SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c3j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 3c3j PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE
(Escherichia
coli) 		5 / 12 LEU A 184
ILE A 138
PHE A 110
ILE A  71
TRP A  74
 None
 1.15A 1ot7B-3c3jA:
undetectable		 1ot7B-3c3jA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3c3j PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE
(Escherichia
coli) 		5 / 12 PHE A 281
PHE A 219
PHE A 214
LEU A 211
VAL A 218
 None
 1.40A 1q23C-3c3jA:
undetectable		 1q23C-3c3jA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 3c3j PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE
(Escherichia
coli) 		5 / 12 SER A 283
TYR A 291
GLY A 234
LEU A 235
PRO A 261
 None
 1.26A 1vpoH-3c3jA:
undetectable
1vpoL-3c3jA:
undetectable		 1vpoH-3c3jA:
20.10
1vpoL-3c3jA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3c3j PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE
(Escherichia
coli) 		3 / 3 ILE A 176
ILE A  70
LEU A 146
 None
 0.52A 2prgA-3c3jA:
undetectable		 2prgA-3c3jA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 3c3j PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE
(Escherichia
coli) 		4 / 6 SER A  30
PHE A 197
ILE A 192
PHE A 340
 None
 1.19A 2qeiA-3c3jA:
undetectable		 2qeiA-3c3jA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 3c3j PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE
(Escherichia
coli) 		4 / 5 SER A 116
LEU A  91
GLY A  60
GLU A 118
 None
 1.02A 3aiaA-3c3jA:
undetectable
3aiaB-3c3jA:
undetectable		 3aiaA-3c3jA:
20.10
3aiaB-3c3jA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 3c3j PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE
(Escherichia
coli) 		4 / 8 ILE A  20
GLN A 347
ALA A 350
LEU A 351
 None
 0.70A 3ozwA-3c3jA:
5.2		 3ozwA-3c3jA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 3c3j PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE
(Escherichia
coli) 		5 / 11 LEU A 235
ALA A 310
ILE A 309
THR A 288
PRO A 261
 None
 1.50A 3qelA-3c3jA:
2.7
3qelB-3c3jA:
3.6		 3qelA-3c3jA:
21.48
3qelB-3c3jA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 3c3j PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE
(Escherichia
coli) 		5 / 12 GLY A 234
GLY A 231
TYR A 258
LEU A 244
ALA A  65
 None
 1.13A 3t7vA-3c3jA:
undetectable		 3t7vA-3c3jA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3c3j PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE
(Escherichia
coli) 		5 / 12 LEU A 106
ILE A  67
LEU A 159
PHE A  44
ILE A  34
 None
 1.38A 3w67D-3c3jA:
1.4		 3w67D-3c3jA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 3c3j PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE
(Escherichia
coli) 		4 / 7 ALA A 346
PHE A 281
ALA A 238
ALA A 243
 None
 0.74A 4du2A-3c3jA:
undetectable		 4du2A-3c3jA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3c3j PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE
(Escherichia
coli) 		5 / 12 LEU A 296
ASP A 292
SER A 232
VAL A 319
ALA A 239
 None
 1.25A 4nc3A-3c3jA:
undetectable		 4nc3A-3c3jA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3c3j PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE
(Escherichia
coli) 		3 / 3 ASN A 155
LEU A  54
PHE A 157
 None
 0.75A 5dsgA-3c3jA:
1.2		 5dsgA-3c3jA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODH_G_ACTG710_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 3c3j PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE
(Escherichia
coli) 		4 / 4 ARG A 203
ILE A 207
TYR A 345
ILE A 311
 None
 1.40A 5odhG-3c3jA:
3.0		 5odhG-3c3jA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 3c3j PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE
(Escherichia
coli) 		5 / 12 ALA A  10
PHE A 281
ALA A 239
ALA A 243
MET A 352
 None
 1.24A 5tl8A-3c3jA:
2.3		 5tl8A-3c3jA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3c3j PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE
(Escherichia
coli) 		4 / 4 VAL A  86
LEU A 105
ASN A  94
ASP A  97
 None
 1.32A 5vcyA-3c3jA:
undetectable		 5vcyA-3c3jA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3c3j PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE
(Escherichia
coli) 		4 / 4 VAL A  86
LEU A 107
ASN A  94
ASP A  97
 None
 1.17A 5vcyA-3c3jA:
undetectable		 5vcyA-3c3jA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 3c3j PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE
(Escherichia
coli) 		4 / 8 GLY A  60
ARG A 240
ASP A  69
ASP A  90
 None
 0.97A 5vlmB-3c3jA:
undetectable		 5vlmB-3c3jA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 3c3j PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE
(Escherichia
coli) 		5 / 12 ALA A 222
ALA A   8
ALA A  10
THR A  12
LEU A 351
 None
 1.35A 6aycA-3c3jA:
undetectable		 6aycA-3c3jA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 3c3j PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE
(Escherichia
coli) 		4 / 7 ALA A 243
LYS A 245
GLU A 248
LEU A 254
 None
 1.10A 6ci6A-3c3jA:
undetectable		 6ci6A-3c3jA:
11.35