539 (-4.6A)
 1.48A 4cx7C-3c2uA:
undetectable
4cx7D-3c2uA:
undetectable		 4cx7C-3c2uA:
22.59
4cx7D-3c2uA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		4 / 7 GLU A  32
ARG A 290
ILE A  72
TRP A  73
 None
B3P  A 539 (-2.7A)
None
B3P  A 539 (-4.6A)
 1.48A 4nosA-3c2uA:
undetectable
4nosB-3c2uA:
undetectable		 4nosA-3c2uA:
20.97
4nosB-3c2uA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		4 / 7 ARG A 290
ILE A  72
TRP A  73
GLU A  32
 B3P  A 539 (-2.7A)
None
B3P  A 539 (-4.6A)
None
 1.46A 4nosC-3c2uA:
undetectable
4nosD-3c2uA:
undetectable		 4nosC-3c2uA:
20.97
4nosD-3c2uA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		5 / 12 LEU A 190
VAL A 141
PRO A 188
THR A 201
GLY A 204
 None
 1.24A 4q15A-3c2uA:
undetectable		 4q15A-3c2uA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		5 / 12 LEU A 190
VAL A 141
PRO A 188
THR A 201
GLY A 204
 None
 1.28A 4q15B-3c2uA:
undetectable		 4q15B-3c2uA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		5 / 12 ALA A 394
TYR A 534
ILE A  72
PHE A 512
LEU A  50
 None
 1.21A 5fsaA-3c2uA:
undetectable		 5fsaA-3c2uA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_1
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		4 / 4 ASP A  14
HIS A 189
SER A 250
GLU A 212
 B3P  A 539 (-2.7A)
None
None
None
 1.23A 5hfjC-3c2uA:
0.0		 5hfjC-3c2uA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		4 / 5 ILE A 454
LYS A 466
HIS A 464
VAL A 463
 None
 0.99A 5jmnA-3c2uA:
undetectable		 5jmnA-3c2uA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_1
(MINERALOCORTICOID
RECEPTOR)		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		4 / 6 GLN A 346
ARG A 386
THR A 106
PHE A  60
 None
 1.29A 5mwyA-3c2uA:
undetectable		 5mwyA-3c2uA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		5 / 12 LEU A 190
VAL A 141
PRO A 188
THR A 201
GLY A 204
 None
 1.25A 5xipC-3c2uA:
undetectable		 5xipC-3c2uA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		5 / 9 TYR A  24
ASP A  44
ALA A 262
ILE A 294
SER A  42
 None
 1.28A 6awoA-3c2uA:
undetectable		 6awoA-3c2uA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		5 / 9 TYR A  24
ASP A  44
ALA A 262
ILE A 294
SER A  42
 None
 1.28A 6awqA-3c2uA:
undetectable		 6awqA-3c2uA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		3 / 3 ILE A  26
ASN A   5
CYH A 246
 None
 0.84A 6bp4A-3c2uA:
undetectable		 6bp4A-3c2uA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		4 / 8 ASN A 516
HIS A 424
VAL A 438
SER A 421
 None
 1.21A 6huoC-3c2uA:
undetectable
6huoD-3c2uA:
undetectable		 6huoC-3c2uA:
11.06
6huoD-3c2uA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3c2u XYLOSIDASE/ARABINOSI
DASE
(Selenomonas
ruminantium) 		4 / 7 HIS A 382
GLU A  32
ASP A  68
GLU A 418
 None
 1.31A 6mn4F-3c2uA:
undetectable		 6mn4F-3c2uA:
17.39