SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3c3k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FB7_A_ROCA100_1
(HIV-1 PROTEASE)		 3c3k ALANINE RACEMASE
(Actinobacillus
succinogenes) 		5 / 12 GLY A 198
ALA A 197
VAL A 217
GLY A 218
ILE A 224
 None
 0.98A 1fb7A-3c3kA:
undetectable		 1fb7A-3c3kA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 3c3k ALANINE RACEMASE
(Actinobacillus
succinogenes) 		5 / 12 VAL A 115
ASN A 131
ILE A 130
LEU A 129
LEU A 119
 None
 1.06A 1r9oA-3c3kA:
undetectable		 1r9oA-3c3kA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 3c3k ALANINE RACEMASE
(Actinobacillus
succinogenes) 		5 / 11 VAL A 115
VAL A 217
GLU A 113
LEU A 150
ILE A 127
 None
 1.42A 1t6zA-3c3kA:
3.7		 1t6zA-3c3kA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 3c3k ALANINE RACEMASE
(Actinobacillus
succinogenes) 		5 / 11 VAL A 115
VAL A 217
GLU A 113
LEU A 150
ILE A 127
 None
 1.37A 1t6zB-3c3kA:
undetectable		 1t6zB-3c3kA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 3c3k ALANINE RACEMASE
(Actinobacillus
succinogenes) 		5 / 12 ILE A 130
LYS A 172
ILE A 210
LEU A 203
ILE A 188
 None
 1.03A 2drcB-3c3kA:
2.2		 2drcB-3c3kA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3c3k ALANINE RACEMASE
(Actinobacillus
succinogenes) 		3 / 3 ILE A 188
ILE A 210
LEU A 155
 None
 0.54A 2prgA-3c3kA:
undetectable		 2prgA-3c3kA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3c3k ALANINE RACEMASE
(Actinobacillus
succinogenes) 		5 / 12 ILE A 130
LYS A 172
ILE A 210
LEU A 203
ILE A 188
 None
 1.05A 3drcB-3c3kA:
2.7		 3drcB-3c3kA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 3c3k ALANINE RACEMASE
(Actinobacillus
succinogenes) 		5 / 12 LEU A 208
VAL A 216
LEU A 232
ILE A 130
LEU A 179
 None
 1.16A 3ijdB-3c3kA:
undetectable		 3ijdB-3c3kA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 3c3k ALANINE RACEMASE
(Actinobacillus
succinogenes) 		5 / 12 ILE A 130
LEU A 232
LYS A 172
ILE A 210
ILE A 188
 None
 0.94A 3tq9A-3c3kA:
2.8		 3tq9A-3c3kA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 3c3k ALANINE RACEMASE
(Actinobacillus
succinogenes) 		6 / 12 ILE A 130
LYS A 172
SER A 276
ILE A 210
LEU A 203
ILE A 188
 None
 1.17A 3tq9A-3c3kA:
2.8		 3tq9A-3c3kA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3c3k ALANINE RACEMASE
(Actinobacillus
succinogenes) 		5 / 12 ILE A 130
LYS A 172
ILE A 210
LEU A 203
ILE A 188
 None
 0.99A 4i13A-3c3kA:
2.5		 4i13A-3c3kA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3c3k ALANINE RACEMASE
(Actinobacillus
succinogenes) 		5 / 12 ILE A 130
LYS A 172
ILE A 210
LEU A 203
ILE A 188
 None
 1.00A 4kjjA-3c3kA:
2.2		 4kjjA-3c3kA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3c3k ALANINE RACEMASE
(Actinobacillus
succinogenes) 		4 / 7 VAL A  27
ILE A  30
LEU A  59
LEU A  12
 None
 1.05A 4l1wA-3c3kA:
undetectable		 4l1wA-3c3kA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3c3k ALANINE RACEMASE
(Actinobacillus
succinogenes) 		5 / 11 ILE A 130
LYS A 172
SER A 276
ILE A 210
ILE A 188
 None
 1.02A 4p68A-3c3kA:
2.8		 4p68A-3c3kA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3c3k ALANINE RACEMASE
(Actinobacillus
succinogenes) 		5 / 12 VAL A 247
GLY A  67
ASP A  66
GLY A  38
LYS A   7
 None
 1.38A 4pevB-3c3kA:
19.4		 4pevB-3c3kA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3c3k ALANINE RACEMASE
(Actinobacillus
succinogenes) 		5 / 12 ILE A 130
LYS A 172
ILE A 210
LEU A 203
ILE A 188
 None
 1.06A 4pthA-3c3kA:
2.6		 4pthA-3c3kA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 3c3k ALANINE RACEMASE
(Actinobacillus
succinogenes) 		4 / 7 ALA A 190
ALA A 197
THR A 228
SER A 276
 None
 0.82A 4r1zB-3c3kA:
undetectable		 4r1zB-3c3kA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3c3k ALANINE RACEMASE
(Actinobacillus
succinogenes) 		4 / 7 VAL A  27
ILE A  30
LEU A  59
LEU A  12
 None
 1.01A 4xo7A-3c3kA:
undetectable		 4xo7A-3c3kA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 3c3k ALANINE RACEMASE
(Actinobacillus
succinogenes) 		3 / 3 VAL A 272
THR A 234
ARG A 274
 None
 0.72A 5b2sB-3c3kA:
undetectable		 5b2sB-3c3kA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 3c3k ALANINE RACEMASE
(Actinobacillus
succinogenes) 		3 / 3 VAL A 272
THR A 234
ARG A 274
 None
 0.75A 5b2tB-3c3kA:
undetectable		 5b2tB-3c3kA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3c3k ALANINE RACEMASE
(Actinobacillus
succinogenes) 		5 / 10 ILE A  30
ILE A  69
VAL A  26
GLU A  94
ASP A  72
 None
 1.13A 5lg3F-3c3kA:
undetectable		 5lg3F-3c3kA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3c3k ALANINE RACEMASE
(Actinobacillus
succinogenes) 		5 / 12 VAL A 104
SER A 239
ILE A  18
ALA A  24
VAL A  15
 None
 1.18A 5n0sB-3c3kA:
3.4		 5n0sB-3c3kA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 3c3k ALANINE RACEMASE
(Actinobacillus
succinogenes) 		4 / 8 VAL A 101
GLY A  67
GLN A 253
LEU A 250
 None
 1.00A 5sxqA-3c3kA:
undetectable		 5sxqA-3c3kA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 3c3k ALANINE RACEMASE
(Actinobacillus
succinogenes) 		4 / 8 VAL A 101
GLY A  67
GLN A 253
LEU A 250
 None
 0.97A 5sxtA-3c3kA:
undetectable		 5sxtA-3c3kA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 3c3k ALANINE RACEMASE
(Actinobacillus
succinogenes) 		4 / 8 VAL A 101
GLY A  67
GLN A 253
LEU A 250
 None
 0.96A 5sxtB-3c3kA:
undetectable		 5sxtB-3c3kA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 3c3k ALANINE RACEMASE
(Actinobacillus
succinogenes) 		4 / 8 VAL A 101
GLY A  67
GLN A 253
LEU A 250
 None
 0.93A 5syjB-3c3kA:
undetectable		 5syjB-3c3kA:
17.31